Phenotypes associated with this allele

• Allele Symbol: Fmn1^{ld-Is(17;In2)1Gso}
• Allele Name: limb deformity insertion 1 Generoso
• Allele ID: MGI:1856338
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Fmn1^tm1Awb/Fmn1^ld-Is(17;In2)1Gso	involves: 101/Rl * 129S4/SvJae * C3H/Rl * NIH Black Swiss	MGI:3801003
cx2	a^jIs(17;In2)1Gso/a^jIs(17;In2)1Gso Fmn1^ld-Is(17;In2)1Gso/Fmn1^ld-Is(17;In2)1Gso	involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl	MGI:3811460

Genotype
MGI:3801003

ht1

• Allelic Composition: Fmn1^tm1Awb/Fmn1^{ld-Is(17;In2)1Gso}
• Genetic Background: involves: 101/Rl * 129S4/SvJae * C3H/Rl * NIH Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

polycystic kidney ( J:43337 )

• a small percentage of mice display bilateral multicystic dysplastic kidneys

limbs/digits/tail

limbs/digits/tail phenotype ( J:43337 )

N • unlike mice homozygous for Fmn1^{ld-Is(17;In2)1Gso} no limb deformities are detected

growth/size/body

polycystic kidney ( J:43337 )

• a small percentage of mice display bilateral multicystic dysplastic kidneys

Genotype
MGI:3811460

cx2

• Allelic Composition: a^{jIs(17;In2)1Gso}/a^{jIs(17;In2)1Gso}; Fmn1^{ld-Is(17;In2)1Gso}/Fmn1^{ld-Is(17;In2)1Gso}
• Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

limbs/digits/tail

abnormal autopod morphology ( J:10399 )

• many mice exhibit hindfeet that only contain a single digit or the foot articulates with a projection from the side of the tibia instead of from the distal end of the tibia

abnormal autopod rotation ( J:10399 )

• some mice exhibit hindfeet that point in the wrong direction

abnormal carpal bone morphology ( J:10399 )

• mice exhibit aplasia or hypoplasia of some carpals

fused carpal bones ( J:10399 )

• in some mice

brachydactyly ( J:10399 )

• in some mice

oligodactyly ( J:10399 )

• mice lack at least 2 digits on each extremity

syndactyly ( J:10399 )

• in some mice

abnormal tarsal bone morphology ( J:10399 )

• mice exhibit aplasia or hypoplasia of many tarsals

fused tarsal bones ( J:10399 )

• in some mice

abnormal forelimb morphology ( J:10399 )

abnormal radius morphology ( J:10399 )

• mice exhibit radioulnar synostosis

radius hypoplasia ( J:10399 )

abnormal ulna morphology ( J:10399 )

• mice exhibit radioulnar synostosis

abnormal hindlimb morphology ( J:10399 )

absent fibula ( J:10399 )

• mice exhibit complete fibular aplasia

abnormal patella morphology ( J:10399 )

• some mice exhibit malpositioning of the patella

renal/urinary system

hydronephrosis ( J:10399 )

• in 6 of 9 mice with limb defects

renal hypoplasia ( J:10399 )

• one mouse with limb defects exhibits unilateral kidney aplasia associated with hypoplasia

• in 10 of 80 mice with limb defects

single kidney ( J:10399 )

• one mouse with limb defects exhibits unilateral kidney aplasia associated with hypoplasia

• in 2 of 80 mice with limb defects

dilated ureter ( J:10399 )

• 17 of 80 mice with limb defects exhibit dilation of one or both ureters

hydroureter ( J:10399 )

• in 6 of 9 mice with limb defects

skeleton

abnormal carpal bone morphology ( J:10399 )

• mice exhibit aplasia or hypoplasia of some carpals

fused carpal bones ( J:10399 )

• in some mice

abnormal tarsal bone morphology ( J:10399 )

• mice exhibit aplasia or hypoplasia of many tarsals

fused tarsal bones ( J:10399 )

• in some mice

abnormal radius morphology ( J:10399 )

• mice exhibit radioulnar synostosis

radius hypoplasia ( J:10399 )

abnormal ulna morphology ( J:10399 )

• mice exhibit radioulnar synostosis

absent fibula ( J:10399 )

• mice exhibit complete fibular aplasia

abnormal patella morphology ( J:10399 )

• some mice exhibit malpositioning of the patella

synostosis ( J:10399 )

• mice exhibit radioulnar synostosis

pigmentation

darkened coat color ( J:10399 )

• mice are black

integument

darkened coat color ( J:10399 )

• mice are black