Cd40lg^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Cd40lg^tm1Flv
• Name: CD40 ligand; targeted mutation 1, Richard A Flavell
• MGI ID: MGI:2182733
• Synonyms: CD154^-, CD154KO, CD40L-, CD40L def., Cd40lg-
• Gene: Cd40lg Location: ChrX:56257503-56269402 bp, + strand Genetic Position: ChrX, 31.21 cM
• Alliance: Cd40lg^tm1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:25010
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 500 base pair BamHI-XbaI fragment, corresponding to bases 368 through 417 of the cDNA, was replaced with a neomycin selection cassette. The encoded protein was undetected via flow cytometry on the surface of activated T cells derived from homozygous mutant mice. (J:25010)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd40lg Mutation: 14 strains or lines available

References

• Original: J:25010 Xu J, et al., Mice deficient for the CD40 ligand [published erratum appears in Immunity 1994 Oct;1(7):following 613]. Immunity. 1994 Aug;1(5):423-31
• All: 54 reference(s)