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Il2rg Gene Detail
Summary
  • Symbol
    Il2rg
  • Name
    interleukin 2 receptor, gamma chain
  • Synonyms
    CD132, common cytokine receptor gamma chain, common gamma chain, gamma(c), gammaC, gamma C receptor, [g]c, gc
  • Feature Type
    protein coding gene
  • IDs
    MGI:96551
    NCBI Gene: 16186
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:100307991-100311861 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 43.90 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    90 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96551
 protein coding gene ChrX:100307984-100311861 (-)
129S1/SvImJ ENSMUSG00200037368
 protein coding gene ChrX:82021219-82025097 (-)
A/J ENSMUSG00195036115
 protein coding gene ChrX:85776029-85779906 (-)
AKR/J ENSMUSG00220025917
 protein coding gene ChrX:80466711-80470577 (-)
BALB/cJ ENSMUSG00180040518
 protein coding gene ChrX:82486374-82490253 (-)
C3H/HeJ ENSMUSG00175041984
 protein coding gene ChrX:86146806-86150683 (-)
C57BL/6NJ ENSMUSG00215045390
 protein coding gene ChrX:82676983-82680862 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033283
 protein coding gene ChrX:95523734-95527687 (-)
CAST/EiJ ENSTCUG00005038749
 protein coding gene ChrX:83525864-83529742 (-)
CBA/J ENSMUSG00210037598
 protein coding gene ChrX:82917663-82921540 (-)
DBA/2J ENSMUSG00185040375
 protein coding gene ChrX:95360692-95364570 (-)
FVB/NJ ENSMUSG00205024038
 protein coding gene ChrX:82175273-82179150 (-)
JF1/MsJ ENSUMUG00000027997
 protein coding gene ChrX:115942066-115945918 (-)
LP/J ENSMUSG00230042144
 protein coding gene ChrX:102054761-102058638 (-)
NOD/ShiLtJ ENSMUSG00190031604
 protein coding gene ChrX:82072527-82076406 (-)
NZO/HlLtJ ENSMUSG00225045442
 protein coding gene ChrX:107148584-107152459 (-)
PWK/PhJ ENSLUMG00010037402
 protein coding gene ChrX:81215080-81218948 (-)
SPRET/EiJ ENSMSPG00010034910
 protein coding gene ChrX:85522329-85526149 (-)
WSB/EiJ ENSIUOG00005041024
 protein coding gene ChrX:82608030-82611905 (-)



Homology
more
  • Human Ortholog
    IL2RG, interleukin 2 receptor subunit gamma
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL2RG, interleukin 2 receptor subunit gamma
  • Synonyms
    CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1
  • Links
    NCBI Gene ID: 3561
    UniProt: P31785

  • Chr Location
    Xq13.1; chrX:71107404-71112108 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human IL2RG associations

Human Disease Mouse Models
      
IDs
 View 3 "NOT" models
IDs
IDs
 View 3 "NOT" models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    82 phenotypes from 7 alleles in 9 genetic backgrounds
    54 phenotypes from multigenic genotypes
    1132 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males hemizygous for targeted null mutations exhibit markedly reduced numbers of T and B cells, lack NK cells and Peyer's patches, and have severely reduced numbers of gut-associated intraepithelial lymphocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • Tissues
    58
  • cDNA Data
    77
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16186 NCBI Gene Model | MGI Sequence Detail 3871 C57BL/6J ±  kb
    transcript NM_013563 RefSeq | MGI Sequence Detail 1663 ZRU/MplStud  
    polypeptide P34902 UniProt | EBI | MGI Sequence Detail 369 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 86
      Genomic 5
      cDNA 77
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11378
    References
    more
    • Summaries
      All 1262
      Developmental Gene Expression 10
      Diseases 2
      Gene Ontology 13
      Phenotypes 1132
    • Earliest
      J:12198 Kumaki S, et al., Cloning of the mouse interleukin 2 receptor gamma chain: demonstration of functional differences between the mouse and human receptors. Biochem Biophys Res Commun. 1993 May 28;193(1):356-63
    • Latest
      J:391672 Foidart P, et al., Whole-genome doubling drives immune evasion by silencing antigen presentation. Cancer Cell. 2026 Jul 13;44(7):1418-1436.e12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory