Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plattm1Mlg mutation
(6 available);
any
Plat mutation
(61 available)
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immune system
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• mice infected with a sublethal dose of mouse-adapted SARS-CoV MA15 show a slight, but not significant, acceleration in recovery of weight loss compared to controls
• mice infected with a lethal dose of SARS-CoV MA15 show early mortality compared to wild-type controls, although mice that survive early infection recover
• SARS-CoV MA15 lethally infected mice show a trend toward less hemorrhage in the lungs
• however, SARS-CoV MA15-infected mice show similar viral loads in the lung at 4 and 7 days post infection as wild-type controls
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• mice infected with a lethal dose of SARS-CoV MA15 show early mortality compared to wild-type controls, although mice that survive early infection recover
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mortality/aging
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• mice infected with a lethal dose of SARS-CoV MA15 show early mortality compared to wild-type controls, although mice that survive early infection recover
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plattm1Mlg mutation
(6 available);
any
Plat mutation
(61 available)
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behavior/neurological
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• homozygotes show normal footshock sensitivity thresholds relative to wild-type mice
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• homozygotes show no significant differences in the antinociceptive effect of morphine or development of its tolerance relative to wild-type mice
• notably, homozygotes display a significant reduction in morphine-induced hyperlocomotion relative to wild-type
• the defect of morphine-induced hyperlocomotion is reversed by exogenous administration of tPA or plasmin into the nucleus accumbens (Nacc)
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• homozygotes display poor active avoidance behavior relative to wild-type mice
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• homozygotes display a significant reduction in morphine-induced conditioned place preference
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• homozygotes display poor contextual fear conditioning behavior relative to wild-type mice, indicating impaired hippocampal function
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• homozygotes display enhanced cue fear conditioning behavior relative to wild-type mice
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• relative to wild-type, mutant mice exhibit a 28% reduction in both the rate and extent of learning a complex motor paradigm of irregular peg running, indicating impaired cerebellar motor learning
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• homozygotes display no habitation of object exploration relative to wild-type mice
• homozygotes show no reactivity to spatial change (measured as renewed exploration of displaced objects) relative to wild-type mice
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• after up to 3 weeks of daily restraint, homozygotes exhibit absence of stress-induced anxiety in the elevated-plus maze; in wild-type, acute stress resuls in a decrease in open arm entries, with 21 days of daily restraint leading to some habituation
(J:81694)
• in response to a low or middle dose of corticotropin-releasing factor (CRF), homozygotes exhibit reduced anxiety (lower number of open arm entries) in the elevated plus-maze, with an increased number of head dips (increased exploration) relative to wild-type
(J:94733)
• in response to a high dose of CRF, homozygotes fail to explore the open arms but display a similar number of closed arms entries relative to wild-type mice, indicating normal locomotor activity
(J:94733)
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• in an empty open field, homozygotes show normal horizontal activity but significantly reduced rearing activity relative to wild-type
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homeostasis/metabolism
immune system
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• in a model of collagen-induced arthritis, severely affected joints from homozygotes display diffuse fibrin(ogen) deposition relative to wild-type
• within arthritic joints, higher fibrin levels appear to correlate with increased disease severity
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• in a model of collagen-induced arthritis, arthritic homozygotes exhibit a significant increase in interleukin-1beta levels in the synovium relative to wild-type
• in a model of collagen-induced arthritis, ankle joint washouts from arthritic homozygotes exhibit a significant increase in TNF levels relative to wild-type
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• in a model of collagen-induced arthritis, homozygotes develop significant joint inflammation and joint destruction relative to wild-type mice
• severely affected joints from arthritic homozygotes exhibit massive cell infiltration and higher proteoglycan depletion than wild-type mice
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• in a model of collagen-induced arthritis, homozygotes develop a significantly more severe arthritis than wild-type mice
• 95% of mutant mice develop arthritis compared with 68% of wild-type mice; no difference in the day of disease onset is observed
• severely affected joints from arthritic homozygotes exhibit higher cartilage damage and bone erosions than wild-type mice
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muscle
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• in response to glycerol-induced injury, homozygotes exhibit normal skeletal muscle regeneration after 5 days; regeneration is complete after 9 days
• at 7 days after injury, most injured fibers regenerate into groups of centrally nucleated myotubes, indicating advanced regeneration; only few necrotic fibers are observed
• at 20 days after injury, virtually no signs of muscle injury are detected, except for centrally located myonuclei inside the regenerated fibers
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skeleton
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• in a model of collagen-induced arthritis, 60% of mutant mice have 3 or 4 affected limbs compared with only 18% of wild-type mice
• in arthritic mutants, 45% of affected individual limbs display severe swelling and/or rigidity compared with only 19% from wild-type
• there are no differences in the degree of swelling (i.e. paw thickness) between limbs from mutant and wild-type mice with the same clinical score
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• in a model of collagen-induced arthritis, homozygotes develop significant joint inflammation and joint destruction relative to wild-type mice
• severely affected joints from arthritic homozygotes exhibit massive cell infiltration and higher proteoglycan depletion than wild-type mice
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• in a model of collagen-induced arthritis, homozygotes develop a significantly more severe arthritis than wild-type mice
• 95% of mutant mice develop arthritis compared with 68% of wild-type mice; no difference in the day of disease onset is observed
• severely affected joints from arthritic homozygotes exhibit higher cartilage damage and bone erosions than wild-type mice
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nervous system
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• after restraint, homozygotes show reduced neuronal remodeling in the medial amygdala, with absence of stress-induced ERK1/2 phosphorylation at all time points tested
(J:81694)
• in response to CRF, homozygotes exhibit attenuated expression of Fos (an indicator of neuronal activation) in the central and medial amygdala but show normal Fos responses in paraventricular nuclei
(J:94733)
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• in response to tetanic stimulation, hippocampal CA1 slices from mutant mice show a significant reduction in the late phase of LTP relative to wild-type
• notably, a slight but significant reduction of the early phase of hippocampal LTP is also observed
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• in response to tetanic stimulation of corticostriatal fibers, homozygotes display absence of LTD in a significant portion of striatal neurons
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plattm1Mlg mutation
(6 available);
any
Plat mutation
(61 available)
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nervous system
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• significant decrease in the number of activated glial cells in ischemic tissue after transient middle cerebral artery occlusion
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• significant decrease in the number of activated glial cells in ischemic tissue after transient middle cerebral artery occlusion
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homeostasis/metabolism
immune system
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• significant decrease in the number of activated glial cells in ischemic tissue after transient middle cerebral artery occlusion
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hematopoietic system
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• significant decrease in the number of activated glial cells in ischemic tissue after transient middle cerebral artery occlusion
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plattm1Mlg mutation
(6 available);
any
Plat mutation
(61 available)
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mortality/aging
N |
• homozygotes display a normal lifespan relative to wild-type mice
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cardiovascular system
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• in response to laser-induced injury of the Bruch's membrane, homozygotes display almost complete absence of choroidal neovascularization (CNV) at the site of trauma; in contrast, wild-type mice show a robust neovascular reaction
• resistance to CNV is associated with excessive fibrinogen-fibrin deposition at the site of choroidal trauma and in retinal vessels
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• at 2 weeks after transverse aortic banding (TAB) i.e. acute pressure overload, homozygotes and wild-type mice exhibit a significant LV hypertrophy which persists for up to 7 weeks
• similar to wild-type mice, homozygotes display a ~35% increase in LV/body weight ratio and a ~40% increase in the LV cardiomyocyte size
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• in response to pressure overload, wild-type and mutant mice display similar signs of maladaptation (i.e. myolysis, myocardial fibrosis and increased intercapillary distance)
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• 11 days after bleomycin treatment, mutant lungs show areas of fibrosis surrounded by areas of extensive intra-alveolar hemorrhage
• hemorrhagic areas contain numerous hemosiderin-laden macrophages, indicating chronic pulmonary hemorrhage
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• in a photothrombotic model of middle cerebral artery occlusion (MCAO), delayed heparin administration increases cerebral hemorrhage associated with ischemia in wild-type but NOT in mutant mice
• in this MCAO model, heparin administration induces tPA activity and mRNA expression in microglial cells, and enhances MMP9 expression and proteolytic activation in the ischemic brains of wild-type but NOT of mutant mice
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• at 7 weeks after TAB, wild-type and mutant mice exhibit a similar degree of LV dilatation, obvious signs of LV systolic dysfunction, and pump failure
• at 7 weeks after TAB, impaired fractional shortening and abnormal cardiac pump result in respiratory distress due to pulmonary congestion
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growth/size/body
N |
• at 5 weeks of age, homozygotes exhibit a normal body weight relative to wild-type mice
• no macroscopic or histologic abnormalities are observed up to 14 months of age
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• at 2 weeks after transverse aortic banding (TAB) i.e. acute pressure overload, homozygotes and wild-type mice exhibit a significant LV hypertrophy which persists for up to 7 weeks
• similar to wild-type mice, homozygotes display a ~35% increase in LV/body weight ratio and a ~40% increase in the LV cardiomyocyte size
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hematopoietic system
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• bleomycin-treated homozygotes display a delayed, but significant, increase in macrophage levels reaching wild-type levels at 9 days post-drug treatment
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immune system
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• homozygotes exhibit normal matrix degradation and invasion into the peritoneal cavity by thioglycollate-stimulated macrophages
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• bleomycin-treated homozygotes display a delayed, but significant, increase in macrophage levels reaching wild-type levels at 9 days post-drug treatment
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• after bleomycin treatment, homozygotes exhibit areas of fibrin(ogen) deposits, especially in the vasculature of the lung, where fibrin thrombi are observed
(J:63134)
• after laser-induced injury of the Bruch's membrane, homozygotes show massive accumulation of fibrinogen-fibrin both in the retinal vessels, and in the bottom of the laser-induced trauma
(J:82604)
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muscle
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• similar to wild-type mice, homozygotes display a ~35% increase in LV/body weight ratio and a ~40% increase in the LV cardiomyocyte size
• at 2 weeks after transverse aortic banding (TAB) i.e. acute pressure overload, homozygotes and wild-type mice exhibit a significant LV hypertrophy which persists for up to 7 weeks
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• at 7 weeks after TAB, wild-type and mutant mice exhibit a similar degree of LV dilatation, obvious signs of LV systolic dysfunction, and pump failure
• at 7 weeks after TAB, impaired fractional shortening and abnormal cardiac pump result in respiratory distress due to pulmonary congestion
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reproductive system
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• homozygotes display normal litter size and frequency of litters relative to wild-type mice
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respiratory system
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• 11 days after bleomycin treatment, mutant lungs show areas of fibrosis surrounded by areas of extensive intra-alveolar hemorrhage
• hemorrhagic areas contain numerous hemosiderin-laden macrophages, indicating chronic pulmonary hemorrhage
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• bleomycin-treated homozygotes exhibit an enhanced increase in lung hydroxyproline (collagen) content relative to bleomycin-treated wild-type mice
• histological analysis after lung injury indicates extensive interstitial fibrosis in mutant mice relative to wild-type
• notably, homozygotes survive only 11 days post-drug treatment
• 75% of bleomycin-treated homozygotes die as early as 7 days after treatment, as a result of hemorrhage and extensive fibrotic lesions
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vision/eye
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• in response to laser-induced injury of the Bruch's membrane, homozygotes display almost complete absence of choroidal neovascularization (CNV) at the site of trauma; in contrast, wild-type mice show a robust neovascular reaction
• resistance to CNV is associated with excessive fibrinogen-fibrin deposition at the site of choroidal trauma and in retinal vessels
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• at higher doses of NMDA, homozygotes show no differences in retinal damage relative to wild-type mice
• at 12 and 24 h after intravitreal injection of low-dose (30 nmol/mouse) NMDA, homozygotes contain significantly less retinal apoptotic neurons in the ganglion cell layer (GCL) and inner nuclear layer (INL) relative to wild-type; no differences are noted at 72 h after low-dose NMDA injection
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• homozygotes are partially resistant to NMDA-induced retinal damage relative to wild-type mice
• in contrast, neither intravitreal kainic acid nor transient ischemia results in significant differences in retinal damage in mutant vs. wild-type mice
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nervous system
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• in a photothrombotic model of middle cerebral artery occlusion (MCAO), delayed heparin administration increases cerebral hemorrhage associated with ischemia in wild-type but NOT in mutant mice
• in this MCAO model, heparin administration induces tPA activity and mRNA expression in microglial cells, and enhances MMP9 expression and proteolytic activation in the ischemic brains of wild-type but NOT of mutant mice
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• homozygotes subjected to focal cerebral ischemia induced by persistent occlusion of the left middle cerebral artery produce an infarct with a size that is significantly smaller than that produced in wild-type mice
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homeostasis/metabolism
cellular
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• in response to pressure overload, wild-type and mutant mice display similar signs of maladaptation (i.e. myolysis, myocardial fibrosis and increased intercapillary distance)
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• at 12 and 24 h after intravitreal injection of low-dose (30 nmol/mouse) NMDA, homozygotes contain significantly less retinal apoptotic neurons in the ganglion cell layer (GCL) and inner nuclear layer (INL) relative to wild-type; no differences are noted at 72 h after low-dose NMDA injection
• at higher doses of NMDA, homozygotes show no differences in retinal damage relative to wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plattm1Mlg mutation
(6 available);
any
Plat mutation
(61 available)
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cardiovascular system
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• aortic vessel explants show almost complete inhibition of capillary sprouting in both collagen lattices and Matrigel
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plattm1Mlg mutation
(6 available);
any
Plat mutation
(61 available)
Thbdtm2Rdr mutation
(0 available);
any
Thbd mutation
(23 available)
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mortality/aging
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• double homozygotes exhibit a reduced lifespan with 17% dying at ~17 weeks of age
• 9 out of 22 double homozygotes survive until the end of an observation period of 30-40 weeks; only 3 out of 10 double mutants survive until 40-50 weeks
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integument
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• at 8-12 weeks of age, 5% of double homozygotes show extensive non-healing ulcerations at the face
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• at 8-12 weeks of age, 5% of double homozygotes show extensive non-healing ulcerations at the ears around the eartag
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cellular
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• pre-terminal double mutants display intestinal adhesions and occasionally ischemic tissue necrosis (uterus and intestines), possibly due to thrombosis
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digestive/alimentary system
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• at 8-12 weeks of age, 37% of double homozygotes display rectal prolapse of a non-infectious origin
• in double mutants, rectal prolapse develops with variable penetrance and onset but appears significantly earlier and at a much higher incidence than in single mutant mice
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growth/size/body
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• at 8-12 weeks of age, 5% of double homozygotes show extensive non-healing ulcerations at the face
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• at 8-12 weeks of age, 5% of double homozygotes show extensive non-healing ulcerations at the ears around the eartag
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• at ~17 weeks, 17% of double homozygotes appear runted prior to death
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• at 23 weeks, the body weight of double homozygotes is approximately 2/3 that of wild-type mice
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• at ~17 weeks, 17% of double homozygotes exhibit cachexia prior to death
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• after 3 weeks of age, double homozygotes appear growth retarded relative to wild-type mice
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hearing/vestibular/ear
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• at 8-12 weeks of age, 5% of double homozygotes show extensive non-healing ulcerations at the ears around the eartag
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reproductive system
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• double homozygotes display a significant reduction in fertility possibly because of poor health or large fibrin deposition in the gonads
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• double homozygous breeding pairs produce slightly fewer offspring per litter than wild-type breeding pairs
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respiratory system
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• at ~17 weeks, 17% of double homozygotes exhibit dyspnea prior to death
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vision/eye
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• at 8-12 weeks of age, 5% of double homozygotes exhibit extensive non-healing ulcerations at the eyelids
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homeostasis/metabolism
craniofacial
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• at 8-12 weeks of age, 5% of double homozygotes show extensive non-healing ulcerations at the face
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• at 8-12 weeks of age, 5% of double homozygotes show extensive non-healing ulcerations at the ears around the eartag
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