Phenotypes associated with this allele

• Allele Symbol: Gli1⁺
• Allele Name: wild type
• Allele ID: MGI:2176804
• Summary: 12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gli1^tm2Alj/Gli1^+	involves: 129S6/SvEvTac * Black Swiss * Swiss Webster	MGI:3795683
cn2	Ctnnb1^tm4Wbm/Ctnnb1^tm4Wbm Gli1^tm3(cre/ERT2)Alj/Gli1^+	involves: 129P2/OlaHsd * 129S6/SvEvTac	MGI:4461250
cn3	Gli1^tm3(cre/ERT2)Alj/Gli1^+ Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor^+ Tnn^tm1b(KOMP)Wtsi/Tnn^tm1b(KOMP)Wtsi	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N	MGI:6694853
cn4	Gt(ROSA)26Sor^tm2(HOXC9)Odk/Gt(ROSA)26Sor^tm2(HOXC9)Odk Gli1^tm3(cre/ERT2)Alj/Gli1^+	involves: 129S6/SvEvTac	MGI:5695620
cn5	Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt Gli1^tm3(cre/ERT2)Alj/Gli1^+	involves: 129S6/SvEvTac * 129X1/SvJ	MGI:4461251
cn6	Gli1^tm3(cre/ERT2)Alj/Gli1^+ Gt(ROSA)26Sor^tm1(Smo/EYFP)Amc/Gt(ROSA)26Sor^+	involves: 129S6/SvEvTac * 129X1/SvJ	MGI:6197800
cn7	Gli1^tm3(cre/ERT2)Alj/Gli1^+ Gt(ROSA)26Sor^tm1(Smo/EYFP)Amc/Gt(ROSA)26Sor^tm1(Smo/EYFP)Amc	involves: 129S6/SvEvTac * 129X1/SvJ	MGI:3810320
cn8	Slfn4^tm1c(EUCOMM)Wtsi/Slfn4^tm1c(EUCOMM)Wtsi Gli1^tm3(cre/ERT2)Alj/Gli1^+	involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * Swiss Webster	MGI:7531280
cn9	Ar^tm2Ska/Y Gli1^tm3(cre/ERT2)Alj/Gli1^+	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:4461249
cx10	Gli1^tm2Alj/Gli1^+ Gli2^tm1Alj/Gli2^tm1Alj Gli3^Xt/Gli3^Xt	involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster	MGI:4414944
cx11	Gli1^tm2Alj/Gli1^+ Gli2^tm1Alj/Gli2^tm1Alj	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster	MGI:3795863
cx12	Gli1^tm1Alj/Gli1^+ Gli2^tm1Alj/Gli2^tm1Alj	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3614423

Genotype
MGI:3795683

ht1

• Allelic Composition: Gli1^tm2Alj/Gli1⁺
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss * Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:112460 )

N • embryos show normal mammary gland development

Genotype
MGI:4461250

cn2

• Allelic Composition: Ctnnb1^tm4Wbm/Ctnnb1^tm4Wbm; Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

reproductive system

abnormal external male genitalia morphology ( J:148515 )

♂ • 40% of tamoxifen-treated male mice fail to develop a proper prepuce and ventral midline formation unlike wild-type mice

♂ • however, development of female genital tracts is normal

abnormal foreskin morphology ( J:148515 )

♂ • 40% of tamoxifen-treated male mice fail to develop a proper prepuce unlike wild-type mice

renal/urinary system

abnormal foreskin morphology ( J:148515 )

♂ • 40% of tamoxifen-treated male mice fail to develop a proper prepuce unlike wild-type mice

Genotype
MGI:6694853

cn3

• Allelic Composition: Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺; Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺; Tnn^{tm1b(KOMP)Wtsi}/Tnn^{tm1b(KOMP)Wtsi}
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N

craniofacial

abnormal tooth development ( J:302206 )

• after tamoxifen injection, lineage tracing experiments revealed differentiation and proliferation defects in the incisor stem cell compartment at 3 months of age

• GFP+ Gli1 expressing cells are decreased in number and in area in the incisor pulp, indicating decreased hedgehog signaling

• Ki67 immunostaining showed that the proliferation rate of putative mesenchymal stem cells is reduced

growth/size/body

abnormal tooth development ( J:302206 )

• after tamoxifen injection, lineage tracing experiments revealed differentiation and proliferation defects in the incisor stem cell compartment at 3 months of age

• GFP+ Gli1 expressing cells are decreased in number and in area in the incisor pulp, indicating decreased hedgehog signaling

• Ki67 immunostaining showed that the proliferation rate of putative mesenchymal stem cells is reduced

skeleton

abnormal tooth development ( J:302206 )

• after tamoxifen injection, lineage tracing experiments revealed differentiation and proliferation defects in the incisor stem cell compartment at 3 months of age

• GFP+ Gli1 expressing cells are decreased in number and in area in the incisor pulp, indicating decreased hedgehog signaling

• Ki67 immunostaining showed that the proliferation rate of putative mesenchymal stem cells is reduced

Genotype
MGI:5695620

cn4

• Allelic Composition: Gt(ROSA)26Sor^{tm2(HOXC9)Odk}/Gt(ROSA)26Sor^{tm2(HOXC9)Odk}; Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺
• Genetic Background: involves: 129S6/SvEvTac

craniofacial

craniofacial phenotype ( J:201472 )

N • size of the labial cervical loop at the proximal end of the incisor is not affected after tamoxifen injection

Genotype
MGI:4461251

cn5

• Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt; Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺
• Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

reproductive system

abnormal external female genitalia morphology ( J:148515 )

♀ • female tamoxifen-treated mice exhibit well-developed prepuce unlike wild-type female mice

♀ • adult tamoxifen-treated mice exhibit a hyperplasic prepuce with enlarged external genitalia similar to male mice unlike wild-type female mice

♀ • however, the scrotal/perineal region is normal

Genotype
MGI:6197800

cn6

• Allelic Composition: Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺; Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

respiratory system

respiratory system phenotype ( J:264185 )

N • tamoxifen-treated mice do not exhibit distal airspace morphological changes

Genotype
MGI:3810320

cn7

• Allelic Composition: Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺; Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}/Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}
• Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

mortality/aging

premature death ( J:139574 )

• mice survive 45 days

neoplasm

increased medulloblastoma incidence ( J:139574 )

• all mice develop medulloblastomas that are located in lobes VI through IX and have a mean survival of 45 days

nervous system

increased medulloblastoma incidence ( J:139574 )

• all mice develop medulloblastomas that are located in lobes VI through IX and have a mean survival of 45 days

Genotype
MGI:7531280

cn8

• Allelic Composition: Slfn4^{tm1c(EUCOMM)Wtsi}/Slfn4^{tm1c(EUCOMM)Wtsi}; Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * Swiss Webster
• Cell Lines: EPD0746_4_G08

digestive/alimentary system

abnormal stomach mucosa morphology ( J:337060 )

• at 4 months after inoculation with Helicobacter felis (H. felis), tamoxifen-treated mice develop significantly less Helicobacter-induced spasmolytic polypeptide-expressing metaplasia (SPEM) than 4-month-infected wild-type controls, as shown by reduced GSII-lectin staining and recovery of some H⁺, K⁺ -ATPase⁺ parietal cells

immune system

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:337060 )

• H. felis-infected tamoxifen-treated mice show an increased population of CD8⁺ cytotoxic T cells in the stomach relative to infected wild-type controls

abnormal interleukin level ( J:337060 )

• H. felis-infected tamoxifen-treated mice show decreased gastric interleukin-1 alpha (IL1a) levels relative to infected controls

abnormal tumor necrosis factor level ( J:337060 )

• H. felis-infected tamoxifen-treated mice show decreased gastric TNF levels relative to infected controls

decreased susceptibility to bacterial infection ( J:337060 )

• H. felis-infected tamoxifen-treated mice show attenuated Helicobacter-induced gastric metaplasia relative to infected wild-type controls

homeostasis/metabolism

abnormal interleukin level ( J:337060 )

• H. felis-infected tamoxifen-treated mice show decreased gastric interleukin-1 alpha (IL1a) levels relative to infected controls

abnormal tumor necrosis factor level ( J:337060 )

• H. felis-infected tamoxifen-treated mice show decreased gastric TNF levels relative to infected controls

hematopoietic system

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:337060 )

• H. felis-infected tamoxifen-treated mice show an increased population of CD8⁺ cytotoxic T cells in the stomach relative to infected wild-type controls

Genotype
MGI:4461249

cn9

• Allelic Composition: Ar^tm2Ska/Y; Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

reproductive system

abnormal external male genitalia morphology ( J:148515 )

♂ • tamoxifen-treated mice exhibit hypoplastic external genitalia compared with wild-type mice

♂ • external genitalis of tamoxifen-treated mice are feminized

abnormal foreskin morphology ( J:148515 )

♂ • underdeveloped in tamoxifen-treated mice

abnormal reproductive system development ( J:148515 )

♂ • prospective corporal bodies from tamoxifen-treated mice fail to differentiate or bilaterally segment in the mesenchyme unlike in wild-type mice

♂ • however, development of internal reproductive organs are normally in tamoxifen-treated mice

renal/urinary system

abnormal foreskin morphology ( J:148515 )

♂ • underdeveloped in tamoxifen-treated mice

Genotype
MGI:4414944

cx10

• Allelic Composition: Gli1^tm2Alj/Gli1⁺; Gli2^tm1Alj/Gli2^tm1Alj; Gli3^Xt/Gli3^Xt
• Genetic Background: involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster

nervous system

abnormal neuron differentiation ( J:87948 )

• progenitors for motor neurons, V1 and V2 interneurons are present but intermixed indicating abnormal spatial patterning

abnormal neuronal precursor proliferation ( J:87948 )

• increased proliferation of ventral spinal cord progenitors at E10.5

absent floor plate ( J:87948 )

• floor plate progenitors are missing

abnormal neuronal precursor cell number ( J:87948 )

• incorrect positioning and number of V0-V2 and motor neuron progenitors at E9.5

abnormal spinal cord morphology ( J:87948 )

• ventral spinal cord is expanded resulting in a wavy appearance

abnormal motor neuron morphology ( J:87948 )

• distribution of motor neurons varies at E12.5

decreased motor neuron number ( J:87948 )

• reduction in the number of differentiated motor neurons but an increase in their progenitors

abnormal ventral interneuron morphology ( J:87948 )

• absence of V3 progenitors and interneurons, however V0-V2 cells are formed

• fewer V2, V1, and V0 interneurons are seen in the hindlimb

abnormal ventral interneuron 3 morphology ( J:87948 )

• absence of V3 progenitors and interneurons, however V0-V2 cells are formed

embryo

absent floor plate ( J:87948 )

• floor plate progenitors are missing

cellular

abnormal neuron differentiation ( J:87948 )

• progenitors for motor neurons, V1 and V2 interneurons are present but intermixed indicating abnormal spatial patterning

abnormal neuronal precursor proliferation ( J:87948 )

• increased proliferation of ventral spinal cord progenitors at E10.5

Genotype
MGI:3795863

cx11

• Allelic Composition: Gli1^tm2Alj/Gli1⁺; Gli2^tm1Alj/Gli2^tm1Alj
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster

respiratory system

small lung ( J:79392 )

• at E12.5 lungs are smaller than in wild-type

Genotype
MGI:3614423

cx12

• Allelic Composition: Gli1^tm1Alj/Gli1⁺; Gli2^tm1Alj/Gli2^tm1Alj
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

respiratory system

abnormal lung morphology ( J:60986 )

• at E12.5 and E18.5, lungs appear to have 2 small lobes

small lung ( J:60986 )

• at E12.5 and E18.5, lungs appear smaller than normal