Del(2Duoxa2-Duoxa1)1Sref
Targeted Allele Detail

Summary

• Symbol: Del(2Duoxa2-Duoxa1)1Sref
• Name: deletion, Chr 2, Samuel Refetoff 1
• MGI ID: MGI:5544489
• Synonyms: Del1Sref, Duoxa^-, Duoxa1/Duoxa2^tm1.1Sref
• Gene: Del(2Duoxa2-Duoxa1)1Sref Location: unknown Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205329
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(2Duoxa2-Duoxa1)1Sref involves 2 genes/genome features (Duoxa2, Duoxa1) View all
• Mutation details: A self-excising neomycin resistance cassette replaced 2857 bp spanning between exon 5 of Duoxa2 to coding exon 5 of Duoxa1. The final allele lacks the neomycin resistance cassette. Mice lack DUOX-based NADPH oxidase activity. (J:205329)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(2Duoxa2-Duoxa1)1Sref Mutation: 0 strains or lines available

References

• Original: J:205329 Grasberger H, et al., Mice deficient in dual oxidase maturation factors are severely hypothyroid. Mol Endocrinol. 2012 Mar;26(3):481-92
• All: 11 reference(s)