All Phenotypes Tg(Krt1-5-cre/ERT)1Ipc MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Plec^tm2Gwi/Plec^tm4Gwi Tg(Krt1-5-cre/ERT)1Ipc/?	involves: 129 * C57BL/6 * SJL	MGI:3723353
cn2	Jun^tm4Wag/Jun^tm4Wag Junb^tm3Wag/Junb^tm3Wag Tg(Krt1-5-cre/ERT)1Ipc/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5578332
cn3	Chuk^tm1Yhu/Chuk^tm1Yhu Tg(Krt1-5-cre/ERT)1Ipc/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3817627
cn4	Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}/Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc} Tg(Krt1-5-cre/ERT)1Ipc/0	involves: 129X1/SvJ * C57BL/6 * SJL	MGI:4452397

Allelic Composition	Plec^tm2Gwi/Plec^tm4Gwi Tg(Krt1-5-cre/ERT)1Ipc/?
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plec^tm2Gwi mutation (0 available); any Plec mutation (173 available)
Plec^tm4Gwi mutation (0 available); any Plec mutation (173 available)
Tg(Krt1-5-cre/ERT)1Ipc mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

impaired skin barrier function ( J:124213 )

• following treatment with tamoxifen and tape stripping (10 times), mice exhibit increased transepidermal water loss not observed in control Plec1^tm4Gwi homozygotes

integument

impaired skin barrier function ( J:124213 )

• following treatment with tamoxifen and tape stripping (10 times), mice exhibit increased transepidermal water loss not observed in control Plec1^tm4Gwi homozygotes

blistering ( J:124213 )

• following treatment with tamoxifen and tape stripping (10 times), mice develop small blisters

abnormal skin condition ( J:124213 )

• skin around lesions induced by treatment with tamoxifen and tape stripping (10 times) is more fragile

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

skin inflammation ( J:116380 )

• intra-epidermal T cells, epidermal micro-abscesses and typical inflammatory-cell infiltrate consisting of neutrophils, and an increase in numbers of macrophages in the dermis are seen in mice 8-10 days after tamoxifen induction

abnormal skin morphology ( J:116380 )

• mice treated with tamoxifen show an increase in subepidermal vascularization

hyperkeratosis ( J:116380 )

• thickening of keratinized upper layers in mice treated with tamoxifen

parakeratosis ( J:116380 )

• in mice treated with tamoxifen

thick epidermis ( J:116380 )

• mice treated with tamoxifen show thickened epidermis with prominent rete ridge

psoriasis ( J:116380 )

• mice treated with tamoxifen at 8 weeks of age develop psoriasis-like skin lesions on hairless skin 8-10 days after tamoxifen induction, showing scaly plaques affecting primarily ears, paws and tail, and less frequently the hairy back skin

immune system

increased inflammatory response ( J:116380 )

• periostitis in mice treated with tamoxifen

arthritis ( J:116380 )

• arthritic lesions similar to psoriatic arthritis are seen in 100% of mice treated with tamoxifen, showing inflammatory infiltrates in joint regions

skin inflammation ( J:116380 )

skeleton

arthritis ( J:116380 )

• arthritic lesions similar to psoriatic arthritis are seen in 100% of mice treated with tamoxifen, showing inflammatory infiltrates in joint regions

abnormal bone structure ( J:116380 )

• massive bone destruction

abnormal periosteum morphology ( J:116380 )

• periostitis in mice treated with tamoxifen

cardiovascular system

abnormal blood vessel morphology ( J:116380 )

• mice treated with tamoxifen show an increase in subepidermal vascularization

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
psoriasis		DOID:8893	OMIM:PS177900	J:116380

Allelic Composition	Chuk^tm1Yhu/Chuk^tm1Yhu Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuk^tm1Yhu mutation (0 available); any Chuk mutation (48 available)
Tg(Krt1-5-cre/ERT)1Ipc mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased skin tumor incidence ( J:141162 )

• 10 to 12 months following induction with tamoxifen

integument

epidermal hyperplasia ( J:141162 )

• after tamoxifen induction, mice exhibit dorsal epidermis hyperplasia

increased skin tumor incidence ( J:141162 )

• 10 to 12 months following induction with tamoxifen

Allelic Composition	Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}/Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc} Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc} mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(Krt1-5-cre/ERT)1Ipc mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased basal cell carcinoma incidence ( J:158915 )

• tamoxifen-treated mice develop basal cell carcinomas that are restricted to the epidermis

integument

increased basal cell carcinoma incidence ( J:158915 )

• tamoxifen-treated mice develop basal cell carcinomas that are restricted to the epidermis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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