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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trim28tm1.1Ipc
targeted mutation 1.1, Pierre Chambon
MGI:1928907
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tg(Nr5a1-cre)2Klp/0
Trim28tm1.1Ics/Trim28tm1.1Ipc 		involves: 129S * 129S2/SvPas * C57BL/6J * DBA/2J MGI:7471248
cn2
 		Tg(Nr5a1-cre)2Klp/0
Trim28tm1.1Ipc/Trim28tm1.1Ipc 		involves: 129S * 129S2/SvPas * C57BL/6J * DBA/2J MGI:7471250
cn3
 		Trim28tm1.1Ipc/Trim28tm1.2Ipc
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129S2/SvPas * C57BL/6 * CBA MGI:5620619
cn4
 		Trim28tm1Fca/Trim28tm1.1Ipc
Plekha5Tg(AMH-cre)1Flor/Plekha5+ 		involves: 129S2/SvPas * C57BL/6 * SJL MGI:4948087
cn5
 		Trim28tm1.1Ipc/Trim28tm1.1Ipc
Plekha5Tg(AMH-cre)1Flor/Plekha5+ 		involves: 129S2/SvPas * C57BL/6 * SJL MGI:4948089


Genotype
MGI:7471248
cn1
Allelic
Composition		 Tg(Nr5a1-cre)2Klp/0
Trim28tm1.1Ics/Trim28tm1.1Ipc
Genetic
Background		 involves: 129S * 129S2/SvPas * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nr5a1-cre)2Klp mutation (1 available)
Trim28tm1.1Ics mutation (0 available); any Trim28 mutation (33 available)
Trim28tm1.1Ipc mutation (1 available); any Trim28 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal ovarian follicle morphology ( J:327192 )
• follicles organized into pseudo-tubular structures (masculinization: transdifferentiation of granulosa cells into Sertoli cells) at age 8 weeks

reproductive system
abnormal ovarian follicle morphology ( J:327192 )
• follicles organized into pseudo-tubular structures (masculinization: transdifferentiation of granulosa cells into Sertoli cells) at age 8 weeks




Genotype
MGI:7471250
cn2
Allelic
Composition		 Tg(Nr5a1-cre)2Klp/0
Trim28tm1.1Ipc/Trim28tm1.1Ipc
Genetic
Background		 involves: 129S * 129S2/SvPas * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nr5a1-cre)2Klp mutation (1 available)
Trim28tm1.1Ipc mutation (1 available); any Trim28 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal ovarian follicle morphology ( J:327192 )
• medullar follicles organized into pseudo-tubular structures (masculinization: transdifferentiation of granulosa cells into Sertoli cells) at age 8 weeks
• remodeling (masculinization) of cortical follicles started by age 8 weeks, though follicles still organized
• all follicles masculinized at age 4 months

endocrine/exocrine glands
abnormal ovarian follicle morphology ( J:327192 )
• medullar follicles organized into pseudo-tubular structures (masculinization: transdifferentiation of granulosa cells into Sertoli cells) at age 8 weeks
• remodeling (masculinization) of cortical follicles started by age 8 weeks, though follicles still organized
• all follicles masculinized at age 4 months

cellular
cellular phenotype ( J:327192 )
N
• normal apoptosis in ovaries at ages P20 and 8 weeks




Genotype
MGI:5620619
cn3
Allelic
Composition		 Trim28tm1.1Ipc/Trim28tm1.2Ipc
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (42 available)
Trim28tm1.1Ipc mutation (1 available); any Trim28 mutation (33 available)
Trim28tm1.2Ipc mutation (0 available); any Trim28 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryo phenotype ( J:178936 )
N
• embryos no normal yolk sac protrusions or trophoblast malformations
abnormal lateral plate mesoderm morphology ( J:178936 )
• shorter and wider than in control mice

nervous system

digestive/alimentary system
abnormal digestive system development ( J:178936 )
• failure of gut closure

cardiovascular system




Genotype
MGI:4948087
cn4
Allelic
Composition		 Trim28tm1Fca/Trim28tm1.1Ipc
Plekha5Tg(AMH-cre)1Flor/Plekha5+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plekha5Tg(AMH-cre)1Flor mutation (1 available); any Plekha5 mutation (109 available)
Trim28tm1.1Ipc mutation (1 available); any Trim28 mutation (33 available)
Trim28tm1Fca mutation (0 available); any Trim28 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:170392 )
N
• testes morphology is indistinguishable from controls at 7 weeks of age




Genotype
MGI:4948089
cn5
Allelic
Composition		 Trim28tm1.1Ipc/Trim28tm1.1Ipc
Plekha5Tg(AMH-cre)1Flor/Plekha5+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plekha5Tg(AMH-cre)1Flor mutation (1 available); any Plekha5 mutation (109 available)
Trim28tm1.1Ipc mutation (1 available); any Trim28 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:170392 )
N
• no defects are detected in Sertoli cell or spermatogonia proliferation at P5
abnormal spermatid morphology ( J:170392 )
• decrease in the number of mature spermatids
• spermatids fail to align at the luminal side of the seminiferous tubules at stage VII of the epithelial cycle
decreased male germ cell number ( J:170392 )
• germ cell depletion
oligozoospermia ( J:170392 )
• the caudal epididymis contains few spermatozoa
decreased testis weight ( J:170392 )
• at 7 weeks and 12 months of age
testis degeneration ( J:170392 )
• testicular degeneration
abnormal spermiation ( J:170392 )
• mature spermatids are retained within the seminiferous epithelium
decreased litter size ( J:170392 )
• sire smaller litters when crossed to wild-type females
reduced male fertility ( J:170392 )
• sire fewer and smaller litters when crossed to wild-type females

endocrine/exocrine glands
decreased testis weight ( J:170392 )
• at 7 weeks and 12 months of age
testis degeneration ( J:170392 )
• testicular degeneration

cellular
abnormal spermatid morphology ( J:170392 )
• decrease in the number of mature spermatids
• spermatids fail to align at the luminal side of the seminiferous tubules at stage VII of the epithelial cycle
decreased male germ cell number ( J:170392 )
• germ cell depletion
oligozoospermia ( J:170392 )
• the caudal epididymis contains few spermatozoa




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory