Phenotypes associated with this allele
Allelic
Composition |
EgfrWa5/EgfrWa5
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Genetic
Background |
involves: BALB/cAnN * C3H/HeN |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
EgfrWa5 mutation
(2 available);
any
Egfr mutation
(85 available)
|
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mortality/aging
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• in intercross litters of heterozygous mice, no homozygous mice are found
|
Allelic
Composition |
EgfrWa5/EgfrWa5
|
|
Genetic
Background |
involves: BALB/cAnN * C3H/HeN * C57BL/6J |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
EgfrWa5 mutation
(2 available);
any
Egfr mutation
(85 available)
|
|
|
Histological placentae analysis of the EgfrWa5/EgfrWa5 and EgfrWa5/+ mice
mortality/aging
|
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• embryos surviving past E12.5 die by birth or very shortly after
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• morphologically normal at E10.5
• 71% lethality between E10.5 and E12.5
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embryo
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• defective placentas with phenotypes ranging from mild defects to severely affected
|
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• reduced spongiotrophoblast at E12.5
• spongiotrophoblast reduction very significant in runted embryos
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• variably compromised labyrinthine layer
• multinucleated labyrinthine trophoblasts
• reduced thickness
• multiple blood pockets found in runted embryos
|
Allelic
Composition |
EgfrWa5/Egfr+
|
|
Genetic
Background |
involves: BALB/cAnN * C3H/HeN |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
EgfrWa5 mutation
(2 available);
any
Egfr mutation
(85 available)
|
|
|
vision/eye
|
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• damage from the open eyelids in the form of corneal scarring is dependent on environment, where mice raised in a pathogen free environment have no apparent defects in eye development
|
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• apart from the open eyelids, the eyes of neonates appear normal
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integument
|
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• the first coat is described as wavy and subsequent coats are scruffy in appearance
|
Allelic
Composition |
EgfrWa5/Egfr+
|
|
Genetic
Background |
involves: BALB/cAnN * C3H/HeN * C57BL/6J |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
EgfrWa5 mutation
(2 available);
any
Egfr mutation
(85 available)
|
|
|
Histological placentae analysis of the EgfrWa5/EgfrWa5 and EgfrWa5/+ mice
embryo
|
|
• mildly abnormal placentas
|
|
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• reduced spongiotrophoblast at E12.5
|
|
|
• variably compromised labyrinthine layer
• multinucleated labyrinthine trophoblasts
|
Allelic
Composition |
Egfrwa2/EgfrWa5
|
|
Genetic
Background |
involves: BALB/cAnN * C3H/HeN * C57BL/6J |
|
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Phenotypes of Egfrwa2/EgfrWa5 and Tgfatm1Unc/Tgfatm1Unc EgfrWa5/+ mice
mortality/aging
|
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• born at about half the expected rate
|
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• heavy death rate over the first 3 weeks of life
|
growth/size/body
|
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• narrow, asymmetric snout
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• narrow, asymmetric snout
|
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• body weight ranges from 30-50% of controls in mutants that survive for 3 months after birth
|
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• 25% reduction in body size in mice surviving to 6 weeks of age
|
craniofacial
|
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• underdeveloped lower jaw
|
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• narrow, asymmetric snout
|
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• narrow, asymmetric snout
|
reproductive system
 |
• vaginal opening delayed until around 11 months of age
|
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• no offspring produced by either gender by 3 months of age
|
skeleton
|
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• underdeveloped lower jaw
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vision/eye
integument
|
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• complete hair loss occurs around 8 weeks of age with resumption of hair growth sometime thereafter
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Phenotypes of Egfrwa2/EgfrWa5 and Tgfatm1Unc/Tgfatm1Unc EgfrWa5/+ mice
growth/size/body
|
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• reduced postnatal growth although size at birth is normal
• noticeably reduced in size by 1 week of age
• 25% reduction in body size in mice surviving to 6 weeks of age
|
craniofacial
skeleton
Allelic
Composition |
ApcMin/Apc+
EgfrWa5/Egfr+
|
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Genetic
Background |
involves: BALB/cAnN * C3H/HeN * C57BL/6J |
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neoplasm
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• 46% reduction in the number of macroscopic intestinal polyps in comparison to mice heterozygous only for ApcMin at 3 months of age
• no reduction in tumor size
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Analysis Tools
