All Phenotypes Lhx1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lhx1⁺
wild type
MGI:1857849

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Lhx1^{tm1a(EUCOMM)Wtsi}/Lhx1⁺	C57BL/6N-Lhx1^{tm1a(EUCOMM)Wtsi}/Ics	MGI:5782121
ht2	Lhx1^tm1Bhr/Lhx1⁺	involves: 129S7/SvEvBrd * C3H/He * C57BL/6 * ICR	MGI:3663941
cn3	Lhx1^tm1Tmj/Lhx1⁺ Ret^tm1Kln/Ret^tm1Kln Tg(Nes-cre)1Kln/0	involves: 129/Sv * BALB/c * C57BL/6 * CBA/J * SJL	MGI:3662908
cx4	Lhx1^tm1Bhr/Lhx1⁺ Ssbp3^{Tg(SOD1)1Hssk}/Ssbp3⁺	involves: 129S7/SvEvBrd * C3H/He * C57BL/6 * ICR	MGI:3663940
cx5	Cer1^tm1Bhr/Cer1^tm1Bhr Lhx1^tm1Bhr/Lhx1⁺	involves: 129S7/SvEvBrd * C57BL/6	MGI:3723147
cx6	Lhx1^tm1Bhr/Lhx1⁺ Pgap1^oto/Pgap1^oto	involves: 129S7/SvEvBrd * C57BL/6J * STOCK In(1)1Rk/J	MGI:4355069
cx7	Lhx1^tm1Bhr/Lhx1⁺ Pgap1^oto/Pgap1⁺	involves: 129S7/SvEvBrd * C57BL/6J * STOCK In(1)1Rk/J	MGI:4355067
cx8	Lhx1^tm1Tmj/Lhx1⁺ Ret^tm1.1Kln/Ret^tm1.1Kln	involves: 129/Sv * BALB/c * C57BL/6 * CBA/J	MGI:3662907

Allelic Composition	Lhx1^{tm1a(EUCOMM)Wtsi}/Lhx1⁺
Genetic Background	C57BL/6N-Lhx1^{tm1a(EUCOMM)Wtsi}/Ics
Cell Lines	EPD0243_4_E03

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx1^{tm1a(EUCOMM)Wtsi} mutation (0 available); any Lhx1 mutation (21 available)

Data Sources

IMPC Data for Lhx1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating alkaline phosphatase level ( J:165965 )

IMPC - ICS

Allelic Composition	Lhx1^tm1Bhr/Lhx1⁺
Genetic Background	involves: 129S7/SvEvBrd * C3H/He * C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx1^tm1Bhr mutation (2 available); any Lhx1 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:98485 )

• single heterozygotes from intercrosses with Ssbp3^{Tg(SOD1)1Hssk}/+ mice appear normal at E9.0-9.5

Allelic Composition	Lhx1^tm1Tmj/Lhx1⁺ Ret^tm1Kln/Ret^tm1Kln Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129/Sv * BALB/c * C57BL/6 * CBA/J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx1^tm1Tmj mutation (0 available); any Lhx1 mutation (21 available)
Ret^tm1Kln mutation (2 available); any Ret mutation (52 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon guidance ( J:110955 )

• peroneal nerve at E12.5 is rerouted to the path of the tibial nerve

• trajectory of small branch emerging from PN in mutants does not match stereotyped path of dorsal growing PN axons in controls

• phenotype of mice is more severe than in wild-type Lhx1 background

cellular

abnormal axon guidance ( J:110955 )

• peroneal nerve at E12.5 is rerouted to the path of the tibial nerve

• trajectory of small branch emerging from PN in mutants does not match stereotyped path of dorsal growing PN axons in controls

• phenotype of mice is more severe than in wild-type Lhx1 background

Allelic Composition	Lhx1^tm1Bhr/Lhx1⁺ Ssbp3^{Tg(SOD1)1Hssk}/Ssbp3⁺
Genetic Background	involves: 129S7/SvEvBrd * C3H/He * C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx1^tm1Bhr mutation (2 available); any Lhx1 mutation (21 available)
Ssbp3^{Tg(SOD1)1Hssk} mutation (0 available); any Ssbp3 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

embryonic growth retardation ( J:98485 )

• some double heterozygotes display severe growth retardation and microcephaly

microcephaly ( J:98485 )

• double heterozygotes display variable degrees of microcephaly; some embryos appear normal, others display microcephaly while another subset show microcephaly and severe growth retardation

embryo

failure of initiation of embryo turning ( J:98485 )

• the most severely affected double heterozygotes fail to undergo embryonic turning

embryonic growth retardation ( J:98485 )

• some double heterozygotes display severe growth retardation and microcephaly

Allelic Composition	Cer1^tm1Bhr/Cer1^tm1Bhr Lhx1^tm1Bhr/Lhx1⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cer1^tm1Bhr mutation (0 available); any Cer1 mutation (12 available)
Lhx1^tm1Bhr mutation (2 available); any Lhx1 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:62080 )

• the expected frequency of mutants are obtain and they appear phenotypically normal

Allelic Composition	Lhx1^tm1Bhr/Lhx1⁺ Pgap1^oto/Pgap1^oto
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * STOCK In(1)1Rk/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx1^tm1Bhr mutation (2 available); any Lhx1 mutation (21 available)
Pgap1^oto mutation (0 available); any Pgap1 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal brain morphology ( J:41878 )

• in severely affected mice, anterior central nervous system defects are more severe than in Pgap1^oto homozygotes

abnormal diencephalon morphology ( J:41878 )

• the anterior-ventral diencephalon is hypoplastic

abnormal telencephalon morphology ( J:41878 )

• reduced in 75% mice at E9.5

Allelic Composition	Lhx1^tm1Bhr/Lhx1⁺ Pgap1^oto/Pgap1⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * STOCK In(1)1Rk/J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal telencephalon morphology ( J:41878 )

• reduced in 15% mice at E8.5 and E9.5

Allelic Composition	Lhx1^tm1Tmj/Lhx1⁺ Ret^tm1.1Kln/Ret^tm1.1Kln
Genetic Background	involves: 129/Sv * BALB/c * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx1^tm1Tmj mutation (0 available); any Lhx1 mutation (21 available)
Ret^tm1.1Kln mutation (0 available); any Ret mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon guidance ( J:110955 )

• peroneal nerve at E12.5 is rerouted to the path of the tibial nerve

• trajectory of small branch emerging from PN in mutants does not match stereotyped path of dorsal growing PN axons in controls

cellular

abnormal axon guidance ( J:110955 )

• peroneal nerve at E12.5 is rerouted to the path of the tibial nerve

• trajectory of small branch emerging from PN in mutants does not match stereotyped path of dorsal growing PN axons in controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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