All Phenotypes Foxq1<sa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Foxq1^sa
satin
MGI:1857026

Summary

20 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxq1^sa/Foxq1^sa	involves: 101/Rl * C3H/Rl	MGI:3582960
cx2	Foxq1^sa/Foxq1⁺ sau/sau⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:3607722
cx3	sau/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:3607793
cx4	Foxq1^sa/Foxq1⁺ Sox4^M91Ark/Del(13)36H	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:3819858
cx5	M1645b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516039
cx6	M876b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516047
cx7	Foxq1^sa/Foxq1⁺ M876b/+	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516049
cx8	Foxq1^sa/Foxq1⁺ Sox4^M91Ark/Sox4⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516058
cx9	Foxq1^sa/Foxq1⁺ M1073b/Del(13)36H	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516034
cx10	Foxq1^sa/Foxq1⁺ M1073b/+	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516036
cx11	M1185b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516037
cx12	M1616b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516038
cx13	M241b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516040
cx14	M369b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516041
cx15	Foxq1^sa/Foxq1⁺ M369b/+	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516043
cx16	M412b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516044
cx17	M54b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516045
cx18	M624b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516046
cx19	Foxq1^sa/Foxq1^sa Lyst^bg/Lyst^bg	involves: 101/Rl * C3H/Rl * C57BL10/Rl	MGI:3847105
cx20	Foxq1^sa/Foxq1^sa Lyst^bg/Lyst^bg	involves: 101/Rl * C3H/Rl * C57BL/6J * C57BL10/Rl	MGI:3847098

Allelic Composition	Foxq1^sa/Foxq1^sa
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxq1^sa mutation (16 available); any Foxq1 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired natural killer cell mediated cytotoxicity ( J:7649 )

• NK cells showed variable ability to kill but always below normal compared to non-satin mice from same background

• kill ability was significantly suppressed when this allele is heterozygous with Lyst^bg

integument

abnormal coat appearance ( J:15247 )

abnormal hair growth ( J:15247 )

• all four hair types are thin

• cortex is slightly thicker; medullary component is much reduced

shiny fur ( J:15247 )

• results from structural abnormalities of the medulla and defects in the hair shaft

abnormal hair shaft morphology ( J:15247 )

• medullary cells elongate as they enter the hair shaft producing a cylider of cells rather than delicate network

• keratinization is not observed

hematopoietic system

impaired natural killer cell mediated cytotoxicity ( J:7649 )

• NK cells showed variable ability to kill but always below normal compared to non-satin mice from same background

• kill ability was significantly suppressed when this allele is heterozygous with Lyst^bg

Allelic Composition	Foxq1^sa/Foxq1⁺ sau/sau⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxq1^sa mutation (16 available); any Foxq1 mutation (24 available)
sau mutation (2 available); any sau mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased thigmotaxis ( J:101156 )

• heterozygous mice exhibit heightened anxiety in the Open Field Activity test, entering the center of the field 29% less frequently than littermate controls

Allelic Composition	sau/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (24 available)
sau mutation (2 available); any sau mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:101156 )

• hemizygous progeny are born at less than one-third the expected Mendelian frequency, most dying by 16.5 days post coitum (16.5 dpc)

nervous system

holoprosencephaly ( J:101156 )

• hemizygous embyros examined at 9.5 dpc often exhibit midline forebrain defects and other aspects of holoprocencephaly

• some hemizygotes that survive to birth exhibit holoprosencephalic phenotypes of varying severity

vision/eye

abnormal eye development ( J:101156 )

• some hemizygous embryos and liveborn pups exhibit structural eye defects

cyclopia ( J:101156 )

Allelic Composition	Foxq1^sa/Foxq1⁺ Sox4^M91Ark/Del(13)36H
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (24 available)
Sox4^M91Ark mutation (2 available); any Sox4 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:101156 )

• almost all mice die before birth, with a significant deviation from expected Mendelian frequencies first noted at E14.5

cardiovascular system

abnormal aortic arch morphology ( J:101156 )

• smaller than the pulmonary artery

abnormal cardiovascular development ( J:101156 )

• circulatory failure

abnormal heart morphology ( J:101156 )

abnormal heart development ( J:101156 )

• common atrioventricular junction

double outlet right ventricle ( J:101156 )

• the aorta and pulmonary artery both originate from the right ventricle

abnormal mitral valve morphology ( J:101156 )

• the mitral valve of E14.5 embryos is dysplastic

ostium primum atrial septal defect ( J:101156 )

• a primum atrial septal defect is seen at the ventral margin of the primary atrial septum in E14.5 embryos

ventricular septal defect ( J:101156 )

• a large ventricular septum defect connects the left and right ventricles

renal/urinary system

abnormal kidney development ( J:101156 )

• kidneys of E14.5 embryos are hypoplastic and occasionally positioned abnormally

renal hypoplasia ( J:101156 )

nervous system

holoprosencephaly ( J:101156 )

Allelic Composition	M1645b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (24 available)
M1645b mutation (2 available); any M1645b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:101156 )

• lethality occurs in the second half of gestation

Allelic Composition	M876b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (24 available)
M876b mutation (2 available); any M876b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:101156 )

• lethality occurs in the second half of gestation

Allelic Composition	Foxq1^sa/Foxq1⁺ M876b/+
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxq1^sa mutation (16 available); any Foxq1 mutation (24 available)
M876b mutation (2 available); any M876b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased anxiety-related response ( J:101156 )

• decreased cumulative center entries in an open field

nervous system

decreased prepulse inhibition ( J:101156 )

Allelic Composition	Foxq1^sa/Foxq1⁺ Sox4^M91Ark/Sox4⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxq1^sa mutation (16 available); any Foxq1 mutation (24 available)
Sox4^M91Ark mutation (2 available); any Sox4 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased anxiety-related response ( J:101156 )

• mice have a 31% decrease compared to controls in how many times the central portion of an open field test is entered

• mice also have additional reductions in total distance traveled (22% decrease) and movement time (14% decrease) in the open field tests

Allelic Composition	Foxq1^sa/Foxq1⁺ M1073b/Del(13)36H
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (24 available)
M1073b mutation (2 available); any M1073b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:101156 )

• lethality occurs in the second half of gestation

craniofacial

abnormal craniofacial morphology ( J:101156 )

abnormal tooth morphology ( J:101156 )

absent mandible ( J:101156 )

• microagnathia/agnathia

micrognathia ( J:101156 )

• microagnathia/agnathia

abnormal palate morphology ( J:101156 )

nervous system

holoprosencephaly ( J:101156 )

abnormal forebrain morphology ( J:101156 )

hearing/vestibular/ear

abnormal ear morphology ( J:101156 )

vision/eye

abnormal eye morphology ( J:101156 )

digestive/alimentary system

abnormal palate morphology ( J:101156 )

skeleton

abnormal tooth morphology ( J:101156 )

absent mandible ( J:101156 )

• microagnathia/agnathia

micrognathia ( J:101156 )

• microagnathia/agnathia

growth/size/body

abnormal tooth morphology ( J:101156 )

abnormal palate morphology ( J:101156 )

microcephaly ( J:101156 )

Allelic Composition	Foxq1^sa/Foxq1⁺ M1073b/+
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxq1^sa mutation (16 available); any Foxq1 mutation (24 available)
M1073b mutation (2 available); any M1073b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased anxiety-related response ( J:101156 )

• increased cumulative center entries in an open field

Allelic Composition	M1185b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (24 available)
M1185b mutation (2 available); any M1185b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:101156 )

• lethality occurs in the second half of gestation

cardiovascular system

abnormal heart morphology ( J:101156 )

Allelic Composition	M1616b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (24 available)
M1616b mutation (2 available); any M1616b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:101156 )

• lethality occurs in the second half of gestation

embryo

failure of chorioallantoic fusion ( J:101156 )

Allelic Composition	M241b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (24 available)
M241b mutation (2 available); any M241b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:101156 )

• lethality occurs in the second half of gestation

nervous system

holoprosencephaly ( J:101156 )

abnormal forebrain morphology ( J:101156 )

vision/eye

anophthalmia ( J:101156 )

• without micrognathia

Allelic Composition	M369b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (24 available)
M369b mutation (2 available); any M369b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:101156 )

• lethality occurs in the second half of gestation

nervous system

exencephaly ( J:101156 )

Allelic Composition	Foxq1^sa/Foxq1⁺ M369b/+
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxq1^sa mutation (16 available); any Foxq1 mutation (24 available)
M369b mutation (2 available); any M369b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hyperactivity ( J:101156 )

• increased activity and center entries in an open field

Allelic Composition	M412b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (24 available)
M412b mutation (2 available); any M412b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:101156 )

• lethality occurs in the second half of gestation

craniofacial

abnormal craniofacial morphology ( J:101156 )

abnormal tooth morphology ( J:101156 )

absent mandible ( J:101156 )

• microagnathia/agnathia

micrognathia ( J:101156 )

• microagnathia/agnathia

abnormal palate morphology ( J:101156 )

nervous system

holoprosencephaly ( J:101156 )

abnormal forebrain morphology ( J:101156 )

abnormal lateral ventricle morphology ( J:101156 )

• hypoplastic with no development of the interhemispheric fissure

abnormal hindbrain morphology ( J:101156 )

hearing/vestibular/ear

abnormal ear morphology ( J:101156 )

vision/eye

abnormal eye morphology ( J:101156 )

digestive/alimentary system

abnormal palate morphology ( J:101156 )

skeleton

abnormal tooth morphology ( J:101156 )

absent mandible ( J:101156 )

• microagnathia/agnathia

micrognathia ( J:101156 )

• microagnathia/agnathia

growth/size/body

abnormal tooth morphology ( J:101156 )

abnormal palate morphology ( J:101156 )

microcephaly ( J:101156 )

Allelic Composition	M54b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (24 available)
M54b mutation (2 available); any M54b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:101156 )

• lethality occurs in the second half of gestation

craniofacial

abnormal craniofacial morphology ( J:101156 )

abnormal tooth morphology ( J:101156 )

absent mandible ( J:101156 )

• microagnathia/agnathia

micrognathia ( J:101156 )

• microagnathia/agnathia

abnormal palate morphology ( J:101156 )

nervous system

holoprosencephaly ( J:101156 )

abnormal forebrain morphology ( J:101156 )

abnormal lateral ventricle morphology ( J:101156 )

• hypoplastic with no development of the interhemispheric fissure

hearing/vestibular/ear

abnormal ear morphology ( J:101156 )

• absence of ear pinnae at E15.5

vision/eye

anophthalmia ( J:101156 )

digestive/alimentary system

abnormal palate morphology ( J:101156 )

skeleton

abnormal tooth morphology ( J:101156 )

absent mandible ( J:101156 )

• microagnathia/agnathia

micrognathia ( J:101156 )

• microagnathia/agnathia

growth/size/body

abnormal tooth morphology ( J:101156 )

abnormal palate morphology ( J:101156 )

microcephaly ( J:101156 )

Allelic Composition	M624b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (24 available)
M624b mutation (2 available); any M624b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:101156 )

• lethality occurs in the second half of gestation

nervous system

holoprosencephaly ( J:101156 )

abnormal forebrain morphology ( J:101156 )

vision/eye

abnormal eye morphology ( J:101156 )

• a single, ventrally displaced eye

Allelic Composition	Foxq1^sa/Foxq1^sa Lyst^bg/Lyst^bg
Genetic Background	involves: 101/Rl * C3H/Rl * C57BL10/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxq1^sa mutation (16 available); any Foxq1 mutation (24 available)
Lyst^bg mutation (6 available); any Lyst mutation (153 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

enlarged spleen ( J:5311 )

• usually enlarged in the presence of pulmonary disease

lung inflammation ( J:5311 )

• showed either adhesions only or consolidation with or without adhesions

interstitial pneumonia ( J:5311 )

• 70% of mice develop progressive pneumonitis by 6 months of age

• histologic samples of lobes with adhesions revealed underlying pneumonitis

respiratory system

lung inflammation ( J:5311 )

• showed either adhesions only or consolidation with or without adhesions

interstitial pneumonia ( J:5311 )

• 70% of mice develop progressive pneumonitis by 6 months of age

• histologic samples of lobes with adhesions revealed underlying pneumonitis

growth/size/body

weight loss ( J:5311 )

• weight loss, particularly in males, is coincident with pneumonitis

enlarged spleen ( J:5311 )

• usually enlarged in the presence of pulmonary disease

hematopoietic system

enlarged spleen ( J:5311 )

• usually enlarged in the presence of pulmonary disease

Allelic Composition	Foxq1^sa/Foxq1^sa Lyst^bg/Lyst^bg
Genetic Background	involves: 101/Rl * C3H/Rl * C57BL/6J * C57BL10/Rl

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:15166 )

• mice die of pneumonitis during the first year of life

immune system

enlarged lymph nodes ( J:5311 )

interstitial pneumonia ( J:5311 , J:15166 )

• Background Sensitivity: by 6 months of age 49% of beige and 11% of nonbeige backcross offspring from an outcross to C57BL/6J-A^w-J develop progressive pneumonitis compared to 70% without C57BL/6J in the background (J:5311)

• mice die with pneumonitis during the first year of life (J:15166)

increased susceptibility to infection ( J:5311 )

• specific action of the mutation Lyst^bg increases susceptibility to progressive pneumonitis

respiratory system

interstitial pneumonia ( J:5311 , J:15166 )

• mice die with pneumonitis during the first year of life (J:15166)

neoplasm

increased lymphoma incidence ( J:5311 )

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