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Targeted Allele Detail
Symbol: Plectm2Gwi
Name: plectin; targeted mutation 2, Gerhard Wiche
MGI ID: MGI:2181792
Synonyms: exon 2-4-deficient
Gene: Plec  Location: Chr15:76055174-76115578 bp, - strand  Genetic Position: Chr15, 35.48 cM
Alliance: Plectm2Gwi page
Germline Transmission:  Earliest citation of germline transmission: J:59000
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2 through 4 were replaced by a neomycin selection cassette. The 5' end of exon 2 serves as a splice-acceptor site utilized in all four identified alternative transcripts. Transcript was undetected by RT-PCR analysis of samples derived from homozygous mutant skin and muscle tissue. An absence of protein was determined by immunoblot analysis of skin and muscle tissue derived from homozygous mutant mice. (J:59000)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plec Mutation:  100 strains or lines available
Original:  J:59000 Andra K, et al., Targeted inactivation of plectin reveals essential function in maintaining the integrity of skin, muscle, and heart cytoarchitecture. Genes Dev. 1997 Dec 1;11(23):3143-56
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory