All Phenotypes Cd40<tm1Kik> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cd40^tm1Kik
targeted mutation 1, Hitoshi Kikutani
MGI:1857457

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd40^tm1Kik/Cd40^tm1Kik	B6.129P2-Cd40^tm1Kik/J	MGI:3035906
hm2	Cd40^tm1Kik/Cd40^tm1Kik	involves: 129P2/OlaHsd	MGI:5013462
hm3	Cd40^tm1Kik/Cd40^tm1Kik	involves: 129P2/OlaHsd * C57BL/6	MGI:3035907
cn4	Cd40^tm1Kik/Cd40⁺ Mir146^tm1.1Lfl/Mir146^tm1.1Lfl Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd * C57BL/6	MGI:6360064
cx5	Cd40^tm1Kik/Cd40^tm1Kik Tg(Tnfsf13b)1Fma/?	B6.Cg-Cd40^tm1Kik Tg(Tnfsf13b)1Fma	MGI:3841106
cx6	Cd40^tm1Kik/Cd40^tm1Kik Traf3ip2^tm1.1Lix/Traf3ip2^tm1.1Lix	involves: 129 * 129P2/OlaHsd * BALB/c	MGI:3511170
cx7	Cd40^tm1Kik/Cd40^tm1Kik Tnfsf11^tm1Pngr/Tnfsf11^tm1Pngr	involves: 129P2/OlaHsd	MGI:5013467
cx8	Bank1^tm1Kuro/Bank1^tm1Kuro Cd40^tm1Kik/Cd40^tm1Kik	involves: 129P2/OlaHsd	MGI:3687154
cx9	Cd40^tm1Kik/Cd40^tm1Kik Tg(Igh-V-CD40lg)#Tsub/0	involves: 129P2/OlaHsd * C57BL/6	MGI:4461234
cx10	Cd40^tm1Kik/Cd40^tm1Kik Ltbr^tm1Mmat/Ltbr^tm1Mmat	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5013463

Allelic Composition	Cd40^tm1Kik/Cd40^tm1Kik
Genetic Background	B6.129P2-Cd40^tm1Kik/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40^tm1Kik mutation (11 available); any Cd40 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:75152 )

N	• normal thrombogenesis in ferric-chloride-induced injury of mesenteric arterioles

decreased platelet aggregation ( J:108988 )

• reduced number of rolling platelets and 50% attenuation in platelet adhesion following 1 hour of middle cerebral artery occlusion and 4 hours of reperfusion

immune system

abnormal dendritic cell physiology ( J:86998 )

• impaired production of IL-12 after Mycobacterium tuberculosis infection and after incubation with Hsp7

• impaired priming of IFN-gamma producing T cells

increased susceptibility to bacterial infection ( J:86998 )

• increased susceptibility to aerosol Mycobacterium tuberculosis infection

• increased bacterial loads in lung and spleen

• 40% of infected mice moribund 3 - 4 weeks postinfection

homeostasis/metabolism

decreased platelet aggregation ( J:108988 )

• reduced number of rolling platelets and 50% attenuation in platelet adhesion following 1 hour of middle cerebral artery occlusion and 4 hours of reperfusion

decreased cerebral infarct size ( J:108988 )

• significantly reduced infarct volumes

nervous system

decreased cerebral infarct size ( J:108988 )

• significantly reduced infarct volumes

skeleton

decreased bone mineral density ( J:145330 )

• significantly reduced

decreased compact bone mass ( J:145330 )

• significantly reduced

decreased trabecular bone mass ( J:145330 )

• significantly reduced

Allelic Composition	Cd40^tm1Kik/Cd40^tm1Kik
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40^tm1Kik mutation (11 available); any Cd40 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:173115 )

N	• mice exhibit well-developed thymic medullas

decreased B cell number ( J:190943 )

• NP-CG immunized mice fail to generate NP-specific IgG1+B cells at day 7

absent germinal center B cells ( J:190943 )

• NP-CG immunized mice fail to generate NP-specific germinal center B cells

hematopoietic system

decreased B cell number ( J:190943 )

• NP-CG immunized mice fail to generate NP-specific IgG1+B cells at day 7

absent germinal center B cells ( J:190943 )

• NP-CG immunized mice fail to generate NP-specific germinal center B cells

Allelic Composition	Cd40^tm1Kik/Cd40^tm1Kik
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40^tm1Kik mutation (11 available); any Cd40 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased neutrophil cell number ( J:25007 )

• in non-SPF facilities compared to wild-type controls

absent spleen germinal center ( J:25007 )

• failed to form

decreased immunoglobulin level ( J:25007 )

• reduced production of IgG1, IgG2a, IgG2b, IgG3, IgA, IgE in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• response to thymus-independent (TI) antigens was in tact

decreased IgA level ( J:25007 )

• reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• decreased serum concentrations in unimmunized mice

decreased IgE level ( J:25007 )

• reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• decreased serum concentrations in unimmunized mice

decreased IgG1 level ( J:25007 )

• reduced production of IgG1 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• decreased serum concentrations of IgG1 in unimmunized mice

decreased IgG2a level ( J:25007 )

• reduced production of IgG2a in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• decreased serum concentrations of IgG2a in unimmunized mice

decreased IgG2b level ( J:25007 )

• reduced production of IgG2b in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• decreased serum concentrations of IgG2b in unimmunized mice

decreased IgG3 level ( J:25007 )

• reduced production of IgG3 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• IgG3 serum concentrations in unimmunized mice are not decreased

immune system

immune system phenotype ( J:25007 )

N	• normal numbers and ratios of T and B cells

decreased neutrophil cell number ( J:25007 )

• in non-SPF facilities compared to wild-type controls

absent spleen germinal center ( J:25007 )

• failed to form

decreased susceptibility to type II hypersensitivity reaction ( J:61673 )

• in model of accelerated anti-glomerular basement membrane antibody-mediated glomerulonephritis

• deposition of IgG and complement in glomeruli not observed

• glomeruli almost normal

• fibrin deposition in glomeruli not observed

• failure to induce proteinuria

abnormal humoral immune response ( J:25007 )

decreased immunoglobulin level ( J:25007 )

• reduced production of IgG1, IgG2a, IgG2b, IgG3, IgA, IgE in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• response to thymus-independent (TI) antigens was in tact

decreased IgA level ( J:25007 )

• reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• decreased serum concentrations in unimmunized mice

decreased IgE level ( J:25007 )

• reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• decreased serum concentrations in unimmunized mice

decreased IgG1 level ( J:25007 )

• reduced production of IgG1 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• decreased serum concentrations of IgG1 in unimmunized mice

decreased IgG2a level ( J:25007 )

• reduced production of IgG2a in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• decreased serum concentrations of IgG2a in unimmunized mice

decreased IgG2b level ( J:25007 )

• reduced production of IgG2b in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• decreased serum concentrations of IgG2b in unimmunized mice

decreased IgG3 level ( J:25007 )

• reduced production of IgG3 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• IgG3 serum concentrations in unimmunized mice are not decreased

Allelic Composition	Cd40^tm1Kik/Cd40⁺ Mir146^tm1.1Lfl/Mir146^tm1.1Lfl Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40^tm1Kik mutation (11 available); any Cd40 mutation (42 available)
Mir146^tm1.1Lfl mutation (1 available); any Mir146 mutation (14 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:266124 )

N	• mice exhibit a restoration of normal IgG1 levels in B cells compared with Mir146^tm1.1Tmmc Tg(Cr2-cre)3Cgn mice

increased T follicular helper cell number ( J:266124 )

• following immunization with sheep red blood cells in mixed bone marrow chimeras

hematopoietic system

increased T follicular helper cell number ( J:266124 )

• following immunization with sheep red blood cells in mixed bone marrow chimeras

Allelic Composition	Cd40^tm1Kik/Cd40^tm1Kik Tg(Tnfsf13b)1Fma/?
Genetic Background	B6.Cg-Cd40^tm1Kik Tg(Tnfsf13b)1Fma

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40^tm1Kik mutation (11 available); any Cd40 mutation (42 available)
Tg(Tnfsf13b)1Fma mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal class switch recombination ( J:113556 )

• B cells exhibit reduced class switching in response to T cell-dependent antigens

increased marginal zone B cell number ( J:113556 )

• the number of splenic marginal zone B cells is increased by about 3-fold

absent spleen germinal center ( J:113556 )

• mice are defective in germinal center formation upon after immunization

abnormal B cell activation ( J:113556 )

• B cells have a vigorous response to T cell independent antigens producing much higher levels of antigen-specific IgG1, IgG2a, IgG2b, IgG3, and IgA class antibodies than controls

increased anti-double stranded DNA antibody level ( J:113556 )

• anti-dsDNA antibodies of the IgM class, IgA class, and all IgG subclasses are found in circulation

• titers of these auto-antibodies increase with age

glomerulonephritis ( J:113556 )

• kidneys of 10-month old mice have necrotic lesions

renal/urinary system

increased urine protein level ( J:113556 )

• all 8-month old mice have proteinuria in their urine at 100-300 mg/dl concentration

glomerulonephritis ( J:113556 )

• kidneys of 10-month old mice have necrotic lesions

renal glomerular immunoglobulin deposits ( J:113556 )

• immunohistology of kidneys with severe lesions reveal numerous glomerular deposits of IgG

homeostasis/metabolism

increased urine protein level ( J:113556 )

• all 8-month old mice have proteinuria in their urine at 100-300 mg/dl concentration

hematopoietic system

abnormal class switch recombination ( J:113556 )

• B cells exhibit reduced class switching in response to T cell-dependent antigens

increased marginal zone B cell number ( J:113556 )

• the number of splenic marginal zone B cells is increased by about 3-fold

absent spleen germinal center ( J:113556 )

• mice are defective in germinal center formation upon after immunization

abnormal B cell activation ( J:113556 )

• B cells have a vigorous response to T cell independent antigens producing much higher levels of antigen-specific IgG1, IgG2a, IgG2b, IgG3, and IgA class antibodies than controls

Allelic Composition	Cd40^tm1Kik/Cd40^tm1Kik Traf3ip2^tm1.1Lix/Traf3ip2^tm1.1Lix
Genetic Background	involves: 129 * 129P2/OlaHsd * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40^tm1Kik mutation (11 available); any Cd40 mutation (42 available)
Traf3ip2^tm1.1Lix mutation (0 available); any Traf3ip2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

enlarged spleen ( J:93923 )

• enlargement of the spleen is reduced compared to Traf3ip2 single homozygotes

• immunoglobulin levels are normal unlike in Traf3ip2 single homozygotes

increased transitional stage B cell number ( J:138560 )

• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes

increased follicular B cell number ( J:138560 )

• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes

increased marginal zone B cell number ( J:138560 )

• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes

abnormal B cell physiology ( J:138560 )

• Tnfsf13b (BAFF) stimulation results in enhanced B cell survival compared to single Cd40 mutants

immune system

immune system phenotype ( J:138560 )

N	• double mutants do not exhibit production of anti-SSA/Ro and anti-SSB/La autoantibodies in response to recombinant SSA/Ro and SSB/La antigens, as seen in Traf3ip2 single homozygotes

enlarged spleen ( J:93923 )

• enlargement of the spleen is reduced compared to Traf3ip2 single homozygotes

• immunoglobulin levels are normal unlike in Traf3ip2 single homozygotes

increased transitional stage B cell number ( J:138560 )

• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes

increased follicular B cell number ( J:138560 )

• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes

increased marginal zone B cell number ( J:138560 )

• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes

abnormal B cell physiology ( J:138560 )

• Tnfsf13b (BAFF) stimulation results in enhanced B cell survival compared to single Cd40 mutants

enlarged lymph nodes ( J:93923 )

• enlargement of the lymph nodes is reduced compared to Traf3ip2 single homozygotes

growth/size/body

enlarged spleen ( J:93923 )

• enlargement of the spleen is reduced compared to Traf3ip2 single homozygotes

• immunoglobulin levels are normal unlike in Traf3ip2 single homozygotes

Allelic Composition	Cd40^tm1Kik/Cd40^tm1Kik Tnfsf11^tm1Pngr/Tnfsf11^tm1Pngr
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40^tm1Kik mutation (11 available); any Cd40 mutation (42 available)
Tnfsf11^tm1Pngr mutation (0 available); any Tnfsf11 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal thymus epithelium morphology ( J:173115 )

• mice exhibit reduced MHC II^high and MHC II^low medullary thymic epithelial cells (mTEC) compared with wild-type mice

• mice exhibit fewer Aire+ medullary epithelial cells (mTEC) compared with wild-type mice

hematopoietic system

abnormal thymus epithelium morphology ( J:173115 )

• mice exhibit reduced MHC II^high and MHC II^low medullary thymic epithelial cells (mTEC) compared with wild-type mice

• mice exhibit fewer Aire+ medullary epithelial cells (mTEC) compared with wild-type mice

endocrine/exocrine glands

abnormal thymus epithelium morphology ( J:173115 )

• mice exhibit reduced MHC II^high and MHC II^low medullary thymic epithelial cells (mTEC) compared with wild-type mice

• mice exhibit fewer Aire+ medullary epithelial cells (mTEC) compared with wild-type mice

Allelic Composition	Bank1^tm1Kuro/Bank1^tm1Kuro Cd40^tm1Kik/Cd40^tm1Kik
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bank1^tm1Kuro mutation (0 available); any Bank1 mutation (59 available)
Cd40^tm1Kik mutation (11 available); any Cd40 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:113321 )

N	• increased IgM response and germinal center formation seen in Bank1 single homozygotes are absent in double homozygotes

Allelic Composition	Cd40^tm1Kik/Cd40^tm1Kik Tg(Igh-V-CD40lg)#Tsub/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40^tm1Kik mutation (11 available); any Cd40 mutation (42 available)
Tg(Igh-V-CD40lg)#Tsub mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:89855 )

Allelic Composition	Cd40^tm1Kik/Cd40^tm1Kik Ltbr^tm1Mmat/Ltbr^tm1Mmat
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40^tm1Kik mutation (11 available); any Cd40 mutation (42 available)
Ltbr^tm1Mmat mutation (1 available); any Ltbr mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:173115 )

N	• unlike Ltbr^tm1Mmat homozygotes, mice do not exhibit lymphoid cell aggregates

abnormal thymus epithelium morphology ( J:173115 )

• mice exhibit fewer MHC II^low medullary thymic epithelial cells compared to in wild-type mice

• mice exhibit fewer Aire+ medullary epithelial cells compared with wild-type mice

abnormal thymus medulla morphology ( J:173115 )

• medullary areas are smaller in size and less frequently connected to each other than in wild-type mice

hematopoietic system

abnormal thymus epithelium morphology ( J:173115 )

• mice exhibit fewer MHC II^low medullary thymic epithelial cells compared to in wild-type mice

• mice exhibit fewer Aire+ medullary epithelial cells compared with wild-type mice

abnormal thymus medulla morphology ( J:173115 )

• medullary areas are smaller in size and less frequently connected to each other than in wild-type mice

endocrine/exocrine glands

abnormal thymus epithelium morphology ( J:173115 )

• mice exhibit fewer MHC II^low medullary thymic epithelial cells compared to in wild-type mice

• mice exhibit fewer Aire+ medullary epithelial cells compared with wild-type mice

abnormal thymus medulla morphology ( J:173115 )

• medullary areas are smaller in size and less frequently connected to each other than in wild-type mice

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