All Phenotypes Hoxa11<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hoxa11⁺
wild type
MGI:2137146

Summary

17 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hoxa11^{tm2.1(Hoxa13)Ssp}/Hoxa11⁺	either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)	MGI:3810947
ht2	Hoxa11^tm1Ssp/Hoxa11⁺	involves: 129S2/SvPas * C57BL/6J	MGI:3718237
ht3	Hoxa11^tm1Ssp/Hoxa11⁺	involves: 129S2/SvPas * CF-1	MGI:2178118
ht4	Hoxa11^tm1Mrc/Hoxa11⁺	Not Specified	MGI:3810824
cx5	Hoxa11^tm1Dmwe/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11⁺	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6	MGI:3814866
cx6	Hoxa11^tm1Ssp/Hoxa11⁺ Hoxd^tm3Ddu/Hoxd⁺	involves: 129S2/SvPas * C57BL/6 * CF-1 * SJL	MGI:2178137
cx7	Hoxa11^tm1Ssp/Hoxa11⁺ Hoxd^tm3Ddu/Hoxd^tm3Ddu	involves: 129S2/SvPas * C57BL/6 * CF-1 * SJL	MGI:2178138
cx8	Hoxa11^tm1Ssp/Hoxa11⁺ Hoxd11^tm2.1Ddu/Hoxd11⁺	involves: 129S2/SvPas * C57BL/6J	MGI:3718236
cx9	Hoxa11^tm1Ssp/Hoxa11⁺ Hoxd11^tm2.1Ddu/Hoxd11^tm2.1Ddu	involves: 129S2/SvPas * C57BL/6J	MGI:3718231
cx10	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11^tm1Mrc	involves: 129S7/SvEvBrd	MGI:3814879
cx11	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11⁺	involves: 129S7/SvEvBrd	MGI:3814871
cx12	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxd11^tm1Mrc/Hoxd11^tm1Mrc	involves: 129S7/SvEvBrd	MGI:3810827
cx13	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxd11^tm1Mrc/Hoxd11⁺	involves: 129S7/SvEvBrd	MGI:3810825
cx14	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11⁺	involves: 129S7/SvEvBrd	MGI:3814873
cx15	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11^tm1Mrc	involves: 129S7/SvEvBrd	MGI:3814874
cx16	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxd11^{tm2.1(Hoxd11)Mrc}/Hoxd11^{tm2.1(Hoxd11)Mrc}	involves: BALB/cJ	MGI:3810839
cx17	Hoxa11^tm1Ssp/Hoxa11⁺ Hoxd11^tm1Mrc/Hoxd11⁺	mixed	MGI:2172332

Allelic Composition	Hoxa11^{tm2.1(Hoxa13)Ssp}/Hoxa11⁺
Genetic Background	either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11^{tm2.1(Hoxa13)Ssp} mutation (0 available); any Hoxa11 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

absent endometrial glands ( J:71402 )

• mice lack uterine glands

female infertility ( J:71402 )

limbs/digits/tail

limbs/digits/tail phenotype ( J:71402 )

N	• forelimb morphology is normal

abnormal calcaneum morphology ( J:71402 )

• 7% of mice exhibit a reduction in the calcaneus bone compared to in wild-type mice

abnormal hindlimb zeugopod morphology ( J:71402 )

• mice exhibit a separation in the distal tibia and fibula unlike in wild-type mice

skeleton

abnormal calcaneum morphology ( J:71402 )

• 7% of mice exhibit a reduction in the calcaneus bone compared to in wild-type mice

endocrine/exocrine glands

absent endometrial glands ( J:71402 )

• mice lack uterine glands

Allelic Composition	Hoxa11^tm1Ssp/Hoxa11⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11^tm1Ssp mutation (0 available); any Hoxa11 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal carpal bone morphology ( J:41828 )

• 6 of 9 mice have carpal bone defects

increased lumbar vertebrae number ( J:41828 )

• 1 of 9 mice have abnormal L7 formula instead of an L6 formula found in wild-type mice

limbs/digits/tail

abnormal carpal bone morphology ( J:41828 )

• 6 of 9 mice have carpal bone defects

Allelic Composition	Hoxa11^tm1Ssp/Hoxa11⁺
Genetic Background	involves: 129S2/SvPas * CF-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11^tm1Ssp mutation (0 available); any Hoxa11 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal rib morphology ( J:16079 )

• normal number of ribs, but one rudimentary rib

thoracic vertebral transformation ( J:16079 )

• transformation of the thirteenth thoracic (T13) vertebra to the first lumbar (L1) vertebra

• ~ 50% penetrance

reproductive system

abnormal uterine environment ( J:25252 )

• heterozygous mutant uteri are only marginally capable of supporting embryonic development to term

• only 165 living embryos out of a total of 480 implantation sites are detected at 10.5 and 11.5 of gestation

decreased litter size ( J:25252 )

• heterozygous females produce severely reduced litter sizes

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11^tm1Mrc mutation (0 available); any Hoxa11 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:78766 )

N	• mice exhibit a normal number of lumbar vertebrae

Allelic Composition	Hoxa11^tm1Dmwe/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11⁺
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11^tm1Dmwe mutation (1 available); any Hoxa11 mutation (10 available)
Hoxc11^tm1Mrc mutation (0 available); any Hoxc11 mutation (14 available)
Hoxd11^tm1Mrc mutation (0 available); any Hoxd11 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

female infertility ( J:140709 )

male infertility ( J:140709 )

Allelic Composition	Hoxa11^tm1Ssp/Hoxa11⁺ Hoxd^tm3Ddu/Hoxd⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6 * CF-1 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11^tm1Ssp mutation (0 available); any Hoxa11 mutation (10 available)
Hoxd^tm3Ddu mutation (0 available); any Hoxd mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:47900 )

N	• normal morphology of the ulna, radius, tibia, and fibula

Allelic Composition	Hoxa11^tm1Ssp/Hoxa11⁺ Hoxd^tm3Ddu/Hoxd^tm3Ddu
Genetic Background	involves: 129S2/SvPas * C57BL/6 * CF-1 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal radius morphology ( J:47900 )

abnormal ulna morphology ( J:47900 )

abnormal fibula morphology ( J:47900 )

• lack of distal fusion of tibia and fibula

abnormal tibia morphology ( J:47900 )

• lack of distal fusion of tibia and fibula

skeleton

abnormal radius morphology ( J:47900 )

abnormal ulna morphology ( J:47900 )

abnormal fibula morphology ( J:47900 )

• lack of distal fusion of tibia and fibula

abnormal tibia morphology ( J:47900 )

• lack of distal fusion of tibia and fibula

Allelic Composition	Hoxa11^tm1Ssp/Hoxa11⁺ Hoxd11^tm2.1Ddu/Hoxd11⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11^tm1Ssp mutation (0 available); any Hoxa11 mutation (10 available)
Hoxd11^tm2.1Ddu mutation (0 available); any Hoxd11 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal carpal bone morphology ( J:41828 )

• 1 of 11 mice have carpal bone defects

abnormal lumbar vertebrae morphology ( J:41828 )

• 7 of 11 mice have abnormal L4

• 1 of 11 mice have abnormal L6

increased lumbar vertebrae number ( J:41828 )

• 2 of 11 mice have an L7 formula instead of an L6 formula found in wild-type mice

limbs/digits/tail

abnormal carpal bone morphology ( J:41828 )

• 1 of 11 mice have carpal bone defects

Allelic Composition	Hoxa11^tm1Ssp/Hoxa11⁺ Hoxd11^tm2.1Ddu/Hoxd11^tm2.1Ddu
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal lumbar vertebrae morphology ( J:41828 )

• 11 of 11 mice have abnormal L4

• 4 of 11 mice have abnormal L6

increased lumbar vertebrae number ( J:41828 )

• 7 of 11 mice have an L7 formula instead of an L6 formula found in wild-type mice

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11^tm1Mrc mutation (0 available); any Hoxa11 mutation (10 available)
Hoxc11^tm1Mrc mutation (0 available); any Hoxc11 mutation (14 available)
Hoxd11^tm1Mrc mutation (0 available); any Hoxd11 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal hypoplasia ( J:88686 )

• hypoplasia is more severe than in mice with 4 mutant alleles

ectopic kidney ( J:88686 )

• kidneys, when present, are in a more caudal and ventral location

single kidney ( J:88686 )

• occasionally seen

• more frequent than in mice with 4 mutant alleles

abnormal ureteric bud invasion ( J:88686 )

• at E11.5, the bud forms but frequently migrates away from the metanephric mesenchyme

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal reproductive system morphology ( J:88686 )

• show reproductive defects similar to those of mice homozygous for Hoxa11^tm1Mrc

female infertility ( J:88686 )

male infertility ( J:88686 )

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxd11^tm1Mrc/Hoxd11^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11^tm1Mrc mutation (0 available); any Hoxa11 mutation (10 available)
Hoxd11^tm1Mrc mutation (0 available); any Hoxd11 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased lumbar vertebrae number ( J:78766 )

• 7 instead of 6

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxd11^tm1Mrc/Hoxd11⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased lumbar vertebrae number ( J:78766 )

• 7 instead of 6

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal reproductive system morphology ( J:88686 )

• show reproductive defects similar to those of mice homozygous for Hoxa11^tm1Mrc

female infertility ( J:88686 )

male infertility ( J:88686 )

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal reproductive system morphology ( J:88686 )

• show reproductive defects similar to those of mice homozygous for Hoxa11^tm1Mrc

female infertility ( J:88686 )

male infertility ( J:88686 )

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxd11^{tm2.1(Hoxd11)Mrc}/Hoxd11^{tm2.1(Hoxd11)Mrc}
Genetic Background	involves: BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11^tm1Mrc mutation (0 available); any Hoxa11 mutation (10 available)
Hoxd11^{tm2.1(Hoxd11)Mrc} mutation (0 available); any Hoxd11 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:78766 )

N	• mice exhibit a normal number of lumbar vertebrae

Allelic Composition	Hoxa11^tm1Ssp/Hoxa11⁺ Hoxd11^tm1Mrc/Hoxd11⁺
Genetic Background	mixed

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11^tm1Ssp mutation (0 available); any Hoxa11 mutation (10 available)
Hoxd11^tm1Mrc mutation (0 available); any Hoxd11 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

fused carpal bones ( J:26492 )

• proximal carpal bones are fused

• one additional mutant allele at either locus leads to carpal malformation as well

sacral vertebral transformation ( J:26492 )

• homeotic transformation of first sacral vertebra to lumbar vertebra 7

limbs/digits/tail

fused carpal bones ( J:26492 )

• proximal carpal bones are fused

• one additional mutant allele at either locus leads to carpal malformation as well

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