All Phenotypes Phox2b<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Phox2b⁺
wild type
MGI:1926868

Summary

16 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Phox2b^tm1.1Heno/Phox2b⁺	either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * DBA/2)	MGI:5451106
ht2	Phox2b^tm2.1Heno/Phox2b⁺	either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * DBA/2)	MGI:5451107
ht3	Phox2b^em3(cre)Heno/Phox2b⁺	involves: 129 * C57BL/6 * C57BL/6N * DBA	MGI:7736348
ht4	Phox2b^tm2Jbr/Phox2b⁺	involves: 129S2/SvPas	MGI:4418308
ht5	Phox2b^tm2Jbr/Phox2b⁺	involves: 129S2/SvPas * C57BL/6	MGI:3797591
ht6	Phox2b^Dilp1/Phox2b⁺	involves: BALB/cAnN * C3H/HeN	MGI:2686835
ht7	Phox2b^tm1Jbr/Phox2b⁺	Not Specified	MGI:2171201
cn8	Phox2b^tm1Rth/Phox2b⁺ Hprt1^{tm1(CAG-cre)Mnn}/?	involves: 129 * 129S1/Sv * C57BL/6	MGI:7397263
cn9	Pcgf1^tm1.1Hko/Pcgf1^tm1.1Hko Phox2b^em3(cre)Heno/Phox2b⁺	involves: 129 * C57BL/6 * C57BL/6N * DBA	MGI:7736341
cn10	Phox2b^tm1Rth/Phox2b⁺ Tg(Fabp7-cre,-lacZ)3Gtm/0	involves: 129 * C57BL/6 * CBA	MGI:7397265
cn11	Phox2b^tm4Jbr/Phox2b⁺ Tg(Pgk1-cre)1Lni/0	involves: 129S2/SvPas * BALB/c * C57BL/6	MGI:4418305
cn12	Phox2b^tm4Jbr/Phox2b⁺ Tg(Pgk1-cre)1Lni/0	involves: 129S2/SvPas * BALB/c * C57BL/6 * DBA/2	MGI:5293365
cn13	Phox2b^tm4Jbr/Phox2b⁺ Tg(Pou3f4-cre)32Cren/0	involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2	MGI:5293366
cn14	Egr2^tm2(cre)Pch/Egr2⁺ Phox2b^tm4Jbr/Phox2b⁺	involves: 129S2/SvPas * C57BL/6 * DBA/2	MGI:5293367
cx15	Kcnk5^{Gt(KST024)Byg}/Kcnk5⁺ Phox2b^tm2Jbr/Phox2b⁺	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:4437575
cx16	Nkx6-2^tm1Ercs/Nkx6-2⁺ Phox2b^{tm1(Phox2a)Mist}/Phox2b⁺	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:3762503

Allelic Composition	Phox2b^tm1.1Heno/Phox2b⁺
Genetic Background	either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * DBA/2)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2b^tm1.1Heno mutation (0 available); any Phox2b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Neurocristopathy in Phox2b^tm1.1Heno/Phox2b⁺ and Phox2b^tm2.1Heno/Phox2b⁺ mice

mortality/aging

neonatal lethality, complete penetrance ( J:190742 )

• mice die soon after birth

nervous system

abnormal glial cell morphology ( J:190742 )

• mice exhibit unbalanced neuroglial differentiation in sympathetic ganglia compared with wild-type mice

impaired neuron differentiation ( J:190742 )

• in nascent chain ganglia

decreased enteric neural crest cell number ( J:190742 )

• fewer enteric neural crest cells in the gut with an increase in undifferentiated cells

abnormal enteric ganglia morphology ( J:190742 )

• fewer in the colon due to delayed gut colonization by enteric neural crest cells

abnormal sympathetic ganglion morphology ( J:190742 )

• smaller with thinner nerve fibers

• occasional aberrant location in the sympathetic chain

• less severe than in Phox2b^tm2.1Heno heterozygotes

• sympathetic ganglia are reduced in size because of impaired commitment, proliferation and differentiation of neuronal progenitors

abnormal retrotrapezoid nucleus morphology ( J:190742 )

• absent

small facial motor nucleus ( J:190742 )

decreased neuronal precursor cell number ( J:190742 )

• with an increase in undifferentiated cells

abnormal vagus ganglion morphology ( J:190742 )

• reduced dorsal motor nucleus of the vagus

abnormal neuron physiology ( J:190742 )

• autonomic neural progenitors from dissociated sympathetic ganglion cells exhibit impaired self-renewal and proliferation compared with wild-type cells

abnormal neuronal precursor proliferation ( J:190742 )

• impaired in sympathetic ganglia

respiratory system

abnormal respiratory function ( J:190742 )

• mice delivered by Caesarian do not breathe spontaneously

• however, breathing could be evoked by skin stimulation

homeostasis/metabolism

cyanosis ( J:190742 )

cellular

abnormal glial cell morphology ( J:190742 )

• mice exhibit unbalanced neuroglial differentiation in sympathetic ganglia compared with wild-type mice

impaired neuron differentiation ( J:190742 )

• in nascent chain ganglia

abnormal enteric neural crest cell migration ( J:190742 )

• at E12, invasion of ENCCs in the hindgut mesenchyme is retarded

decreased enteric neural crest cell proliferation ( J:190742 )

• compromised enteric neural crest cells proliferation in the gut at E10

abnormal neuronal precursor proliferation ( J:190742 )

• impaired in sympathetic ganglia

embryo

abnormal enteric neural crest cell migration ( J:190742 )

• at E12, invasion of ENCCs in the hindgut mesenchyme is retarded

decreased enteric neural crest cell proliferation ( J:190742 )

• compromised enteric neural crest cells proliferation in the gut at E10

decreased enteric neural crest cell number ( J:190742 )

• fewer enteric neural crest cells in the gut with an increase in undifferentiated cells

Allelic Composition	Phox2b^tm2.1Heno/Phox2b⁺
Genetic Background	either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * DBA/2)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2b^tm2.1Heno mutation (0 available); any Phox2b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Neurocristopathy in Phox2b^tm1.1Heno/Phox2b⁺ and Phox2b^tm2.1Heno/Phox2b⁺ mice

mortality/aging

neonatal lethality, complete penetrance ( J:190742 )

• mice die soon after birth

nervous system

abnormal glial cell morphology ( J:190742 )

• mice exhibit unbalanced neuroglial differentiation in sympathetic ganglia compared with wild-type mice

impaired neuron differentiation ( J:190742 )

• in nascent chain ganglia

decreased enteric neural crest cell number ( J:190742 )

• fewer enteric neural crest cells in the gut with an increase in undifferentiated cells

abnormal enteric ganglia morphology ( J:190742 )

• absent in the colon due to delayed gut colonization by enteric neural crest cells

abnormal sympathetic ganglion morphology ( J:190742 )

• smaller with thinner nerve fibers

• occasional aberrant location in the sympathetic chain

• more severe than in Phox2b^tm1.1Heno heterozygotes

• sympathetic ganglia are reduced in size because of impaired commitment, proliferation and differentiation of neuronal progenitors

abnormal retrotrapezoid nucleus morphology ( J:190742 )

• absent

decreased neuronal precursor cell number ( J:190742 )

• with an increase in undifferentiated cells

abnormal neuron physiology ( J:190742 )

• autonomic neural progenitors from dissociated sympathetic ganglion cells exhibit impaired self-renewal and proliferation compared with wild-type cells

abnormal neuronal precursor proliferation ( J:190742 )

• impaired in sympathetic ganglia

respiratory system

abnormal respiratory function ( J:190742 )

• mice delivered by Caesarian do not breathe spontaneously

• however, breathing could be evoked by skin stimulation

cellular

abnormal glial cell morphology ( J:190742 )

• mice exhibit unbalanced neuroglial differentiation in sympathetic ganglia compared with wild-type mice

impaired neuron differentiation ( J:190742 )

• in nascent chain ganglia

abnormal enteric neural crest cell migration ( J:190742 )

• severe delay in gut colonization by mutant ENCCs at E12.0

decreased enteric neural crest cell proliferation ( J:190742 )

• compromised enteric neural crest cells proliferation in the gut at E10

abnormal neuronal precursor proliferation ( J:190742 )

• impaired in sympathetic ganglia

homeostasis/metabolism

cyanosis ( J:190742 )

embryo

abnormal enteric neural crest cell migration ( J:190742 )

• severe delay in gut colonization by mutant ENCCs at E12.0

decreased enteric neural crest cell proliferation ( J:190742 )

• compromised enteric neural crest cells proliferation in the gut at E10

decreased enteric neural crest cell number ( J:190742 )

• fewer enteric neural crest cells in the gut with an increase in undifferentiated cells

Allelic Composition	Phox2b^em3(cre)Heno/Phox2b⁺
Genetic Background	involves: 129 * C57BL/6 * C57BL/6N * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2b^em3(cre)Heno mutation (0 available); any Phox2b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

postnatal growth retardation ( J:344865 )

• slight growth retardation at 3 and 8 weeks of age

Allelic Composition	Phox2b^tm2Jbr/Phox2b⁺
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2b^tm2Jbr mutation (0 available); any Phox2b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron physiology ( J:155885 )

• the parafacial area e-pF oscillator exhibits only occasional motor activity bursts with reduced frequency compared to in wild-type mice

• rhythmic phrenic discharges are less frequent than in wild-type mice

• mice fail to exhibit an accelerated respiratory-like rhythm phrenic discharge in response to low pH challenge unlike similarly treated wild-type mice

• however, mice exhibit functional pre-Botzinger complex

Allelic Composition	Phox2b^tm2Jbr/Phox2b⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2b^tm2Jbr mutation (0 available); any Phox2b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:131365 )

• die within the first hours after birth from respiratory failure

homeostasis/metabolism

cyanosis ( J:131365 )

respiratory system

abnormal respiration ( J:131365 )

abnormal lung volume ( J:131365 )

• mean respiratory minute volume (VE) during apnea-free periods of eupnoeic pups is depressed in mutants

abnormal breathing pattern ( J:131365 )

• mutants exhibit gasping behavior and breathing irregularity is significantly greater in mutants

• plethysmographic recordings immediately after delivery show a range of phenotypes; 3 of 18 mutants ventilate only by intermittent gasping, the remaining breathe rhythmically but at a slower rate or show chaotic breathing that is interrupted by periods of apnea

apnea ( J:131365 )

• apneic episodes are more frequent and last longer in mutants than in wild-type, resulting in a 6.5-fold higher total apnea duration

hypoventilation ( J:131365 )

• baseline ventilation in air is depressed in mutants

• mutants do not increase their ventilation in response to hypercapnia (elevated pCO2)

respiratory failure ( J:131365 )

• die within the first hours after birth from respiratory failure

nervous system

abnormal brain interneuron morphology ( J:131365 )

• loss of a set of parafacial interneurons in the RTN/pFRG region

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital central hypoventilation syndrome		DOID:0060731	OMIM:209880	J:131365

Allelic Composition	Phox2b^Dilp1/Phox2b⁺
Genetic Background	involves: BALB/cAnN * C3H/HeN

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2b^Dilp1 mutation (0 available); any Phox2b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:75964 )

• abnormal Mendelian ratios suggested that some heterozygous mice die before weaning

vision/eye

impaired pupillary reflex ( J:91199 )

• exhibit no pupillary response to light

• pupils fail to constrict in response to the parasympathetic agonist, carbachol

abnormal eye morphology ( J:75964 )

mydriasis ( J:75964 , J:91199 )

behavior/neurological

impaired pupillary reflex ( J:91199 )

• exhibit no pupillary response to light

• pupils fail to constrict in response to the parasympathetic agonist, carbachol

nervous system

abnormal ciliary ganglion morphology ( J:91199 )

• exhibit severe atrophy of the ciliary ganglia at E13.5

• however, the superior cervical ganglion is normal

Allelic Composition	Phox2b^tm1Jbr/Phox2b⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2b^tm1Jbr mutation (0 available); any Phox2b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

impaired pupillary reflex ( J:91199 )

• exhibit no pupillary response to light

• pupils fail to constrict in response to the parasympathetic agonist, carbachol

mydriasis ( J:91199 )

• exhibit bilateral dilated pupils

behavior/neurological

impaired pupillary reflex ( J:91199 )

• exhibit no pupillary response to light

• pupils fail to constrict in response to the parasympathetic agonist, carbachol

nervous system

abnormal ciliary ganglion morphology ( J:91199 )

• exhibit severe atrophy of the ciliary ganglia at E13.5

• however, the superior cervical ganglion is normal

respiratory system

abnormal pulmonary ventilation ( J:86516 )

• exhibit an altered response to hypoxia and hypercapnia at birth; hypoxia results in a similar increase in ventilation as in wild-type but the total duration of post hypnoxic apneas is longer

decreased pulmonary ventilation ( J:86516 )

• ventilatory response to hypercapnia is markedly lower than in wild-type at P2 and P6, but not at P10

Allelic Composition	Phox2b^tm1Rth/Phox2b⁺ Hprt1^{tm1(CAG-cre)Mnn}/?
Genetic Background	involves: 129 * 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm1(CAG-cre)Mnn} mutation (1 available); any Hprt1 mutation (1280 available)
Phox2b^tm1Rth mutation (1 available); any Phox2b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:331513 )

• perinatal lethality, with death before P1

respiratory system

respiratory failure ( J:331513 )

• harvest just prior to birth at E18.5, shows that only 33% of mutants take one spontaneous breath and no mutants show further spontaneous respiratory effort, become cyanotic, and all die within minutes of delivery

nervous system

abnormal trigeminal V mesencephalic nucleus morphology ( J:331513 )

• loss of TH neurons in the mesencephalic trigeminal nucleus nuclei

abnormal locus ceruleus morphology ( J:331513 )

• the locus coeruleus is abnormal and fails to express tyrosine hydroxylase (TH), indicating absence of TH neurons; sparse and small neuronal cell bodies are seen suggesting cellular loss/attrition of these neurons

abnormal innervation ( J:331513 )

• abnormalities in noradrenergic circuits, including caudal hindbrain nuclei A1/C2 and the forebrain projections of locus coeruleus to hypothalamus

abnormal neuron morphology ( J:331513 )

• loss of TH neurons in the locus coereleus, the dorsal motor nucleus of the vagus, and mesencephalic trigeminal nucleus nuclei

• however, neuronal precursors of the dorsal motor nucleus of the vagus (DMNV) are detectable at E13.5 indicating that progenitor specification occurs

• however, serotonergic neurons that express tryptophan hydroxylase and 5HT appear normal and no gross abnormalities in forebrain are seen

abnormal facial nerve morphology ( J:331513 )

• abnormal formation of the seventh cranial nerve (CNVII, facial nucleus) in the embryonic brainstem is due to failure of precursor migration

abnormal vagus nerve morphology ( J:331513 )

• loss of TH neurons in the dorsal motor nucleus of the vagus

abnormal nervous system electrophysiology ( J:331513 )

• electrophysiological recordings from E18.5 ex vivo brain stem shows depression of endogenous respiratory motor root output under baseline conditions and in response to the excitatory neuropeptide, substance P

homeostasis/metabolism

cyanosis ( J:331513 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital central hypoventilation syndrome		DOID:0060731	OMIM:209880	J:331513

Allelic Composition	Pcgf1^tm1.1Hko/Pcgf1^tm1.1Hko Phox2b^em3(cre)Heno/Phox2b⁺
Genetic Background	involves: 129 * C57BL/6 * C57BL/6N * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcgf1^tm1.1Hko mutation (1 available); any Pcgf1 mutation (20 available)
Phox2b^em3(cre)Heno mutation (0 available); any Phox2b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:344865 )

• only half of mutants survive to adulthood

growth/size/body

decreased body size ( J:344865 )

• at 3 weeks of age

postnatal growth retardation ( J:344865 )

• at 3 weeks of age but catch up to controls (mice carrying just the recombinase allele) by 8 weeks of age

digestive/alimentary system

abnormal feces composition ( J:344865 )

• lighter and drier feces

decreased feces water content ( J:344865 )

abnormal colon morphology ( J:344865 )

• decrease in the number of the somatostatin-expressing neurons in the proximal colon

• increase in the number of calbindin-expressing neurons in the proximal colon

abnormal ileum morphology ( J:344865 )

• decrease in the number of the somatostatin-expressing neurons in the ileum

abnormal jejunum morphology ( J:344865 )

• decrease in the number of the somatostatin-expressing neurons in the jejunum

abnormal intestinal transit time ( J:344865 )

• increased total gastrointestinal transit time

nervous system

decreased neuron number ( J:344865 )

• decrease in the number of the somatostatin-expressing neurons in the ileum, jejunum, and proximal colon

increased neuron number ( J:344865 )

• increase in the number of calbindin-expressing neurons in the proximal colon

Allelic Composition	Phox2b^tm1Rth/Phox2b⁺ Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background	involves: 129 * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2b^tm1Rth mutation (1 available); any Phox2b mutation (23 available)
Tg(Fabp7-cre,-lacZ)3Gtm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal suckling behavior ( J:331513 )

• pups fail to nurse and gain adequate body weight

respiratory system

decreased pulmonary respiratory rate ( J:331513 )

• mice show spontaneous/continuous breathing, albeit at a slightly reduced frequency, and do not exhibit cyanosis

nervous system

nervous system phenotype ( J:331513 )

N	• mice show normal locus coeruleus tyrosine hydroxylase + populations and normal number of serotonergic neurons expressing tryptophan hydroxylase

abnormal retrotrapezoid nucleus morphology ( J:331513 )

• brainstems show loss of the retrotrapezoid nucleus

abnormal facial nerve morphology ( J:331513 )

• brainstems show loss of the seventh cranial nerve (CNVII) nuclei

• abnormal formation of CNVII in the embryonic brainstem is due to failure of precursor migration

Allelic Composition	Phox2b^tm4Jbr/Phox2b⁺ Tg(Pgk1-cre)1Lni/0
Genetic Background	involves: 129S2/SvPas * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2b^tm4Jbr mutation (1 available); any Phox2b mutation (23 available)
Tg(Pgk1-cre)1Lni mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal respiration ( J:155885 )

• mice are indistinguishable from Phox2b^tm2Jbr heterozygotes

Allelic Composition	Phox2b^tm4Jbr/Phox2b⁺ Tg(Pgk1-cre)1Lni/0
Genetic Background	involves: 129S2/SvPas * BALB/c * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2b^tm4Jbr mutation (1 available); any Phox2b mutation (23 available)
Tg(Pgk1-cre)1Lni mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:176573 )

nervous system

abnormal retrotrapezoid nucleus morphology ( J:176573 )

• massive depletion of retrotrapezoid nucleus neurons

Allelic Composition	Phox2b^tm4Jbr/Phox2b⁺ Tg(Pou3f4-cre)32Cren/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2b^tm4Jbr mutation (1 available); any Phox2b mutation (23 available)
Tg(Pou3f4-cre)32Cren mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:176573 )

Allelic Composition	Egr2^tm2(cre)Pch/Egr2⁺ Phox2b^tm4Jbr/Phox2b⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr2^tm2(cre)Pch mutation (2 available); any Egr2 mutation (32 available)
Phox2b^tm4Jbr mutation (1 available); any Phox2b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:176573 )

N	• the great majority of mice survive to adulthood

nervous system

abnormal retrotrapezoid nucleus morphology ( J:176573 )

• massive depletion of retrotrapezoid nucleus neurons at P9

abnormal autonomic nervous system physiology ( J:176573 )

• frequency of rhythmic phrenic discharges is reduced and does not respond to acidification

respiratory system

abnormal respiratory function ( J:176573 )

• hypoxic response is more vigorous (increase in ventilation is more pronounced and lasts longer) compared to controls

• exposure to pure O2 triggers periodic breathing in mutants but not in controls

decreased pulmonary ventilation ( J:176573 )

• in normoxia mean ventilation is reduced due to longer breath duration

• complete absence of normal response to hypercapnia at P2 and P9

• at 3 weeks and 4 months of age mice display a reduced increase in ventilation in response to hypercapnia

homeostasis/metabolism

alkalemia ( J:176573 )

• slight but statistically significant increase in pH

Allelic Composition	Kcnk5^{Gt(KST024)Byg}/Kcnk5⁺ Phox2b^tm2Jbr/Phox2b⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnk5^{Gt(KST024)Byg} mutation (0 available); any Kcnk5 mutation (62 available)
Phox2b^tm2Jbr mutation (0 available); any Phox2b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal retrotrapezoid nucleus morphology ( J:157526 )

• retrotrapezoid nucleus neurons are absent

Allelic Composition	Nkx6-2^tm1Ercs/Nkx6-2⁺ Phox2b^{tm1(Phox2a)Mist}/Phox2b⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx6-2^tm1Ercs mutation (1 available); any Nkx6-2 mutation (16 available)
Phox2b^{tm1(Phox2a)Mist} mutation (1 available); any Phox2b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon extension ( J:126634 )

• axonal tracts are thinner than in wild-type mice, especially for the tenth cranial nerve

abnormal vagus ganglion morphology ( J:126634 )

• axonal tracts are thinner than in wild-type mice, especially for the tenth cranial nerve

cellular

abnormal axon extension ( J:126634 )

• axonal tracts are thinner than in wild-type mice, especially for the tenth cranial nerve

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