All Phenotypes Cbfb<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cbfb⁺
wild type
MGI:1857594

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Cbfb^tm1Ppl/Cbfb⁺	either: (involves: 129/Sv * 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)	MGI:3838168
ht2	Cbfb^tm4Ppl/Cbfb⁺	involves: 129S6/SvEvTac * C57BL/6	MGI:4461979
ht3	Cbfb^tm3Ppl/Cbfb⁺	involves: 129S6/SvEvTac * C57BL/6	MGI:4461978
ht4	Cbfb^tm6Ppl/Cbfb⁺	involves: 129S/SvEv * C57BL/6	MGI:6407120
ht5	Cbfb^tm5Ppl/Cbfb⁺	Not Specified	MGI:5470056
cn6	Cbfb^tm1Lhc/Cbfb⁺ Tg(EIIa-cre)C5379Lmgd/0	involves: 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:3615451

Allelic Composition	Cbfb^tm1Ppl/Cbfb⁺
Genetic Background	either: (involves: 129/Sv * 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfb^tm1Ppl mutation (0 available); any Cbfb mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:36594 )

• all embryos normal at E11.5

• lethality between E11.5 and E13.5

cardiovascular system

internal hemorrhage ( J:36594 )

• multiple hemorrhages begin to develop at E12

hemopericardium ( J:36594 )

• sometimes

hemoperitoneum ( J:36594 )

• sometimes

intracranial hemorrhage ( J:36594 )

• hemorrhages mostly in the central nervous system, 100% of E12.5 embryos

• periventricular regions of the striatum, pons, medulla

• intraparenchymal hemorrhage frequent at the ganglia of cranial nerves VII and VIII

brainstem hemorrhage ( J:36594 )

intraventricular hemorrhage ( J:36594 )

• blood often accumulates in the ventricles

spinal hemorrhage ( J:36594 )

cellular

increased apoptosis ( J:36594 )

• observed in areas susceptible to hemorrhage

liver/biliary system

small liver ( J:36594 )

• from E11.5 to E13.5

pale liver ( J:36594 )

• few or no erythropoietic cells

• no megakaryocytes

hematopoietic system

extramedullary hematopoiesis ( J:36594 )

• no definitive hematopoietic cells in the hepatic cords at E11.5-E13.5

• mostly immature yolk sac derived erythrocytes in the circulation at E12.5, about 78%

impaired hematopoiesis ( J:36594 )

• reduced ability of fetal liver and yolk cells to proliferate and differentiate in vitro

nervous system

intracranial hemorrhage ( J:36594 )

• hemorrhages mostly in the central nervous system, 100% of E12.5 embryos

• periventricular regions of the striatum, pons, medulla

• intraparenchymal hemorrhage frequent at the ganglia of cranial nerves VII and VIII

brainstem hemorrhage ( J:36594 )

intraventricular hemorrhage ( J:36594 )

• blood often accumulates in the ventricles

spinal hemorrhage ( J:36594 )

homeostasis/metabolism

hemopericardium ( J:36594 )

• sometimes

Allelic Composition	Cbfb^tm4Ppl/Cbfb⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfb^tm4Ppl mutation (0 available); any Cbfb mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

pale liver ( J:160522 )

• very pale liver

hematopoietic system

abnormal bone marrow cell morphology/development ( J:160522 )

• no hematopoietic progenitors visible in liver sections

absent megakaryocytes ( J:160522 )

• no megakaryocytes in the liver

Allelic Composition	Cbfb^tm3Ppl/Cbfb⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfb^tm3Ppl mutation (0 available); any Cbfb mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:160522 )

• several pups survive to at least E13.5

• one embryo found at E16.5 with no signs of hemorrhage

postnatal lethality, complete penetrance ( J:160522 )

• heterozygotes die by 10-18 days of age

prenatal lethality, incomplete penetrance ( J:160522 )

• most heterozygous pups die before birth, 2 out of 25 pups are born alive

cardiovascular system

internal hemorrhage ( J:160522 )

• E12.5 embryos develop multiple hemorrhages in the central nervous system

liver/biliary system

pale liver ( J:160522 )

• pale liver at E12.5- E13.5

hematopoietic system

hematopoietic system phenotype ( J:160522 )

N	• hematopoietic progenitors clearly visible in liver sections • megakaryocytes found in the liver

decreased hematopoietic stem cell number ( J:160522 )

• reduced in-vitro hematopoietic colony formation

Allelic Composition	Cbfb^tm6Ppl/Cbfb⁺
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfb^tm6Ppl mutation (0 available); any Cbfb mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:252447 )

N	• adult bone marrow cells show no difference from wild-type in lineage differentiation, colony forming ability, cell viability, total cell count and apoptosis

decreased B cell number ( J:252447 )

• decrease in B cells in older mice

increased myeloid cell number ( J:252447 )

• increase in Mac1+Gr1+ myeloid cells in older mice

immune system

decreased B cell number ( J:252447 )

• decrease in B cells in older mice

neoplasm

neoplasm ( J:252447 )

N	• mice do not develop leukemia, even after treatment with ENU to induce additional mutations

Allelic Composition	Cbfb^tm5Ppl/Cbfb⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfb^tm5Ppl mutation (0 available); any Cbfb mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal mononuclear cell differentiation ( J:193140 )

• bone marrow cells from mice treated with ENU produce more granulocyte and macrophage (CFU-GM) colonies compared with wild-type mice

myeloid hyperplasia ( J:193140 )

• some aged mice treated with ENU develop myeloproliferative disease with increased Mac1/Gr1+ cells in the peripheral blood

• increased myelopoiesis in the bone marrow and spleen of some aged mice treated with ENU

• however, cells do not exhibit a blast-like appearance and transplanted cells do not result in abnormal myelopoiesis in recipient mice

neoplasm

neoplasm ( J:193140 )

N	• ENU-treated mice do not develop leukemia

cellular

abnormal mononuclear cell differentiation ( J:193140 )

• bone marrow cells from mice treated with ENU produce more granulocyte and macrophage (CFU-GM) colonies compared with wild-type mice

immune system

abnormal mononuclear cell differentiation ( J:193140 )

• bone marrow cells from mice treated with ENU produce more granulocyte and macrophage (CFU-GM) colonies compared with wild-type mice

myeloid hyperplasia ( J:193140 )

• some aged mice treated with ENU develop myeloproliferative disease with increased Mac1/Gr1+ cells in the peripheral blood

• increased myelopoiesis in the bone marrow and spleen of some aged mice treated with ENU

• however, cells do not exhibit a blast-like appearance and transplanted cells do not result in abnormal myelopoiesis in recipient mice

Allelic Composition	Cbfb^tm1Lhc/Cbfb⁺ Tg(EIIa-cre)C5379Lmgd/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfb^tm1Lhc mutation (0 available); any Cbfb mutation (39 available)
Tg(EIIa-cre)C5379Lmgd mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:105040 )

• embryos die by midgestation

hematopoietic system

impaired hematopoiesis ( J:105040 )

• embryos display hematopoeitic deficiency

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