Del(18Pcdhg)6Tyag
Targeted Allele Detail

Summary

• Symbol: Del(18Pcdhg)6Tyag
• Name: deletion, Chr 18, Takeshi Yagi 6
• MGI ID: MGI:6331280
• Synonyms: Del(18Pcdhg)1Tyag, Del6Tyag, Pcdhg^del
• Gene: Del(18Pcdhg)6Tyag Location: unknown Genetic Position: Chr18, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244163
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Del(18Pcdhg)6Tyag involves 25 genes/genome features (Pcdhg, Slc25a2, Taf7 ...) View all
• Mutation details: This allele follows the meiotic cre-mediated recombination between the Pcdhb^tm2Tyag and Pcdhg^tm1.1Tyag alleles. The Pcdhb^tm2Tyag allele has a loxP and FRT site flanked neomycin resistance gene cassette inserted upstream of the first gene, Pcdhb1, in the cluster. The Pcdhg^tm1.1Tyag allele has an IRES, a lacZ gene cassette and a loxP site inserted into the 3' UTR of the last shared exon, gammaCR3, of the cluster genes. Recombination between the two results in the complete deletion of the Pcdhg cluster and the Slc25a2 and Taf7 genes located between Pcdhb and Pcdhg, as well as the inserted neo cassette and lacZ gene. (J:244163)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(18Pcdhg)6Tyag Mutation: 0 strains or lines available

References

• Original: J:244163 Hasegawa S, et al., Distinct and Cooperative Functions for the Protocadherin-alpha, -beta and -gamma Clusters in Neuronal Survival and Axon Targeting. Front Mol Neurosci. 2016;9:155
• All: 2 reference(s)