Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(17)Thp mutation
(3 available);
any
Del(17)Thp mutation
(2 available)
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Allelic
Composition |
Del(17)Thp/+
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Genetic
Background |
involves: AKR/J * C57BL/Gr * CBA/Gr |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(17)Thp mutation
(3 available);
any
Del(17)Thp mutation
(2 available)
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limbs/digits/tail
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• on the hind feet of embryos inheriting the Thp allele from their mother
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• at E12 the base of the tail is constricted; the thickness of the tail itself varies
• at E13 the tail distal to the constriction is thinned
• by E14 the tail is thinned to a filament which often drops off resulting in a blunt-ended tail or tail rudiment
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• shortened by varying amounts
• the only abnormality seen in older embryos
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• degree of thickness varies
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reproductive system
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• litters from carrier males and normal females are reduced compared to normal; litters from matings of carrier females and normal males are even smaller in size
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homeostasis/metabolism
growth/size/body
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• characteristic of mice inheriting the Thp allele from their father
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embryo
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• at E10 the neural tube of the tail region is often doubled or tripled in embryos inheriting the Thp allele from their mother
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• characteristic of some E10 embryos inheriting the Thp allele from their father
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• occurs at a low frequency among embryos inheriting the Thp allele from their mother
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• at E10 the notochord in the trunk is poorly differentiated and characteristic of embryos inheriting the Thp allele from their father
• at E10 the notochord in the tail may be absent, swollen, or duplicated in embryos inheriting the Thp allele from their father
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• at E10 the tail notochord may be absent in embryos inheriting the Thp allele from their father
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cardiovascular system
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• inflation of the pericardium is seen in embryos inheriting the Thp allele from their mother
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nervous system
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• at E10 the neural tube of the tail region is often doubled or tripled in embryos inheriting the Thp allele from their mother
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• characteristic of some E10 embryos inheriting the Thp allele from their father
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• occurs at a low frequency among embryos inheriting the Thp allele from their mother
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• occurs in low frequency among embryos inheriting the Thp allele from their mother
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skeleton
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• may end abruptly before or at the level of the second sacral vertebra
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• characteristic of embryos inheriting the Thp allele from their father
• one or more may be incomplete dorsally
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• characteristic of embryos inheriting the Thp allele from their father
• frequently incomplete dorsally
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• characteristic of embryos inheriting the Thp allele from their father
• frequently incomplete dorsally
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cellular
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• heterozygous offspring from carrier females and normal males are edematous and die before or at birth
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Allelic
Composition |
Igf2rtm2Wag/Igf2r+
Del(17)Thp/+
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Genetic
Background |
involves: 129/Sv * 129P2/OlaHsd * AKR/J * C57BL/6 |
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mortality/aging
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• when is Igf2rtm2Wag inherited paternally and Thp is maternally, some mice survive birth and reach maturity despite some prenatal lethality
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• when the allele is inherited paternally, fewer than expected mice are born
• however, unlike when only Thp is inherited maternally, some mice are recovered at birth
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limbs/digits/tail
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• when is Igf2rtm2Wag inherited paternally and Thp is maternally, mice have a bent tail compared to wild-type mice
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reproductive system
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• when the allele is inherited paternally, mice are fertile
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(17)Thp mutation
(3 available);
any
Del(17)Thp mutation
(2 available)
Map3k4byg mutation
(0 available);
any
Map3k4 mutation
(77 available)
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XY embryos doubly heterozygous for Map3k4byg and Del(17)Thp exhibit a range of defects of gonad development similar to Map3k4byg homozygotes
reproductive system
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• testes exhibit regions lacking clear cord morphology unlike in wild-type mice
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• at E13.5 and E14.5, XY gonads exhibit disruption in cord morphology or gonadal sex reversal
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nervous system
endocrine/exocrine glands
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• testes exhibit regions lacking clear cord morphology unlike in wild-type mice
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embryo
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(17)Thp mutation
(3 available);
any
Del(17)Thp mutation
(2 available)
Map3k4C57BL/6J mutation
(0 available);
any
Map3k4 mutation
(77 available)
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reproductive system
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• Background Sensitivity: XY mice of his genotype develop ovaries and/or ovotestes on a C57BL/6 background containing a Y chromosome from the AKR inbred strain
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• Background Sensitivity: XY mice of this genotype may have an underdevloped scrotum and penis, and mammae-associated pigment which is normally a female characteristic
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• some hermaphrodites breed but sire fewer litters
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Analysis Tools