Phenotypes associated with this allele

• Allele Symbol: Atoh1^tm1Hzo
• Allele Name: targeted mutation 1, Huda Y Zoghbi
• Allele ID: MGI:2155984
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atoh1^tm1Hzo/Atoh1^tm1Hzo	involves: 129S7/SvEvBrd	MGI:2183423
cn2	Atoh1^tm3Hzo/Atoh1^tm1Hzo Gt(ROSA)26Sor^tm1(cre/ERT)Nat/Gt(ROSA)26Sor^+	involves: 129 * 129S7/SvEvBrd	MGI:4420931
cn3	Atoh1^tm3Hzo/Atoh1^tm1Hzo Gt(ROSA)26Sor^tm1(cre/ERT)Nat/Gt(ROSA)26Sor^tm1(Smo/EYFP)Amc	involves: 129 * 129S7/SvEvBrd * 129X1/SvJ	MGI:4420935

Genotype
MGI:2183423

hm1

• Allelic Composition: Atoh1^tm1Hzo/Atoh1^tm1Hzo
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:44241 )

• animals die shortly after birth

homeostasis/metabolism

cyanosis ( J:44241 )

respiratory system

respiratory failure ( J:44241 )

• animals do not breathe after birth

nervous system

absent cerebellar foliation ( J:44241 )

abnormal cerebellum external granule cell layer morphology ( J:44241 )

• absent external granule layer: migrating granule cells absent as early as E14 in rhombic lip

abnormal cerebellar Purkinje cell layer ( J:44241 )

• disorganized and cells localized at periphery of cerebellum

small cerebellum ( J:44241 )

• cerebellum is smaller, however the nucleus tractus solitarus, nucleus ambiguus, dorsal vagus nucleus and trigeminal ganglion of the hindbrain are normal

Genotype
MGI:4420931

cn2

• Allelic Composition: Atoh1^tm3Hzo/Atoh1^tm1Hzo; Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129 * 129S7/SvEvBrd

nervous system

thin external granule cell layer ( J:155047 )

• after tamoxifen treatment, the external granule cell layer is much thinner than that of control littermates

• after tamoxifen treatment, the layer is depleted of cycling immature precursors

Genotype
MGI:4420935

cn3

• Allelic Composition: Atoh1^tm3Hzo/Atoh1^tm1Hzo; Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}
• Genetic Background: involves: 129 * 129S7/SvEvBrd * 129X1/SvJ

nervous system

abnormal neuronal precursor proliferation ( J:155047 )

• no cycling granule neuron precursor cells are detected in the external granule cell layer 10 days after tamoxifen treatment

thin external granule cell layer ( J:155047 )

• 10 days after tamoxifen treatment

cerebellum atrophy ( J:155047 )

• 10 days after tamoxifen treatment most mice have atrophic cerebella

cellular

abnormal neuronal precursor proliferation ( J:155047 )

• no cycling granule neuron precursor cells are detected in the external granule cell layer 10 days after tamoxifen treatment