Nkx6-2^tm1Ercs
Targeted Allele Detail

Summary

• Symbol: Nkx6-2^tm1Ercs
• Name: NK6 homeobox 2; targeted mutation 1, Johan Ericson
• MGI ID: MGI:2651850
• Synonyms: Nkx6.2^tlz
• Gene: Nkx6-2 Location: Chr7:139159292-139162713 bp, - strand Genetic Position: Chr7, 84.57 cM
• Alliance: Nkx6-2^tm1Ercs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71607
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced with a cassette containing tau-lacZ and neo. Beta-galactosidase is expressed from this allele under the control of the endogenous promoter. (J:71607)

Expression

In Mice Carrying this Mutation:

27 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nkx6-2 Mutation: 16 strains or lines available

References

• Original: J:71607 Vallstedt A, et al., Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification. Neuron. 2001 Sep 13;31(5):743-55
• All: 12 reference(s)