Analysis Tools|
Allele Symbol Allele Name Allele ID |
Trim28tm1.1Ipc targeted mutation 1.1, Pierre Chambon MGI:1928907 |
||||||||||||||||||||||||
| Summary |
5 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• follicles organized into pseudo-tubular structures (masculinization: transdifferentiation of granulosa cells into Sertoli cells) at age 8 weeks
|
|
• follicles organized into pseudo-tubular structures (masculinization: transdifferentiation of granulosa cells into Sertoli cells) at age 8 weeks
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• medullar follicles organized into pseudo-tubular structures (masculinization: transdifferentiation of granulosa cells into Sertoli cells) at age 8 weeks
• remodeling (masculinization) of cortical follicles started by age 8 weeks, though follicles still organized
• all follicles masculinized at age 4 months
|
|
• medullar follicles organized into pseudo-tubular structures (masculinization: transdifferentiation of granulosa cells into Sertoli cells) at age 8 weeks
• remodeling (masculinization) of cortical follicles started by age 8 weeks, though follicles still organized
• all follicles masculinized at age 4 months
|
| N |
• normal apoptosis in ovaries at ages P20 and 8 weeks
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• embryos no normal yolk sac protrusions or trophoblast malformations
|
|
• at E8.5
|
|
• shorter and wider than in control mice
|
|
• failure of gut closure
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 N |
• no defects are detected in Sertoli cell or spermatogonia proliferation at P5
|
|
|
• spermatids fail to align at the luminal side of the seminiferous tubules at stage VII of the epithelial cycle
|
|
|
• decrease in the number of mature spermatids
|
|
|
• germ cell depletion
|
|
|
• the caudal epididymis contains few spermatozoa
|
|
|
• mature spermatids are retained within the seminiferous epithelium
|
|
|
• at 7 weeks and 12 months of age
|
|
|
• testicular degeneration
|
|
|
• sire smaller litters when crossed to wild-type females
|
|
|
• sire fewer and smaller litters when crossed to wild-type females
|
|
|
• at 7 weeks and 12 months of age
|
|
|
• testicular degeneration
|
|
|
• spermatids fail to align at the luminal side of the seminiferous tubules at stage VII of the epithelial cycle
|
|
|
• germ cell depletion
|
|
|
• the caudal epididymis contains few spermatozoa
|
|
|
• decrease in the number of mature spermatids
|
|
|
• mature spermatids are retained within the seminiferous epithelium
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• testes morphology is indistinguishable from controls at 7 weeks of age
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 09/30/2025 MGI 6.24 |
|
|
|
||
