All Phenotypes Bdnf<+> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bdnf⁺
wild type
MGI:2158290

Summary

16 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Bdnf^tm1Flee/Bdnf⁺	B6.129-Bdnf^tm1Flee	MGI:3664864
ht2	Bdnf^tm1Par/Bdnf⁺	B6.129S1-Bdnf^tm1Par	MGI:3664866
ht3	Bdnf^tm1.1Tmiz/Bdnf⁺	B6.Cg-Bdnf^tm1.1Tmiz	MGI:7547009
ht4	Bdnf^tm1Gdy/Bdnf⁺	involves: 129P2/OlaHsd	MGI:3703791
ht5	Bdnf^tm1Par/Bdnf⁺	involves: 129S1/Sv	MGI:3664865
ht6	Bdnf^tm1.1Krj/Bdnf⁺	involves: 129S2/SvPas * C57BL/6	MGI:5427384
ht7	Bdnf^tm1Lfr/Bdnf⁺	involves: 129S2/SvPas * C57BL/6J	MGI:3584259
ht8	Bdnf^tm1Tbn/Bdnf⁺	involves: 129S4/SvJae * NMRI	MGI:2175724
ht9	Bdnf^tm1Jben/Bdnf⁺	involves: C57BL/6	MGI:3721578
cn10	Bdnf^tm1Krj/Bdnf⁺ Emx1^tm1(cre)Krj/Emx1⁺	involves: 129S2/SvPas * C57BL/6J	MGI:3584257
cn11	Bdnf^tm3Jae/Bdnf⁺ Mecp2^tm1.1Jae/Y Tg(Camk2a-cre)93Kln/0	involves: 129S4/SvJae * C57BL/6 * CBA/J	MGI:5306256
cx12	Bdnf^tm1Par/Bdnf⁺ Ntrk2^tm1.1Tes/Ntrk2^tm1.1Tes	B6.129S1-Bdnf^tm1Par Ntrk2^tm1.1Tes	MGI:3833380
cx13	Bdnf^tm1Par/Bdnf⁺ Ntrk2^tm1.1Tes/Ntrk2⁺	B6.129S1-Bdnf^tm1Par Ntrk2^tm1.1Tes	MGI:3833382
cx14	Bdnf^tm1Jae/Bdnf⁺ Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-tetX,lacZ)2Gogo/?	involves: 129S4/SvJae * C57BL/6	MGI:3723444
cx15	Bdnf^{tm2(BDNF)Gogo}/Bdnf⁺ Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-tetX,lacZ)2Gogo/?	involves: 129S/SvEv	MGI:3723439
cx16	Bdnf^{tm1(BDNF)Gogo}/Bdnf⁺ Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-tetX,lacZ)2Gogo/?	involves: 129S/SvEv	MGI:3723437

Allelic Composition	Bdnf^tm1Flee/Bdnf⁺
Genetic Background	B6.129-Bdnf^tm1Flee

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Flee mutation (0 available); any Bdnf mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal contextual conditioning behavior ( J:113019 )

• impaired context dependent learning but no difference in cue-dependent learning

nervous system

abnormal dentate gyrus morphology ( J:113019 )

• reduction in dendritic arbor complexity at or above 90 uM from the soma

decreased hippocampus volume ( J:113019 )

• 13.7 +/- 0.7% reduction in hippocampal volume

abnormal dendrite morphology ( J:113019 )

• reduction in dendritic arbor complexity at or above 90 uM from the soma in dentate gyrus neurons

abnormal neuron physiology ( J:113019 )

• hippocampal-cortical neurons display a 18 +/- 2% decrease in regulated secretion, but no decrease in constitutive secretion, of BDNF

Allelic Composition	Bdnf^tm1Par/Bdnf⁺
Genetic Background	B6.129S1-Bdnf^tm1Par

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Par mutation (0 available); any Bdnf mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

polyphagia ( J:59077 )

• age-related increase in food intake beggining around 6 weeks of age

• by 4-7 months of age mice consume about 25% more food than wild-type littermates

• chronic fluoxetine treatment partially suppresses hyperphagia

increased aggression towards male mice ( J:59077 , J:144845 )

• decrease in latency to attack an intruder and increase in number of biting attacks (J:59077)

• latency to attack progressively decreases over repeated trials (J:59077)

• treatment with fluoxetine reduced aggression to a level similar to that in wild-type mice (J:59077)

• male mice have decreased latency time to first biting attack against intruder males compared to wild-type controls (J:144845)

• male mice also have a significantly increased number of biting attacks over a 5 minute period (J:144845)

abnormal locomotor activation ( J:59077 )

• increased time spent in the center area during a 10 minute period in and open field; however, overall locomotor activity in an open field is not different from wild-type

decreased vertical activity ( J:59077 )

• during a 10 minute trial in an open field

growth/size/body

increased body weight ( J:144845 )

• mice gain weight with age with a mean 10 gram difference occurring by 6 months of age

increased susceptibility to age related obesity ( J:59077 )

• first detected at 2-4 months of age and by 12-18 months of age body weight is 34% higher than wild-type littermates

nervous system

abnormal serotonergic neuron morphology ( J:59077 )

• progressive loss of serotonin axons is seen in 12 to 18 month old mice

abnormal CNS synaptic transmission ( J:59077 )

• abnormal induction of Fos by dexfenfluramine (reduced in the bed nucleus of the stria terminalis, the central nucleus of the amygdala, parts of the caudate-putamen, the shell region of the nucleus accumbens, and the thalamic nuclei; increased in the pyramidal neurons of the hippocampus) indicates abnormal neuronal activation induced by 5-HT release

homeostasis/metabolism

increased circulating insulin level ( J:59077 )

• about 2-fold higher at 12 months of age

abnormal serotonin level ( J:59077 )

• forebrain levels of 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) are significantly lower in old but not in young mice

• at 18 months of age the ratio of 5-HIAA to 5-HT is lower in the hypothalamus

Allelic Composition	Bdnf^tm1.1Tmiz/Bdnf⁺
Genetic Background	B6.Cg-Bdnf^tm1.1Tmiz

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1.1Tmiz mutation (0 available); any Bdnf mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased food intake ( J:303078 )

• after social isolation between age 6 and 14 weeks

behavioral despair ( J:303078 )

• increased immobility in tail suspension test after social isolation between age 6 and 14 weeks

abnormal nest building behavior ( J:303078 )

• after social isolation between age 6 and 14 weeks

growth/size/body

increased body weight ( J:303078 )

• after social isolation between age 6 and 14 weeks

Allelic Composition	Bdnf^tm1Gdy/Bdnf⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Gdy mutation (0 available); any Bdnf mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

small vestibular ganglion ( J:110692 )

• at E16.5-E17, heterozygotes show an ~50% reduction in vestibular ganglion size relative to wild-type mice

• in addition, the average diameter of heterozygous vestibular neurons is slightly decreased

vestibular ganglion degeneration ( J:110692 )

• from E16.5 to P15, heterozygous display an ~50% reduction in vestibular ganglion volume and neuronal number relative to wild-type mice

Allelic Composition	Bdnf^tm1Par/Bdnf⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Par mutation (0 available); any Bdnf mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased exploration in new environment ( J:113019 )

• decreased exploratory behavior as measured by percentage of time spent in the center and number of entries into the center of and open field over a 2 hour period; however no significant change in total locomotor activity is detected

increased aggression towards male mice ( J:113019 )

• increase in intermale aggression

increased anxiety-related response ( J:113019 )

• decrease in time spent in the open arms and numbers of entries into the open arms in an elevated plus maze

nervous system

decreased hippocampus volume ( J:113019 )

• 13.8 +/- 0.6% reduction in hippocampal volume

growth/size/body

increased body weight ( J:113019 )

• first detected at 2 months of age

Allelic Composition	Bdnf^tm1.1Krj/Bdnf⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1.1Krj mutation (0 available); any Bdnf mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:184139 )

N	• whole apical and basal spine density in the visual cortex is normal at 3 weeks of age • distal segment density of both basal and apical dendrites is normal at 4 months of age

abnormal dendritic spine morphology ( J:184139 )

• spine head diameter fails to increase as it does in controls

Allelic Composition	Bdnf^tm1Lfr/Bdnf⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Lfr mutation (1 available); any Bdnf mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

obese ( J:84683 )

• an 85% increase in body mass is seen at 8 weeks of age

Allelic Composition	Bdnf^tm1Tbn/Bdnf⁺
Genetic Background	involves: 129S4/SvJae * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Tbn mutation (0 available); any Bdnf mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

impaired synaptic plasticity ( J:64962 )

• frequency distributions of posttetanic synaptic enhancements indicate that in heterozygotes most potentiations are close to 100% vs >150% in wild-type mice

• after P16, heterozygotes display almost no differences in posttetanic synaptic strengthening relative to homozygotes

abnormal excitatory postsynaptic potential ( J:64962 )

• after tetanic stimulation, heterozygotes exhibit a similar reduction in mean field EPSP slopes to that observed in homozygotes

• as in homozygotes, paired pulse facilitation (ratio of second EPSP slope to first EPSP slope) is unaffected

reduced long-term potentiation ( J:64962 )

• heterozygotes display a similar reduction in LTP magnitude and % of successful LTPs in the CA1 region of the hippocampus to that observed in homozygotes

• again, the magnitude of potentiation is significantly smaller than in wild-type mice and declines slowly over time

• in contrast to homozygotes, heterozygotes are viable and display normal dorsal root ganglia and no balance or coordination deficits

Allelic Composition	Bdnf^tm1Jben/Bdnf⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Jben mutation (0 available); any Bdnf mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal striatum morphology ( J:111309 )

• neurons in the striatum have less spines on distal dendrites at 24 months of age

abnormal neuron morphology ( J:111309 )

• neurons in the striatum have less spines on distal dendrites at 24 months of age

behavior/neurological

decreased locomotor activity ( J:111309 )

• at 3 months and 24 months of age, mice exhibit less horizontal active over a 1 hour period of the light cycle

growth/size/body

weight loss ( J:111309 )

• mice start to lose weight at 12 months and by 24 months mice only weigh as much as at 18 and 12 months of age

Allelic Composition	Bdnf^tm1Krj/Bdnf⁺ Emx1^tm1(cre)Krj/Emx1⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Krj mutation (1 available); any Bdnf mutation (42 available)
Emx1^tm1(cre)Krj mutation (2 available); any Emx1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:84683 )

N	• forebrain specific heterozygotes do not become obese unlike mice heterozygous for Bdnf^tm1Lfr

Allelic Composition	Bdnf^tm3Jae/Bdnf⁺ Mecp2^tm1.1Jae/Y Tg(Camk2a-cre)93Kln/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm3Jae mutation (2 available); any Bdnf mutation (42 available)
Mecp2^tm1.1Jae mutation (2 available); any Mecp2 mutation (43 available)
Tg(Camk2a-cre)93Kln mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:106973 )

• life span is shorter than in Mecp2 single hemizygous mice but longer than in mutant mice homozygous for the Bdnf allele

Allelic Composition	Bdnf^tm1Par/Bdnf⁺ Ntrk2^tm1.1Tes/Ntrk2^tm1.1Tes
Genetic Background	B6.129S1-Bdnf^tm1Par Ntrk2^tm1.1Tes

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Par mutation (0 available); any Bdnf mutation (42 available)
Ntrk2^tm1.1Tes mutation (0 available); any Ntrk2 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased aggression towards male mice ( J:144845 )

• male mice have decreased latency time to first biting attack against intruder males compared to wild-type controls

• male mice also have a significantly increased number of biting attacks over a 5 minute period

• the latency time and number of attacks are not to the same degree as mice that only carry the Bdnf^tm1Par mutant allele

growth/size/body

increased body weight ( J:144845 )

• mice gain weight with age though not to the degree as mice that only carry the Bdnf^tm1Par mutant allele

Allelic Composition	Bdnf^tm1Par/Bdnf⁺ Ntrk2^tm1.1Tes/Ntrk2⁺
Genetic Background	B6.129S1-Bdnf^tm1Par Ntrk2^tm1.1Tes

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased aggression towards male mice ( J:144845 )

• male mice have decreased latency time to first biting attack against intruder males compared to wild-type controls

• male mice also have a significantly increased number of biting attacks over a 5 minute period

• the latency time and number of attacks are not to the same degree as mice that only carry the Bdnf^tm1Par mutant allele

Allelic Composition	Bdnf^tm1Jae/Bdnf⁺ Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-tetX,lacZ)2Gogo/?
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Jae mutation (2 available); any Bdnf mutation (42 available)
Omp^tm1(tTA)Gogo mutation (1 available); any Omp mutation (26 available)
Tg(tetO-tetX,lacZ)2Gogo mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:124050 )

N	• following doxycycline treatment, terminal-arbor complexity of olfactory nerves is normal

Allelic Composition	Bdnf^{tm2(BDNF)Gogo}/Bdnf⁺ Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-tetX,lacZ)2Gogo/?
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^{tm2(BDNF)Gogo} mutation (0 available); any Bdnf mutation (42 available)
Omp^tm1(tTA)Gogo mutation (1 available); any Omp mutation (26 available)
Tg(tetO-tetX,lacZ)2Gogo mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory nerve morphology ( J:124050 )

• following doxycycline treatment, terminal-arbor complexity at P6 is reduced similar to in Tg(tetO-tetX,lacZ)2Gogo Omp^tm1(tTA)Gogo mice

Allelic Composition	Bdnf^{tm1(BDNF)Gogo}/Bdnf⁺ Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-tetX,lacZ)2Gogo/?
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^{tm1(BDNF)Gogo} mutation (0 available); any Bdnf mutation (42 available)
Omp^tm1(tTA)Gogo mutation (1 available); any Omp mutation (26 available)
Tg(tetO-tetX,lacZ)2Gogo mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:124050 )

N	• following doxycycline treatment, terminal-arbor complexity and total length of olfactory nerve axons is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24