Duoxa2 MGI Mouse Gene Detail - MGI:1914061 - dual oxidase maturation factor 2

Symbol

Duoxa2
Name

dual oxidase maturation factor 2
Synonyms

9030623N16Rik, Nip2

Feature Type

protein coding gene
IDs

MGI:1914061
NCBI Gene: 66811
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:122129381-122133088 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 60.62 cM, cytoband F1
Mapping Data

2 experiments

SNPs within 2kb

166 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914061	protein coding gene	Chr2:122129381-122133366 (+)
129S1/SvImJ	ENSMUSG00200042867	protein coding gene	Chr2:119065684-119069664 (+)
A/J	ENSMUSG00195024956	protein coding gene	Chr2:119105347-119109381 (+)
AKR/J	ENSMUSG00220042266	protein coding gene	Chr2:119022831-119026865 (+)
BALB/cJ	ENSMUSG00180036515	protein coding gene	Chr2:118906097-118910131 (+)
C3H/HeJ	ENSMUSG00175025324	protein coding gene	Chr2:119379980-119384014 (+)
C57BL/6NJ	ENSMUSG00215024694	protein coding gene	Chr2:119048231-119052217 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024211	protein coding gene	Chr2:115144918-115148891 (+)
CAST/EiJ	ENSTCUG00005016025	protein coding gene	Chr2:118312120-118316094 (+)
CBA/J	ENSMUSG00210007491	protein coding gene	Chr2:119220837-119224871 (+)
DBA/2J	ENSMUSG00185040863	protein coding gene	Chr2:118903192-118907226 (+)
FVB/NJ	ENSMUSG00205040092	protein coding gene	Chr2:118128479-118132462 (+)
JF1/MsJ	ENSUMUG00000012207	protein coding gene	Chr2:118796516-118800501 (+)
LP/J	ENSMUSG00230019614	protein coding gene	Chr2:120725197-120729183 (+)
NOD/ShiLtJ	ENSMUSG00190038358	protein coding gene	Chr2:119152595-119156577 (+)
NZO/HlLtJ	ENSMUSG00225003299	protein coding gene	Chr2:128627459-128631496 (+)
PWK/PhJ	ENSLUMG00010045867	protein coding gene	Chr2:118733579-118737570 (+)
SPRET/EiJ	ENSMSPG00010043551	protein coding gene	Chr2:121129393-121133140 (+)
WSB/EiJ	ENSIUOG00005021842	protein coding gene	Chr2:118875894-118879868 (+)

Human Ortholog

DUOXA2, dual oxidase maturation factor 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DUOXA2, dual oxidase maturation factor 2
Synonyms

SIMNIPHOM, TDH5
Links

HGNC:32698

NCBI Gene ID: 405753

UniProt: Q1HG44
Chr Location

15q21.1; chr15:45114325-45118421 (+) GRCh38

MGI Vertebrate Homology

Duoxa2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DUOXA2
Gene Tree

Duoxa2

Diseases

1 with human DUOXA2 associations

				Human Disease	Mouse Models
				thyroid dyshormonogenesis 5 IDs thyroid dyshormonogenesis 5 DOID:0112184 MESH:C562771 OMIM:274900

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

78 phenotypes from 1 allele in 1 genetic background
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

5
Radiation induced

1
Targeted

3
Genomic Mutations

3 involving Duoxa2
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele of Duoxa1 and 2 exhibit severe hypothyrodism with severe postnatal growth, delayed eye opening, enlarged thyroid, enlarged adenohypophysis, respiratory distress and death at weaning when weaned at 21 days.

less

All GO Annotations

46
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

608
Tissues

11
cDNA Data

7
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

30
RefSeq

2
UniProt

1
CCDS

CCDS16660.1

Ensembl

ENSMUSG00000027225 (Evidence)
NCBI Gene

66811

			Length	Strain/Species	Flank
genomic	66811	NCBI Gene Model \| MGI Sequence Detail	3708	C57BL/6J	± kb
transcript	NM_025777	RefSeq \| MGI Sequence Detail	1314	C57BL/6
polypeptide	Q9D311	UniProt \| EBI \| MGI Sequence Detail	320	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000006730 dual oxidase maturation factor 2

(term hierarchy)
InterPro Domains

IPR018469 Dual oxidase maturation factor
GlyGen

Q9D311 3 sites

less

All nucleic 8

cDNA 7

Primer pair 1

Microarray probesets 3

Summaries

All 58

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 26
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:375726 Singh AK, et al., De novo DUOX2 expression in neutrophil subsets shapes the pathogenesis of intestinal disease. Proc Natl Acad Sci U S A. 2025 May 13;122(19):e2421747122

TSS for Duoxa2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19840	Chr2:122129379-122129384 (+)	1 bp
Tssr19841	Chr2:122131612-122131631 (+)	2,241 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24