All Phenotypes Egfr<Wa5> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Egfr^Wa5
waved 5
MGI:2178387

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Egfr^Wa5/Egfr^Wa5	involves: BALB/cAnN * C3H/HeN	MGI:2686885
hm2	Egfr^Wa5/Egfr^Wa5	involves: BALB/cAnN * C3H/HeN * C57BL/6J	MGI:3623308
ht3	Egfr^Wa5/Egfr⁺	involves: BALB/cAnN * C3H/HeN	MGI:2686884
ht4	Egfr^Wa5/Egfr⁺	involves: BALB/cAnN * C3H/HeN * C57BL/6J	MGI:3623311
ht5	Egfr^wa2/Egfr^Wa5	involves: BALB/cAnN * C3H/HeN * C57BL/6J	MGI:3623313
cx6	Egfr^Wa5/Egfr⁺ Tgfa^tm1Unc/Tgfa^tm1Unc	involves: 129P2/OlaHsd * BALB/cAnN * C3H/HeN * C57BL/6J	MGI:3623314
cx7	Apc^Min/Apc⁺ Egfr^Wa5/Egfr⁺	involves: BALB/cAnN * C3H/HeN * C57BL/6J	MGI:3623317

Allelic Composition	Egfr^Wa5/Egfr^Wa5
Genetic Background	involves: BALB/cAnN * C3H/HeN

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^Wa5 mutation (2 available); any Egfr mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:75964 )

• in intercross litters of heterozygous mice, no homozygous mice are found

Allelic Composition	Egfr^Wa5/Egfr^Wa5
Genetic Background	involves: BALB/cAnN * C3H/HeN * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^Wa5 mutation (2 available); any Egfr mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Histological placentae analysis of the Egfr^Wa5/Egfr^Wa5 and Egfr^Wa5/⁺ mice

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:92308 )

• embryos surviving past E12.5 die by birth or very shortly after

embryonic lethality during organogenesis, incomplete penetrance ( J:92308 )

• morphologically normal at E10.5

• 71% lethality between E10.5 and E12.5

embryo

abnormal placenta morphology ( J:92308 )

• defective placentas with phenotypes ranging from mild defects to severely affected

decreased spongiotrophoblast size ( J:92308 )

• reduced spongiotrophoblast at E12.5

• spongiotrophoblast reduction very significant in runted embryos

abnormal placenta labyrinth morphology ( J:92308 )

• variably compromised labyrinthine layer

• multinucleated labyrinthine trophoblasts

• reduced thickness

• multiple blood pockets found in runted embryos

Allelic Composition	Egfr^Wa5/Egfr⁺
Genetic Background	involves: BALB/cAnN * C3H/HeN

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^Wa5 mutation (2 available); any Egfr mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye morphology ( J:75964 )

cornea scarring ( J:75964 )

• damage from the open eyelids in the form of corneal scarring is dependent on environment, where mice raised in a pathogen free environment have no apparent defects in eye development

eyelids open at birth ( J:75964 )

• apart from the open eyelids, the eyes of neonates appear normal

integument

abnormal hair texture ( J:75964 )

waved hair ( J:75964 )

• the first coat is described as wavy and subsequent coats are scruffy in appearance

abnormal vibrissa morphology ( J:75964 )

curly vibrissae ( J:75964 )

Allelic Composition	Egfr^Wa5/Egfr⁺
Genetic Background	involves: BALB/cAnN * C3H/HeN * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^Wa5 mutation (2 available); any Egfr mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Histological placentae analysis of the Egfr^Wa5/Egfr^Wa5 and Egfr^Wa5/⁺ mice

embryo

abnormal placenta morphology ( J:92308 )

• mildly abnormal placentas

decreased spongiotrophoblast size ( J:92308 )

• reduced spongiotrophoblast at E12.5

abnormal placenta labyrinth morphology ( J:92308 )

• variably compromised labyrinthine layer

• multinucleated labyrinthine trophoblasts

Allelic Composition	Egfr^wa2/Egfr^Wa5
Genetic Background	involves: BALB/cAnN * C3H/HeN * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^wa2 mutation (2 available); any Egfr mutation (88 available)
Egfr^Wa5 mutation (2 available); any Egfr mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Phenotypes of Egfr^wa2/Egfr^Wa5 and Tgfa^tm1Unc/Tgfa^tm1Unc Egfr^Wa5/⁺ mice

mortality/aging

perinatal lethality, incomplete penetrance ( J:92308 )

• born at about half the expected rate

postnatal lethality, incomplete penetrance ( J:92308 )

• heavy death rate over the first 3 weeks of life

growth/size/body

mandible hypoplasia ( J:92308 )

• underdeveloped lower jaw

asymmetric snout ( J:92308 )

• narrow, asymmetric snout

long snout ( J:92308 )

• elongated snout

narrow snout ( J:92308 )

• narrow, asymmetric snout

decreased body weight ( J:92308 )

• body weight ranges from 30-50% of controls in mutants that survive for 3 months after birth

postnatal growth retardation ( J:92308 )

• 25% reduction in body size in mice surviving to 6 weeks of age

craniofacial

mandible hypoplasia ( J:92308 )

• underdeveloped lower jaw

asymmetric snout ( J:92308 )

• narrow, asymmetric snout

long snout ( J:92308 )

• elongated snout

narrow snout ( J:92308 )

• narrow, asymmetric snout

reproductive system

delayed vaginal opening ( J:92308 )

• vaginal opening delayed until around 11 months of age

abnormal fertility/fecundity ( J:92308 )

• no offspring produced by either sex by 3 months of age

skeleton

mandible hypoplasia ( J:92308 )

• underdeveloped lower jaw

vision/eye

abnormal eye morphology ( J:92308 )

• eye defects

integument

alopecia ( J:92308 )

• complete hair loss occurs around 8 weeks of age with resumption of hair growth sometime thereafter

loss of vibrissae ( J:92308 )

Allelic Composition	Egfr^Wa5/Egfr⁺ Tgfa^tm1Unc/Tgfa^tm1Unc
Genetic Background	involves: 129P2/OlaHsd * BALB/cAnN * C3H/HeN * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^Wa5 mutation (2 available); any Egfr mutation (88 available)
Tgfa^tm1Unc mutation (3 available); any Tgfa mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Phenotypes of Egfr^wa2/Egfr^Wa5 and Tgfa^tm1Unc/Tgfa^tm1Unc Egfr^Wa5/⁺ mice

growth/size/body

small mandible ( J:92308 )

• smaller lower jaw

postnatal growth retardation ( J:92308 )

• reduced postnatal growth although size at birth is normal

• noticeably reduced in size by 1 week of age

• 25% reduction in body size in mice surviving to 6 weeks of age

craniofacial

small mandible ( J:92308 )

• smaller lower jaw

skeleton

small mandible ( J:92308 )

• smaller lower jaw

Allelic Composition	Apc^Min/Apc⁺ Egfr^Wa5/Egfr⁺
Genetic Background	involves: BALB/cAnN * C3H/HeN * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (151 available)
Egfr^Wa5 mutation (2 available); any Egfr mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor incidence ( J:92308 )

• 46% reduction in the number of macroscopic intestinal polyps in comparison to mice heterozygous only for Apc^Min at 3 months of age

• no reduction in tumor size

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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