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Itk Gene Detail
Summary
  • Symbol
    Itk
  • Name
    IL2 inducible T cell kinase
  • Synonyms
    Emt, Tcsk, Tsk
  • Feature Type
    protein coding gene
  • IDs
    MGI:96621
    NCBI Gene: 16428
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:46215977-46280342 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 27.75 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2247 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96621
 protein coding gene Chr11:46215975-46280342 (-)
129S1/SvImJ ENSMUSG00200038151
 protein coding gene Chr11:43283329-43347451 (-)
A/J ENSMUSG00195029847
 protein coding gene Chr11:43227392-43291517 (-)
AKR/J ENSMUSG00220037948
 protein coding gene Chr11:43411905-43476329 (-)
BALB/cJ ENSMUSG00180030322
 protein coding gene Chr11:43217186-43281304 (-)
C3H/HeJ ENSMUSG00175033677
 protein coding gene Chr11:43220799-43284915 (-)
C57BL/6NJ ENSMUSG00215031232
 protein coding gene Chr11:43165185-43229562 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016242
 protein coding gene Chr11:41480708-41547004 (-)
CAST/EiJ ENSTCUG00005040780
 protein coding gene Chr11:42959510-43023503 (-)
CBA/J ENSMUSG00210028185
 protein coding gene Chr11:43110687-43174806 (-)
DBA/2J ENSMUSG00185025407
 protein coding gene Chr11:43286832-43350946 (-)
FVB/NJ ENSMUSG00205025724
 protein coding gene Chr11:43220482-43284887 (-)
JF1/MsJ ENSUMUG00000021171
 protein coding gene Chr11:43551141-43616869 (-)
LP/J ENSMUSG00230028963
 protein coding gene Chr11:44437071-44501185 (-)
NOD/ShiLtJ ENSMUSG00190039078
 protein coding gene Chr11:43327315-43391426 (-)
NZO/HlLtJ ENSMUSG00225035924
 protein coding gene Chr11:46385500-46449970 (-)
PWK/PhJ ENSLUMG00010028476
 protein coding gene Chr11:43109276-43173352 (-)
SPRET/EiJ ENSMSPG00010016302
 protein coding gene Chr11:43733395-43798708 (-)
WSB/EiJ ENSIUOG00005034279
 protein coding gene Chr11:43109336-43173677 (-)



Homology
more
  • Human Ortholog
    ITK, IL2 inducible T cell kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITK, IL2 inducible T cell kinase
  • Synonyms
    EMT, LPFS1, LYK, PSCTK2
  • Links
    NCBI Gene ID: 3702
    UniProt: Q08881

  • Chr Location
    5q33.3; chr5:157142933-157255185 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ITK associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 6 alleles in 11 genetic backgrounds
    34 phenotypes from multigenic genotypes
    92 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display decreased percentages of CD4 and CD8 cells, increased percentage of B cells, impaired T cell receptor signaling, and increased susceptibility to Toxoplasma gondii infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    17
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020395 Ensembl Gene Model | MGI Sequence Detail 64366 C57BL/6J ±  kb
    transcript ENSMUST00000109237 Ensembl | MGI Sequence Detail 4268 Not Applicable  
    polypeptide ENSMUSP00000104860 Ensembl | MGI Sequence Detail 625 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 2
      cDNA 21
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11504, MGD-MRK-14937
    References
    more
    • Summaries
      All 155
      Developmental Gene Expression 1
      Gene Ontology 17
      Phenotypes 92
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:370553 Imbiakha B, et al., Adaptive immune cells are necessary for SARS-CoV-2-induced pathology. Sci Adv. 2024 Jan 5;10(1):eadg5461
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory