Analysis Tools
mortality/aging
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• when weaned at P21
• however, some mice survive into adulthood when weaned at P30
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endocrine/exocrine glands
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• massive hypertrophy and hyperplasia of thyrotrophic cells
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• massive resulting in subglottic stenosis
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• diffuse and homogeneous with residual small follicles lined by columnar epithelium that frequently form papillary folds protruding into the lumen
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• mice lack thyroidal iodide organification
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homeostasis/metabolism
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• 500-fold in make mice and 2500-fold in female mice in mice fed standard chow or a low iodine diet
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• undetectable
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• however, L-T4 replacement normalizes levels
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skeleton
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• impaired linear growth
• however, L-T4 replacement normalizes bone growth
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hematopoietic system
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• however, L-T4 replacement normalizes spleen weight
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growth/size/body
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• at 2 weeks
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• severe
• however, L-T4 replacement normalizes weight gain
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behavior/neurological
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• mice fail to invert and climb down when placed on a vertical pole unlike wild-type mice
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• bilateral
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respiratory system
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• at 1 and 3 months, one third of mice develop signs of respiratory distress accompanied by an audible inspiratory stridor, unlike wild-type mice
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• at 1 and 3 months, one third of mice develop signs of respiratory distress accompanied by an audible inspiratory stridor, unlike wild-type mice
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vision/eye
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• 15.5 days instead of 12.2 days for wild-type mice
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immune system
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• however, L-T4 replacement normalizes spleen weight
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limbs/digits/tail
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• impaired linear growth
• however, L-T4 replacement normalizes bone growth
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nervous system
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• massive hypertrophy and hyperplasia of thyrotrophic cells
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• when normalized to body weight
• however, L-T4 replacement normalizes brain weight
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