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C4a Gene Detail
Summary
  • Symbol
    C4a
  • Name
    complement C4A
  • Synonyms
    Slp
  • Feature Type
    protein coding gene
  • IDs
    MGI:98320
    NCBI Gene: 625018
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35028069-35042436 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.37 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • Strain Annotations
    35
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98320
 protein coding gene Chr17:35028069-35042440 (-)
129S1/SvImJ ENSMUSG00200051966
 lncRNA gene Chr17:30731244-30745617 (-)
A/J ENSMUSG00195046430
 lncRNA gene Chr17:31631444-31645813 (-)
A/J ENSMUSG00195036502
 protein coding gene Chr17:31631549-31645754 (-)
AKR/J ENSMUSG00220052648
 lncRNA gene Chr17:30660080-30674438 (-)
AKR/J ENSMUSG00220041061
 protein coding gene Chr17:30660185-30674379 (-)
BALB/cJ ENSMUSG00180035877
 protein coding gene Chr17:31001417-31015622 (-)
BALB/cJ ENSMUSG00180044589
 lncRNA gene Chr17:31001312-31015681 (-)
C3H/HeJ ENSMUSG00175029672
 protein coding gene Chr17:30546293-30560487 (-)
C3H/HeJ ENSMUSG00175042632
 lncRNA gene Chr17:30546188-30560546 (-)
C57BL/6NJ ENSMUSG00215053475
 lncRNA gene Chr17:30571431-30585804 (-)
C57BL/6NJ ENSMUSG00215047571
 protein coding gene Chr17:30571536-30585745 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013483
 unclassified non-coding RNA gene Chr17:31527032-31542709 (-)
CAST/EiJ ENSTCUG00005051691
 lncRNA gene Chr17:31589635-31604015 (-)
CAST/EiJ ENSTCUG00005041907
 protein coding gene Chr17:31589740-31603956 (-)
CBA/J ENSMUSG00210049182
 protein coding gene Chr17:30368401-30382595 (-)
CBA/J ENSMUSG00210052315
 lncRNA gene Chr17:30368296-30382654 (-)
DBA/2J ENSMUSG00185055596
 lncRNA gene Chr17:33020578-33034947 (-)
DBA/2J ENSMUSG00185046409
 protein coding gene Chr17:33020683-33034888 (-)
FVB/NJ ENSMUSG00205043524
 protein coding gene Chr17:30890107-30904314 (-)
FVB/NJ ENSMUSG00205053833
 lncRNA gene Chr17:30890002-30904373 (-)
JF1/MsJ ENSUMUG00000053352
 protein coding gene Chr17:32273140-32287332 (-)
JF1/MsJ ENSUMUG00000057411
 lncRNA gene Chr17:32273035-32287391 (-)
LP/J ENSMUSG00230054591
 protein coding gene Chr17:34129617-34143825 (-)
LP/J ENSMUSG00230054777
 lncRNA gene Chr17:34129512-34143884 (-)
NOD/ShiLtJ ENSMUSG00190044892
 protein coding gene Chr17:30491092-30505284 (-)
NOD/ShiLtJ ENSMUSG00190053377
 lncRNA gene Chr17:30490987-30505343 (-)
NZO/HlLtJ ENSMUSG00225053589
 protein coding gene Chr17:36142603-36156806 (-)
NZO/HlLtJ ENSMUSG00225054886
 lncRNA gene Chr17:36142498-36156865 (-)
PWK/PhJ ENSLUMG00010053451
 lncRNA gene Chr17:30100258-30114604 (-)
PWK/PhJ ENSLUMG00010047238
 protein coding gene Chr17:30100363-30114545 (-)
SPRET/EiJ ENSMSPG00010050460
 lncRNA gene Chr17:31293189-31307534 (-)
SPRET/EiJ ENSMSPG00010043266
 protein coding gene Chr17:31293294-31307474 (-)
WSB/EiJ ENSIUOG00005050210
 protein coding gene Chr17:31218923-31233131 (-)
WSB/EiJ ENSIUOG00005051705
 lncRNA gene Chr17:31218818-31233190 (-)



Homology
more
  • Human Ortholog
    C4A, complement C4A (Chido/Rodgers blood group)
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    C4A, complement C4A (Chido/Rodgers blood group)
  • Synonyms
    C4, C4A2, C4A3, C4A4, C4A6, C4AD, C4S, CO4, CPAMD2, RG
  • Links
    NCBI Gene ID: 720
    UniProt: P0C0L4

  • Chr Location
    6p21.33; chr6:31981991-32004877 (+)  GRCh38
  • Human Ortholog
    C4B, complement C4B (Chido/Rodgers blood group)
  • Synonyms
    C4B1, C4B12, C4B3, C4B5, C4BD, C4F, CH, CO4, CPAMD3
  • Links
    NCBI Gene ID: 721
    UniProt: P0C0L5

  • Chr Location
    6p21.33; chr6:32014730-32035973 (+)  GRCh38
Human Diseases
more
  • Diseases
    8 with human C4A,C4B associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
 View 1 model
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    7
Sequences &
Gene Models
less
  • All Sequences
    77
  • RefSeq
    3
  • UniProt
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic 625018 NCBI Gene Model | MGI Sequence Detail 14368 C57BL/6J ±  kb
transcript NM_011413 RefSeq | MGI Sequence Detail 5369 Not Specified  
polypeptide A0AAQ4VMX2 UniProt | EBI | MGI Sequence Detail 1734 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 87
    Genomic 71
    cDNA 14
    Other 2
    Antibodies 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-14443
References
more
  • Summaries
    All 88
    Gene Ontology 8
    Phenotypes 6
  • Earliest
    J:5181 Passmore HC, et al., A sex-limited serum protein variant in the mouse: inheritance and association with the H-2 region. Biochem Genet. 1970 Jun;4(3):351-65
  • Latest
    J:387588 Graves LE, et al., Targeted editing of the 21-hydroxylase locus confers durable therapeutic effect in a murine model of congenital adrenal hyperplasia. Mol Ther. 2026 Feb 4;34(2):1138-1151
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory