Jchain Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Jchain
immunoglobulin joining chain
MGI:96493

9 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Jchain^Mat1/? Miju^C3HeB/FeJ/Miju^C57BL/6J involves: C3HeB/FeJ * C57BL/6J	increased IgA level	J:91062
Jchain^tm1Tl/Jchain^tm1Tl involves: 129P2/OlaHsd * BALB/cJ * C57BL/6	abnormal humoral immune response	J:71355
	decreased IgG level	J:71355
	decreased IgM level	J:71355
	increased IgA level	J:71355
Jchain^tm3Tl/Jchain⁺ involves: 129P2/OlaHsd	abnormal B cell physiology	J:56158
	abnormal immune cell physiology	J:49168
	decreased IgM level	J:49168, J:56158
	decreased plasma cell number	J:49168
	impaired complement classical pathway	J:49168
	increased IgA level	J:56158
	increased susceptibility to bacterial infection	J:56158
Jchain^tm3Tl/Jchain^tm3Tl involves: 129P2/OlaHsd	abnormal B cell physiology	J:56158
	abnormal immune cell physiology	J:49168
	decreased IgG level	J:49168
	decreased IgM level	J:49168, J:56158
	decreased plasma cell number	J:49168, J:56158
	impaired complement classical pathway	J:49168
	increased IgA level	J:49168, J:56158
	increased susceptibility to bacterial infection	J:56158

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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