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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(KRT5-cre/ERT2)2Ipc
transgene insertion 2, I Pierre Chambon
MGI:2177429
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tg(KRT5-cre/ERT2)2Ipc/0
Upf3atm1.1Wilk/Upf3atm1.1Wilk 		involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL MGI:6117764
cn2
 		Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu
Tg(KRT5-cre/ERT2)2Ipc/0 		involves: 129/Sv * C57BL/6 * SJL MGI:4454659


Genotype
MGI:6117764
cn1
Allelic
Composition		 Tg(KRT5-cre/ERT2)2Ipc/0
Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic
Background		 involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT5-cre/ERT2)2Ipc mutation (3 available)
Upf3atm1.1Wilk mutation (0 available); any Upf3a mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:234504 )
• reduced expression of NMD (nonsense-mediated decay) target transcripts Atf4, Cdh11, Ern2, Smad5 and Smad7 in olfactory epithelium




Genotype
MGI:4454659
cn2
Allelic
Composition		 Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu
Tg(KRT5-cre/ERT2)2Ipc/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1tm1.1Dmsu mutation (1 available); any Foxn1 mutation (106 available)
Tg(KRT5-cre/ERT2)2Ipc mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Thymic atrophy in tamoxifen treated Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu Tg(KRT5-cre/ERT2)2Ipc/0 mice and Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu Tg(CAG-cre/Esr1*)5Amc/0 mice

immune system
abnormal thymus corticomedullary boundary morphology ( J:159773 )
• following tamoxifen treatment, the medullary region architecture is altered and the corticomedullary junction becomes indistinct compared to in wild-type mice
abnormal thymus medulla morphology ( J:159773 )
• following tamoxifen treatment, the medullary region architecture is altered and the corticomedullary junction becomes indistinct compared to in wild-type mice
small thymus ( J:159773 )
• following tamoxifen treatment
thymus atrophy ( J:159773 )
• following tamoxifen treatment
decreased thymocyte number ( J:159773 )
• following tamoxifen treatment

hematopoietic system
abnormal thymus corticomedullary boundary morphology ( J:159773 )
• following tamoxifen treatment, the medullary region architecture is altered and the corticomedullary junction becomes indistinct compared to in wild-type mice
abnormal thymus medulla morphology ( J:159773 )
• following tamoxifen treatment, the medullary region architecture is altered and the corticomedullary junction becomes indistinct compared to in wild-type mice
small thymus ( J:159773 )
• following tamoxifen treatment
thymus atrophy ( J:159773 )
• following tamoxifen treatment
decreased thymocyte number ( J:159773 )
• following tamoxifen treatment

endocrine/exocrine glands
abnormal thymus corticomedullary boundary morphology ( J:159773 )
• following tamoxifen treatment, the medullary region architecture is altered and the corticomedullary junction becomes indistinct compared to in wild-type mice
abnormal thymus medulla morphology ( J:159773 )
• following tamoxifen treatment, the medullary region architecture is altered and the corticomedullary junction becomes indistinct compared to in wild-type mice
small thymus ( J:159773 )
• following tamoxifen treatment
thymus atrophy ( J:159773 )
• following tamoxifen treatment
decreased thymocyte number ( J:159773 )
• following tamoxifen treatment




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory