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Ppia Gene Detail
Summary
  • Symbol
    Ppia
  • Name
    peptidylprolyl isomerase A
  • Synonyms
    Cphn, cyclophilin A, CyP-18, CypA
  • Feature Type
    protein coding gene
  • IDs
    MGI:97749
    NCBI Gene: 268373
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:6365867-6369817 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 3.97 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    144 from dbSNP Build 142
  • Strain Annotations
    32
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97749
 protein coding gene Chr11:6365443-6369817 (+)
129S1/SvImJ ENSMUSG00200032043
 protein coding gene Chr11:3307338-3311712 (+)
129S1/SvImJ ENSMUSG00200024780
 protein coding gene Chr3:118736243-119125879 (+)
A/J ENSMUSG00195020682
 protein coding gene Chr11:3230954-3235329 (+)
A/J ENSMUSG00195016931
 protein coding gene Chr9:93157243-93158053 (+)
A/J ENSMUSG00195015262
 protein coding gene Chr3:118953344-118954139 (+)
AKR/J ENSMUSG00220024156
 protein coding gene Chr3:117340343-117341139 (+)
AKR/J ENSMUSG00220028924
 protein coding gene Chr13:10897959-10898744 (+)
AKR/J ENSMUSG00220007638
 protein coding gene Chr11:3260278-3264654 (+)
BALB/cJ no annotation
C3H/HeJ ENSMUSG00175011981
 protein coding gene Chr9:93817179-93817989 (+)
C3H/HeJ ENSMUSG00175025517
 protein coding gene Chr3:118436626-118437421 (+)
C3H/HeJ ENSMUSG00175009747
 protein coding gene Chr11:3234127-3238501 (+)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0016073
 protein coding gene Chr11:3273308-3276720 (+)
CAST/EiJ ENSTCUG00005035510
 protein coding gene Chr11:3319261-3323637 (+)
CBA/J ENSMUSG00210014796
 protein coding gene Chr9:93659216-93660026 (+)
CBA/J ENSMUSG00210002824
 protein coding gene Chr3:119067557-119068352 (+)
CBA/J ENSMUSG00210017791
 protein coding gene Chr11:3243789-3248163 (+)
DBA/2J ENSMUSG00185010772
 protein coding gene Chr9:93845348-93846158 (+)
DBA/2J ENSMUSG00185006980
 protein coding gene Chr3:119632915-119633709 (+)
DBA/2J ENSMUSG00185016723
 protein coding gene Chr11:3341569-3345943 (+)
FVB/NJ ENSMUSG00205019323
 protein coding gene Chr9:93850175-93850985 (+)
FVB/NJ ENSMUSG00205017251
 protein coding gene Chr11:3214785-3219159 (+)
FVB/NJ ENSMUSG00205006916
 protein coding gene Chr3:118004347-118005143 (+)
JF1/MsJ no annotation
LP/J no annotation
NOD/ShiLtJ ENSMUSG00190026731
 protein coding gene Chr3:120015410-120016206 (+)
NOD/ShiLtJ ENSMUSG00190010685
 protein coding gene Chr2:80415159-80415816 (+)
NOD/ShiLtJ ENSMUSG00190038321
 protein coding gene Chr11:3223455-3227830 (+)
NZO/HlLtJ ENSMUSG00225002675
 protein coding gene Chr3:124074331-124075127 (+)
NZO/HlLtJ ENSMUSG00225025610
 protein coding gene Chr11:6446435-6450809 (+)
NZO/HlLtJ ENSMUSG00225000403
 protein coding gene Chr2:58416018-58416771 (-)
PWK/PhJ ENSLUMG00010018249
 protein coding gene Chr11:3234744-3239118 (+)
SPRET/EiJ ENSMSPG00010007846
 protein coding gene Chr11:3292828-3297374 (+)
WSB/EiJ ENSIUOG00005006771
 protein coding gene Chr11:3246998-3251372 (+)



Homology
more
  • Human Ortholog
    PPIA, peptidylprolyl isomerase A
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPIA, peptidylprolyl isomerase A
  • Synonyms
    CYPA, CYPH, HEL-S-69p
  • Links
    NCBI Gene ID: 5478
    UniProt: P62937

  • Chr Location
    7p13; chr7:44796678-44824564 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PPIA associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 2 alleles in 3 genetic backgrounds
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene tend to develop blepharitis (about 30% of mice) as well as inflammation in other organs. Some background dependent embryonic lethality occurs but adults are robust and live normal life spans.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    73
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    662
  • Tissues
    36
  • cDNA Data
    35
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 268373 NCBI Gene Model | MGI Sequence Detail 3951 C57BL/6J ±  kb
    transcript NM_008907 RefSeq | MGI Sequence Detail 746 ZRU/MplStud  
    polypeptide P17742 UniProt | EBI | MGI Sequence Detail 164 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000013075 peptidyl-prolyl cis-trans isomerase A
      (term hierarchy)
    • PDB
      6FK1
    • EC
      5.2.1.8
    • InterPro Domains
      IPR029000 Cyclophilin-like domain superfamily
      IPR024936 Cyclophilin-type peptidyl-prolyl cis-trans isomerase
      IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
      IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
    • GlyGen
      P17742 3 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 36
      Primer pair 10

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-13591, MGD-MRK-2108
    References
    more
    • Summaries
      All 135
      Developmental Gene Expression 20
      Gene Ontology 15
      Phenotypes 42
    • Earliest
      J:154091 Gogstad GO, et al., Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa. Biochim Biophys Acta. 1981 Sep 29;670(2):150-62
    • Latest
      J:377160 Baikova IP, et al., High Blood Levels of Cyclophilin A Increased Susceptibility to Ulcerative Colitis in a Transgenic Mouse Model. Int J Mol Sci. 2025 Dec 15;26(24)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory