Phenotypes associated with this allele

• Allele Symbol: Scd1^ab-J
• Allele Name: asebia Jackson
• Allele ID: MGI:1855952
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scd1^ab-J/Scd1^ab-J	ABJ/LeJ-Scd1^ab-J	MGI:3794974
cx2	Ldlr^tm1Her/Ldlr^tm1Her Scd1^ab-J/Scd1^ab-J	B6.Cg-Ldlr^tm1Her Scd1^ab-J	MGI:3794981

Genotype
MGI:3794974

hm1

• Allelic Composition: Scd1^ab-J/Scd1^ab-J
• Genetic Background: ABJ/LeJ-Scd1^ab-J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

hunched posture ( J:62699 )

integument

integument phenotype ( J:62699 )

N • transepidermal water loss is normal

sparse hair ( J:62699 )

matted coat ( J:62699 )

abnormal skin morphology ( J:62699 )

• mice exhibit thicker than normal epidermis, Malphigian layer and stratum corneum that is not as thick as in Scd1^ab-2J homozygotes

thick dermal layer ( J:62699 )

• the dermis is thicker than in wild-type mice but not as thick as in Scd1^ab-2J homozygotes

hyperkeratosis ( J:62699 )

dry skin ( J:62699 )

flaky skin ( J:62699 )

scaly skin ( J:62699 )

Genotype
MGI:3794981

cx2

• Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her; Scd1^ab-J/Scd1^ab-J
• Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J

adipose tissue

abnormal fat pad morphology ( J:130278 )

abnormal epididymal fat pad morphology ( J:130278 )

• when fed a western style diet for 12 weeks, male mice have smaller periepididymal fat pads than Ldlr^tm1Her homozygotes

abnormal uterine fat pad morphology ( J:130278 )

• when fed a western style diet for 12 weeks, female mice have smaller periuterine fat pads than Ldlr^tm1Her homozygotes

decreased percent body fat/body weight ( J:130278 )

• when fed a western style diet for 12 weeks, mice exhibit a 50% reduction in total fat mass compared to in Ldlr^tm1Her homozygotes

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:130278 )

N • when fed a western style diet for 12 weeks, mice are protected from impaired glucose tolerance, hyperglycemia and increased plasma insulin levels observed in Ldlr^tm1Her homozygotes

abnormal lipid level ( J:130278 )

• when fed a western style diet for 12 weeks, mice exhibit a decrease in visceral and subcutaneous lipid compared to in Ldlr^tm1Her homozygotes

decreased circulating cholesterol level ( J:130278 )

• when fed a western style diet for 12 weeks, male mice exhibit a lower circulating cholesterol level than in Ldlr^tm1Her homozygotes

decreased circulating VLDL cholesterol level ( J:130278 )

• compared to in Ldlr^tm1Her homozygotes when fed a western style diet for 12 weeks

decreased circulating triglyceride level ( J:130278 )

• when fed a western style diet for 12 weeks, female mice exhibit a lower circulating triglyceride level than in Ldlr^tm1Her homozygotes

decreased circulating VLDL triglyceride level ( J:130278 )

• compared to in Ldlr^tm1Her homozygotes when fed a western style diet for 12 weeks

decreased liver triglyceride level ( J:130278 )

• when fed a western style diet for 12 weeks, mice exhibit a 5-fold lower hepatic triglyceride level than in Ldlr^tm1Her homozygotes

behavior/neurological

increased food intake ( J:130278 )

• when fed a western style diet for 12 weeks, mice consuming more food than Ldlr^tm1Her homozygotes

growth/size/body

slow postnatal weight gain ( J:130278 )

• when fed a western style diet for 12 weeks, mice gain less weight than Ldlr^tm1Her homozygotes despite consuming more food

liver/biliary system

liver/biliary system phenotype ( J:130278 )

N • when fed a western style diet for 12 weeks, mice are protected from the hepatic steatosis observed in Ldlr^tm1Her homozygotes

decreased liver triglyceride level ( J:130278 )

• when fed a western style diet for 12 weeks, mice exhibit a 5-fold lower hepatic triglyceride level than in Ldlr^tm1Her homozygotes