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Jchain Gene Detail
Summary
  • Symbol
    Jchain
  • Name
    immunoglobulin joining chain
  • Synonyms
    9530090F24Rik, Igj, Jch, J chain
  • Feature Type
    protein coding gene
  • IDs
    MGI:96493
    NCBI Gene: 16069
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:88667663-88675667 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 43.70 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    314 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96493
 protein coding gene Chr5:88667663-88675750 (-)
129S1/SvImJ ENSMUSG00200007567
 protein coding gene Chr5:84397187-84442174 (-)
A/J ENSMUSG00195025072
 protein coding gene Chr5:83570026-83615212 (-)
AKR/J ENSMUSG00220010756
 protein coding gene Chr5:83713103-83758290 (-)
BALB/cJ ENSMUSG00180023653
 protein coding gene Chr5:83396729-83441935 (-)
C3H/HeJ ENSMUSG00175039095
 protein coding gene Chr5:85483127-85533742 (-)
C57BL/6NJ ENSMUSG00215028396
 protein coding gene Chr5:84263067-84308038 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027374
 protein coding gene Chr5:81799121-81807176 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210005808
 protein coding gene Chr5:84291940-84337144 (-)
DBA/2J ENSMUSG00185038551
 protein coding gene Chr5:86206363-86251560 (-)
FVB/NJ ENSMUSG00205018353
 protein coding gene Chr5:83108295-83152295 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230001184
 protein coding gene Chr5:90923694-90968681 (-)
NOD/ShiLtJ ENSMUSG00190027514
 protein coding gene Chr5:83155916-83205465 (-)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    JCHAIN, joining chain of multimeric IgA and IgM
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    JCHAIN, joining chain of multimeric IgA and IgM
  • Synonyms
    IGCJ, IGJ, JCH
  • Links
    NCBI Gene ID: 3512
    UniProt: P01591

  • Chr Location
    4q13.3; chr4:70655541-70681817 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    9 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show increased IgA level and alterations in IgA transport and in susceptibility to viral and parasitic infections. Homozygotes for another null allele show increased IgA level, decreased IgM level, reduced numbers of IgM plasma cells, and impaired IgM immune responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    636
  • Tissues
    14
  • cDNA Data
    111
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16069 NCBI Gene Model | MGI Sequence Detail 8005 C57BL/6J ±  kb
    transcript NM_152839 RefSeq | MGI Sequence Detail 2018 C57BL/6  
    polypeptide P01592 UniProt | EBI | MGI Sequence Detail 159 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 113
      cDNA 111
      Primer pair 2
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11291, MGI:1915537, MGI:2140835
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 30
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:391651 Zhu Y, et al., Fasting impairs humoral immunological memory by beta-hydroxybutyrate-mediated depletion of plasma cells. Immunity. 2026 Feb 23;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory