Cbfb^tm1Lhc
Targeted Allele Detail

Summary

• Symbol: Cbfb^tm1Lhc
• Name: core binding factor beta; targeted mutation 1, Lucio H Castilla
• MGI ID: MGI:3579250
• Synonyms: Cbfb^56M
• Gene: Cbfb Location: Chr8:105897306-105944621 bp, + strand Genetic Position: Chr8, 53.04 cM
• Alliance: Cbfb^tm1Lhc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98443
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: ES cells containing Cbfb^tm1Ppl were targeted a second time to insert a floxed cassette encompassing exons 5 and 6, as well as the bovine growth hormone polyA signal and a PGK-hygro cassette into the Msc1 site in intron 4. This design allows the wild-type Cbfb transcript to be expressed. Cre expression would remove the cassette and restore expression of the knockin allele. (J:105040)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cbfb Mutation: 39 strains or lines available

References

• Original: J:98443 Landrette SF, et al., Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11. Blood. 2005 Apr 1;105(7):2900-7
• All: 19 reference(s)