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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Krt1-5-cre/ERT)1Ipc
transgene insertion 1, I Pierre Chambon
MGI:2177427
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Plectm2Gwi/Plectm4Gwi
Tg(Krt1-5-cre/ERT)1Ipc/? 		involves: 129 * C57BL/6 * SJL MGI:3723353
cn2
 		Juntm4Wag/Juntm4Wag
Junbtm3Wag/Junbtm3Wag
Tg(Krt1-5-cre/ERT)1Ipc/0 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5578332
cn3
 		Chuktm1Yhu/Chuktm1Yhu
Tg(Krt1-5-cre/ERT)1Ipc/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3817627
cn4
 		Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Tg(Krt1-5-cre/ERT)1Ipc/0 		involves: 129X1/SvJ * C57BL/6 * SJL MGI:4452397


Genotype
MGI:3723353
cn1
Allelic
Composition		 Plectm2Gwi/Plectm4Gwi
Tg(Krt1-5-cre/ERT)1Ipc/?
Genetic
Background		 involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plectm2Gwi mutation (0 available); any Plec mutation (175 available)
Plectm4Gwi mutation (0 available); any Plec mutation (175 available)
Tg(Krt1-5-cre/ERT)1Ipc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
impaired skin barrier function ( J:124213 )
• following treatment with tamoxifen and tape stripping (10 times), mice exhibit increased transepidermal water loss not observed in control Plec1tm4Gwi homozygotes

integument
impaired skin barrier function ( J:124213 )
• following treatment with tamoxifen and tape stripping (10 times), mice exhibit increased transepidermal water loss not observed in control Plec1tm4Gwi homozygotes
blistering ( J:124213 )
• following treatment with tamoxifen and tape stripping (10 times), mice develop small blisters
abnormal skin condition ( J:124213 )
• skin around lesions induced by treatment with tamoxifen and tape stripping (10 times) is more fragile




Genotype
MGI:5578332
cn2
Allelic
Composition		 Juntm4Wag/Juntm4Wag
Junbtm3Wag/Junbtm3Wag
Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Junbtm3Wag mutation (1 available); any Junb mutation (21 available)
Juntm4Wag mutation (0 available); any Jun mutation (14 available)
Tg(Krt1-5-cre/ERT)1Ipc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
skin inflammation ( J:116380 )
• intra-epidermal T cells, epidermal micro-abscesses and typical inflammatory-cell infiltrate consisting of neutrophils, and an increase in numbers of macrophages in the dermis are seen in mice 8-10 days after tamoxifen induction
abnormal skin morphology ( J:116380 )
• mice treated with tamoxifen show an increase in subepidermal vascularization
hyperkeratosis ( J:116380 )
• thickening of keratinized upper layers in mice treated with tamoxifen
parakeratosis ( J:116380 )
• in mice treated with tamoxifen
thick epidermis ( J:116380 )
• mice treated with tamoxifen show thickened epidermis with prominent rete ridge
psoriasis ( J:116380 )
• mice treated with tamoxifen at 8 weeks of age develop psoriasis-like skin lesions on hairless skin 8-10 days after tamoxifen induction, showing scaly plaques affecting primarily ears, paws and tail, and less frequently the hairy back skin

immune system
increased inflammatory response ( J:116380 )
• periostitis in mice treated with tamoxifen
autoimmune arthritis ( J:116380 )
• arthritic lesions similar to psoriatic arthritis are seen in 100% of mice treated with tamoxifen, showing inflammatory infiltrates in joint regions
skin inflammation ( J:116380 )
• intra-epidermal T cells, epidermal micro-abscesses and typical inflammatory-cell infiltrate consisting of neutrophils, and an increase in numbers of macrophages in the dermis are seen in mice 8-10 days after tamoxifen induction

skeleton
autoimmune arthritis ( J:116380 )
• arthritic lesions similar to psoriatic arthritis are seen in 100% of mice treated with tamoxifen, showing inflammatory infiltrates in joint regions
abnormal bone structure ( J:116380 )
• massive bone destruction
abnormal periosteum morphology ( J:116380 )
• periostitis in mice treated with tamoxifen

cardiovascular system
abnormal blood vessel morphology ( J:116380 )
• mice treated with tamoxifen show an increase in subepidermal vascularization

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
psoriasis DOID:8893 OMIM:PS177900
 J:116380




Genotype
MGI:3817627
cn3
Allelic
Composition		 Chuktm1Yhu/Chuktm1Yhu
Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuktm1Yhu mutation (0 available); any Chuk mutation (53 available)
Tg(Krt1-5-cre/ERT)1Ipc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased skin tumor incidence ( J:141162 )
• 10 to 12 months following induction with tamoxifen

integument
epidermal hyperplasia ( J:141162 )
• after tamoxifen induction, mice exhibit dorsal epidermis hyperplasia
increased skin tumor incidence ( J:141162 )
• 10 to 12 months following induction with tamoxifen




Genotype
MGI:4452397
cn4
Allelic
Composition		 Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Smo/EYFP)Amc mutation (1 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(Krt1-5-cre/ERT)1Ipc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased basal cell carcinoma incidence ( J:158915 )
• tamoxifen-treated mice develop basal cell carcinomas that are restricted to the epidermis

integument
increased basal cell carcinoma incidence ( J:158915 )
• tamoxifen-treated mice develop basal cell carcinomas that are restricted to the epidermis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory