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Targeted Allele Detail
Symbol: Cd40tm1Kik
Name: CD40 antigen; targeted mutation 1, Hitoshi Kikutani
MGI ID: MGI:1857457
Synonyms: CD40-, CD40 Ko, CD40KO, Tnfrsf5-, Tnfrsf5tm1Kik
Gene: Cd40  Location: Chr2:164897535-164913574 bp, + strand  Genetic Position: Chr2, 85.38 cM
Alliance: Cd40tm1Kik page
Germline Transmission:  Earliest citation of germline transmission: J:25007
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin cassette was inserted into exon 3. Disruption of the functionality of the protein was confirmed by a surface expression assay in spleen cells in which no binding of Tnfsf5 to ligand was observed. (J:25007)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 11 strains available      Cell Lines: 0 lines available
Carrying any Cd40 Mutation:  38 strains or lines available
Original:  J:25007 Kawabe T, et al., The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity. 1994 Jun;1(3):167-78
All:  231 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
The Jackson Laboratory