Mif^tm1Gfr
Targeted Allele Detail

Summary

• Symbol: Mif^tm1Gfr
• Name: macrophage migration inhibitory factor (glycosylation-inhibiting factor); targeted mutation 1, G Fingerle-Rowson
• MGI ID: MGI:2673280
• Synonyms: MIF^-
• Gene: Mif Location: Chr10:75695187-75696074 bp, - strand Genetic Position: Chr10, 38.59 cM, cytoband C1
• Alliance: Mif^tm1Gfr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84791
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The endogenous locus was replaced with a single loxP site after the transient expression of cre recombinase in ES cells deleted sequence encompassing (from 5' to 3') the 3' end of a nonfunctional retrotransposon of the intracisternalA particle (IAP), the promoter, and exons 1 through 3. Neither transcript nor protein was detected in homozygous mutant mice by Northern and Western blot analyses. (J:84791)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Mif^tm1Gfr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mif Mutation: 21 strains or lines available

References

• Original: J:84791 Fingerle-Rowson G, et al., The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9354-9
• All: 59 reference(s)