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QTL Variant Detail
QTL variant: MijuC3HeB/FeJ
Name: modifier of IgJ upregulation; C3HeB/FeJ
MGI ID: MGI:3619554
QTL: Miju  Location: unknown  Genetic Position: Chr12, Syntenic
Strain of Specimen:  C3HeB/FeJ
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased serum IgA levels compared to C57BL/6J. (J:91062)
Inheritance:    Dominant
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Animals with this allele in conjunction with the IgjMat1 mutation exhibit a 40-fold increase in serum IgJ levels on a C57BL/6J background.

Mapping and Phenotype information for this QTL, its variants and associated markers


An ENU-induced mutation resulting in 40-fold increased serum IgA levels mapped to the Igj gene on mouse Chromosome 5. The mutation was created on the C3HeB/FeJ genetic background and is named IgjMat1. A modifying locus was mapped using 89 animals from a (C3HeB/FeJ-IgjMat1 x C57BL/6J)F2 intercross. 86 single nucleotide polymorphisms were used for linkage analysis. A locus named Miju (modifier of IgJ upregulation) was identified at 58 cM (107.64 Mb) on mouse Chromosome 12 near D12Mit20. Miju contributes to 71% of the phenotypic variance, and together with IgJMat1 account for 91% of the variation. Miju maps to a 0.35 Mb interval between SNPb 3-4-4 and D12Mit8 (58 cM). An attractive candidate gene mapping to this interval is Igh-Ia at 58.5 cM. Crip1 (57.9 cM) and Crip2 (58.7 cM) are also potential candidates. Animals carrying IgjMat1 and C3HeB/FeJ-derived alleles at Miju exhibit a 40-fold increase in serum IgA.

Original:  J:91062 Schneider B, et al., Synergistic interaction of two independent genetic loci causes extreme elevation of serum IgA in mice. Genes Immun. 2004 Jul;5(5):375-380
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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