Mif Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mif
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MGI:96982

21 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mif^tm1Dvd/Mif^tm1Dvd B6.129S4-Mif^tm1Dvd	decreased incidence of tumors by chemical induction	J:126543
Mif^tm1Dvd/Mif^tm1Dvd involves: 129S4/SvJae * C57BL/6	decreased circulating tumor necrosis factor level	J:52300
	decreased susceptibility to bacterial infection	J:52300
	decreased susceptibility to endotoxin shock	J:52300
	increased interleukin-4 secretion	J:52300
	increased myocardial infarct size	J:213776
	increased susceptibility to myocardial ischemic injury	J:213776
	increased susceptibility to parasitic infection	J:52300
Mif^tm1Gfr/Mif^tm1Gfr C57BL/6-Mif^tm1Gfr	decreased fibroblast proliferation	J:147772
	decreased mitotic index	J:84791
	increased fibrosarcoma incidence	J:84791
	increased incidence of tumors by chemical induction	J:147772
Mif^tm1Mky/Mif^tm1Mky C.129-Mif^tm1Mky	abnormal cochlear ganglion morphology	J:215898
	abnormal cytokine secretion	J:106380
	abnormal inflammatory response	J:106380
	abnormal outer hair cell stereociliary bundle morphology	J:215898
	decreased cochlear outer hair cell number	J:215898
	decreased eosinophil cell number	J:106380
	impaired hearing	J:215898
	increased or absent threshold for auditory brainstem response	J:215898
Mif^tm1Mky/Mif^tm1Mky either: (involves: 129S1/Sv * 129X1/SvJ * BALB/c) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	no abnormal phenotype detected	J:75496
Mif^tm2Gfr/Mif^tm2Gfr C57BL/6-Mif^tm2Gfr	decreased fibroblast proliferation	J:147772
Mif^tm2Gfr/Mif^tm2Gfr C57BL/6-Mif^tm2Gfr	increased incidence of tumors by chemical induction	J:147772

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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