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Mif Gene Detail
Summary
  • Symbol
    Mif
  • Name
    macrophage migration inhibitory factor (glycosylation-inhibiting factor)
  • Synonyms
    Glif
  • Feature Type
    protein coding gene
  • IDs
    MGI:96982
    NCBI Gene: 17319
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:75695187-75696074 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 38.59 cM, cytoband C1
  • Mapping Data
    18 experiments
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    22
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96982
 protein coding gene Chr10:75695187-75696111 (-)
129S1/SvImJ ENSMUSG00200045776
 protein coding gene Chr10:72396698-72397585 (-)
129S1/SvImJ ENSMUSG00200043184
 protein coding gene Chr7:19443335-19443887 (-)
A/J ENSMUSG00195047544
 protein coding gene Chr10:72708836-72709723 (-)
AKR/J ENSMUSG00220041477
 protein coding gene Chr2:118717258-118718209 (+)
AKR/J ENSMUSG00220043683
 protein coding gene Chr10:72368579-72369466 (-)
BALB/cJ ENSMUSG00180052746
 protein coding gene Chr10:72723300-72724187 (-)
C3H/HeJ ENSMUSG00175041683
 protein coding gene Chr10:72594630-72595517 (-)
C57BL/6NJ ENSMUSG00215051505
 protein coding gene Chr10:72332226-72333113 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015453
 protein coding gene Chr10:69898336-69899231 (-)
CAST/EiJ ENSTCUG00005048499
 protein coding gene Chr10:72208026-72208914 (-)
CBA/J ENSMUSG00210043409
 protein coding gene Chr10:72450806-72451693 (-)
DBA/2J ENSMUSG00185050396
 protein coding gene Chr10:72793093-72793981 (-)
FVB/NJ ENSMUSG00205026361
 protein coding gene Chr10:72486113-72487000 (-)
FVB/NJ ENSMUSG00205026887
 protein coding gene Chr2:117817623-117818574 (+)
JF1/MsJ ENSUMUG00000055547
 protein coding gene Chr10:73940957-73941850 (-)
LP/J ENSMUSG00230047803
 protein coding gene Chr10:74562690-74563577 (-)
NOD/ShiLtJ ENSMUSG00190046736
 protein coding gene Chr10:72770622-72771509 (-)
NZO/HlLtJ ENSMUSG00225015000
 protein coding gene Chr6:129349429-129349949 (+)
NZO/HlLtJ ENSMUSG00225045745
 protein coding gene Chr10:78859170-78860057 (-)
PWK/PhJ ENSLUMG00010051339
 protein coding gene Chr10:72335858-72336749 (-)
SPRET/EiJ ENSMSPG00010045035
 protein coding gene Chr10:74125721-74127532 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    MIF, macrophage migration inhibitory factor
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIF, macrophage migration inhibitory factor
  • Synonyms
    GIF, GLIF, MMIF
  • Links
    NCBI Gene ID: 4282
    UniProt: P14174

  • Chr Location
    22q11.23; chr22:23894372-23895227 (+)  GRCh38
Human Diseases
more
  • Diseases
    8 with human MIF associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 4 alleles in 6 genetic backgrounds
    2 images
    162 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for three distinct targeted alleles show varying immune system defects. Among these are increased endotoxin resistance and Pseudomonas clearance; reduced size of induced fibrosarcomas and lower mitotic index; and decreased contact hypersensitivity. A specific point mutation that blocks the peptide's nuclease activity blocks it's apoptotic activity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    100
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    991
  • Tissues
    308
  • cDNA Data
    18
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033307 Ensembl Gene Model | MGI Sequence Detail 888 C57BL/6J ±  kb
    transcript ENSMUST00000038169 Ensembl | MGI Sequence Detail 544 Not Applicable  
    polypeptide ENSMUSP00000041149 Ensembl | MGI Sequence Detail 115 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 11
      cDNA 21
      Primer pair 2
      Other 2
      Antibodies 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-12232, MGD-MRK-16214, MGI:99446
    References
    more
    • Summaries
      All 303
      Developmental Gene Expression 19
      Gene Ontology 23
      Phenotypes 162
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:386197 Mace JW, et al., Autoimmune neuroinflammation leads to neuronal death via MIF nuclease-mediated parthanatos. Nat Neurosci. 2026 Apr;29(4):796-809
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory