Bdnf^tm1Flee
Targeted Allele Detail

Summary

• Symbol: Bdnf^tm1Flee
• Name: brain derived neurotrophic factor; targeted mutation 1, Francis S Lee
• MGI ID: MGI:3664862
• Synonyms: BDNF^M, BDNF^Met, BDNF Val66Met
• Gene: Bdnf Location: Chr2:109505045-109557352 bp, + strand Genetic Position: Chr2, 56.63 cM
• Alliance: Bdnf^tm1Flee page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113019
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A V66M mutation was introduced into the prodomain via homologous recombination. The PGK-neo selection cassette was removed by crossing to a Cre strain with expression at one-cell zygote stage. Total expression of protein in brain lysates is similar to wild-type. (J:113019)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bdnf Mutation: 42 strains or lines available

References

• Original: J:113019 Chen ZY, et al., Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science. 2006 Oct 6;314(5796):140-3
• All: 29 reference(s)