Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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homeostasis/metabolism
vision/eye
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• develop extensive crusts around the eyes
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integument
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• hair loss becomes more severe upon aging, such that older mutants appear almost hairless
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endocrine/exocrine glands
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation
(19 available);
any
Ldlr mutation
(76 available)
Tg(APOC1)1Lmh mutation
(0 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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growth/size/body
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• mutants appear smaller, however weight at 2.5 months of age is similar to wild-type
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homeostasis/metabolism
adipose tissue
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• skin lacks subcutaneous adipose tissue
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• small abdominal fat pads
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cardiovascular system
hematopoietic system
immune system
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• some mutants develop mild folliculitis
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• at older ages, lesions develop into severe dermatitis, with a moderate epidermal hyperplasia with hyper- and parakeratosis
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liver/biliary system
vision/eye
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• develop extensive crusts around the eyes
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• meibomian glands lack the typical foamy appearance
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integument
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• skin lacks subcutaneous adipose tissue
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• epidermis of older mice is necrotic with extensive infiltration of inflammatory cells
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• meibomian glands lack the typical foamy appearance
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• the cytoplasm of the atrophic sebaceous glands loses its foamy appearance
• the outer surface of the eyelids shows sebaceous gland atrophy
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• some mutants develop mild folliculitis
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• at older ages, lesions develop into severe dermatitis, with a moderate epidermal hyperplasia with hyper- and parakeratosis
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• hair loss becomes more severe upon aging, such that older mutants appear almost hairless
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• develops in older mutants
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• mutants exhibit skin lesions that vary from a mild folliculitis to a mild mixed cellular infiltration in the dermis
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endocrine/exocrine glands
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• meibomian glands lack the typical foamy appearance
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• the cytoplasm of the atrophic sebaceous glands loses its foamy appearance
• the outer surface of the eyelids shows sebaceous gland atrophy
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cellular
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• epidermis of older mice is necrotic with extensive infiltration of inflammatory cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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integument
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• 90% of mice show mild-to-moderate spongiosis from 6 weeks onward
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• 12 week old mutants exhibit a 4-fold increase in transepidermal water loss indicating that skin barrier function is disturbed; an increase is already seen at 3 weeks
• treatment with 20% petrolatum in cetomacrogolus cream for 3 weeks diminishes loss of barrier function
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• eosinophil, mast cell, CD4+ T cell, and macrophage infiltration into the skin by 6 weeks of age
• treatment with a corticosteroid cream for 3 weeks diminishes the number of granulocytes, macrophages and CD4+ t cells, but had no effect on mast cells
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• mice develop signs of atopic dermatitis, comprising scaling, lichenification, papules and mild-to-severe excoriations from an age of 6 weeks
• dermatitis is evident in the upper dorsal skin and with age, the head and eyelids become affected
• treatment with 20% petrolatum in cetomacrogolus cream for 3 weeks decreases severity of dermatitis
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• epidermal hyperplasia
• treatment with a corticosteroid cream for 3 weeks inhibits epidermal hyperplasia but results in thinning of the epidermis
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• frequency of scratching and duration at 9 weeks of age is increased and increases further with age
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immune system
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• mast cells show degranulation
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• serum IgE levels are increased at 12 weeks of age, but not at 8 weeks of age
• from 12 weeks of age, mast cells in the dermis become IgE-positive
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• eosinophil, mast cell, CD4+ T cell, and macrophage infiltration into the skin by 6 weeks of age
• treatment with a corticosteroid cream for 3 weeks diminishes the number of granulocytes, macrophages and CD4+ t cells, but had no effect on mast cells
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• mice develop signs of atopic dermatitis, comprising scaling, lichenification, papules and mild-to-severe excoriations from an age of 6 weeks
• dermatitis is evident in the upper dorsal skin and with age, the head and eyelids become affected
• treatment with 20% petrolatum in cetomacrogolus cream for 3 weeks decreases severity of dermatitis
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behavior/neurological
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• frequency of scratching and duration at 9 weeks of age is increased and increases further with age
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hematopoietic system
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• mast cells show degranulation
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• serum IgE levels are increased at 12 weeks of age, but not at 8 weeks of age
• from 12 weeks of age, mast cells in the dermis become IgE-positive
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homeostasis/metabolism
cellular
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• mast cells show degranulation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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homeostasis/metabolism
integument
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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Analysis Tools