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Xpr1 Gene Detail
Summary
  • Symbol
    Xpr1
  • Name
    xenotropic and polytropic retrovirus receptor 1
  • Synonyms
    Rmc-1, Rmc1, suppressor of yeast Ga deletion, Syg1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97932
    NCBI Gene: 19775
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:155151447-155293161 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 66.49 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2684 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97932
 protein coding gene Chr1:155151403-155293190 (-)
129S1/SvImJ ENSMUSG00200002539
 protein coding gene Chr1:152594312-152736054 (-)
A/J ENSMUSG00195013957
 protein coding gene Chr1:151982357-152124113 (-)
AKR/J ENSMUSG00220005020
 protein coding gene Chr1:151781560-151923314 (-)
BALB/cJ ENSMUSG00180030583
 protein coding gene Chr1:152201618-152343306 (-)
C3H/HeJ ENSMUSG00175002607
 protein coding gene Chr1:152240789-152387835 (-)
C57BL/6NJ ENSMUSG00215003438
 protein coding gene Chr1:152137302-152279071 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014725
 protein coding gene Chr1:145983945-146128756 (-)
CAST/EiJ ENSTCUG00005005460
 protein coding gene Chr1:150786114-150926656 (-)
CBA/J ENSMUSG00210031822
 protein coding gene Chr1:152144197-152285916 (-)
DBA/2J ENSMUSG00185040846
 protein coding gene Chr1:156420854-156562564 (-)
FVB/NJ ENSMUSG00205017838
 protein coding gene Chr1:151276550-151418281 (-)
JF1/MsJ ENSUMUG00000007319
 protein coding gene Chr1:155577328-155713677 (-)
LP/J ENSMUSG00230015312
 protein coding gene Chr1:155978834-156120127 (-)
NOD/ShiLtJ ENSMUSG00190012246
 protein coding gene Chr1:151992366-152134067 (-)
NZO/HlLtJ ENSMUSG00225004870
 protein coding gene Chr1:159657472-159799199 (-)
PWK/PhJ ENSLUMG00010027050
 protein coding gene Chr1:150928529-151072939 (-)
SPRET/EiJ ENSMSPG00010039155
 protein coding gene Chr1:154274107-154407543 (-)
WSB/EiJ ENSIUOG00005021948
 protein coding gene Chr1:151560569-151703883 (-)



Homology
more
  • Human Ortholog
    XPR1, xenotropic and polytropic retrovirus receptor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    XPR1, xenotropic and polytropic retrovirus receptor 1
  • Synonyms
    IBGC6, SLC53A1, SYG1, X3
  • Links
    NCBI Gene ID: 9213
    UniProt: Q9UBH6

  • Chr Location
    1q25.3; chr1:180632016-180890279 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human XPR1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes and heterozygotes for a variant from some wild Mus stocks, including M. spretus, support replication of xenotropic murine leukemia viruses and mink cell focus-forming murine leukemia viruses that are not replicated in most laboratory strains.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    29
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    43
  • cDNA Data
    21
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026469 Ensembl Gene Model | MGI Sequence Detail 141715 C57BL/6J ±  kb
transcript ENSMUST00000027741 Ensembl | MGI Sequence Detail 7492 Not Applicable  
polypeptide ENSMUSP00000027741 Ensembl | MGI Sequence Detail 695 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 33
    Genomic 4
    cDNA 26
    Primer pair 2
    Other 1
    Antibodies 1

    Microarray probesets 9
Other
Accession IDs
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MGD-MRK-13898, MGD-MRK-13899, MGD-MRK-14673
References
more
  • Summaries
    All 63
    Developmental Gene Expression 7
    Gene Ontology 8
    Phenotypes 16
  • Earliest
    J:7177 Kozak CA, Genetic mapping of a mouse chromosomal locus required for mink cell focus-forming virus replication. J Virol. 1983 Oct;48(1):300-3
  • Latest
    J:375985 Stifter SA, et al., XPR1 regulates fetal liver macrophage development, identity, and pyrenocyte clearance. J Exp Med. 2026 Feb 2;223(2)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory