All Phenotypes Rbpj<+> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Rbpj^{tm1b(EUCOMM)Hmgu}/Rbpj⁺	C57BL/6N-Rbpj^{tm1b(EUCOMM)Hmgu}/J	MGI:6263345
ht2	Rbpj^tm1.1Hon/Rbpj⁺	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:7640228
ht3	Rbpj^tm1Kyo/Rbpj⁺	involves: 129S2/SvPas * CD-1	MGI:6236251
cn4	Rbpj^tm1Hon/Rbpj⁺ Tg(Tyr-cre)2Lru/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:3758750
cx5	Eogt^tm1.2Okaj/Eogt^tm1.2Okaj Rbpj^tm1.1Hon/Rbpj⁺	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA/2	MGI:7640229

Allelic Composition	Rbpj^{tm1b(EUCOMM)Hmgu}/Rbpj⁺
Genetic Background	C57BL/6N-Rbpj^{tm1b(EUCOMM)Hmgu}/J
Cell Lines	HEPD0733_5_F03

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbpj^{tm1b(EUCOMM)Hmgu} mutation (1 available); any Rbpj mutation (191 available)

Data Sources

IMPC Data for Rbpj

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased startle reflex ( J:211773 )

IMPC - JAX

increased grip strength ( J:211773 )

IMPC - JAX

homeostasis/metabolism

increased circulating bilirubin level ( J:211773 )

IMPC - JAX

decreased circulating HDL cholesterol level ( J:211773 )

IMPC - JAX

improved glucose tolerance ( J:211773 )

IMPC - JAX

skeleton

decreased bone mineral density ( J:211773 )

IMPC - JAX

Allelic Composition	Rbpj^tm1.1Hon/Rbpj⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbpj^tm1.1Hon mutation (1 available); any Rbpj mutation (191 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal retina vasculature morphology ( J:254752 )

• retinas exhibit elevated vessel branching at P5

vision/eye

abnormal retina vasculature morphology ( J:254752 )

• retinas exhibit elevated vessel branching at P5

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal aortic valve morphology ( J:187551 )

• collagen distribution is extended all over the valve area in mice fed a hypercholesterolemic diet supplemented with vitamin D (HCVD), indicating aortic valve fibrosis

calcified aortic valve cusp ( J:187551 )

• mice fed the HCVD diet exhibit extensive aortic valve leaflet calcification and develop calcific aortic disease after 16 weeks on this diet

thick aortic valve cusps ( J:187551 )

• mice exhibit increased leaflet thickness at 16 weeks on the HCVD diet

cardiac fibrosis ( J:187551 )

• mice fed the HCVD diet develop aortic valve fibrosis

decreased cardiac muscle contractility ( J:187551 )

• mice exhibit lower fractional shortening and ejection fraction after 4 months on the HCVD diet than wild-type mice on the same diet

abnormal heart echocardiography feature ( J:187551 )

• after 4 months of a hypercholesterolemic diet supplemented with vitamin D (HCVD), mice exhibit a higher aortic valve maximum velocity measured by echocardiography and higher transvalvular maximum velocity measured by continuous-wave Doppler imaging and lower ejection fraction velocity ratio values than controls

aortic valve inflammation ( J:187551 )

• mice fed the HCVD diet exhibit increased aortic valve inflammation, showing increased macrophage infiltration in the leaflets

immune system

aortic valve inflammation ( J:187551 )

• mice fed the HCVD diet exhibit increased aortic valve inflammation, showing increased macrophage infiltration in the leaflets

muscle

decreased cardiac muscle contractility ( J:187551 )

• mice exhibit lower fractional shortening and ejection fraction after 4 months on the HCVD diet than wild-type mice on the same diet

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
aortic valve disease		DOID:62		J:187551

Allelic Composition	Rbpj^tm1Hon/Rbpj⁺ Tg(Tyr-cre)2Lru/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbpj^tm1Hon mutation (2 available); any Rbpj mutation (191 available)
Tg(Tyr-cre)2Lru mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

pigmentation phenotype ( J:116658 )

N	• loss of one allele has no affect on coat color; no graying or dilution is observed in 8-week old mice

Allelic Composition	Eogt^tm1.2Okaj/Eogt^tm1.2Okaj Rbpj^tm1.1Hon/Rbpj⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eogt^tm1.2Okaj mutation (0 available); any Eogt mutation (44 available)
Rbpj^tm1.1Hon mutation (1 available); any Rbpj mutation (191 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal retina vasculature morphology ( J:254752 )

• retinas exhibit enhanced elevation in vessel branching at P5 than single Rbpj heterozygotes

increased vascular permeability ( J:254752 )

• retinas show greater extravascular fibrinogen staining and extravasation of perfused sulfo-NHS-LC-biotin, indicating greater impaired vascular integrity than single Eogt homozygotes

vision/eye

abnormal retina vasculature morphology ( J:254752 )

• retinas exhibit enhanced elevation in vessel branching at P5 than single Rbpj heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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