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Hsf1 Gene Detail
Summary
  • Symbol
    Hsf1
  • Name
    heat shock factor 1
  • Synonyms
    heat shock transcription factor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96238
    NCBI Gene: 15499
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:76361562-76385355 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 35.95 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    487 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96238
 protein coding gene Chr15:76361562-76386113 (+)
129S1/SvImJ ENSMUSG00200051111
 protein coding gene Chr15:73475821-73499367 (+)
A/J ENSMUSG00195050526
 protein coding gene Chr15:73450494-73474050 (+)
AKR/J ENSMUSG00220048086
 protein coding gene Chr15:73461302-73484850 (+)
BALB/cJ ENSMUSG00180051616
 protein coding gene Chr15:73275633-73299189 (+)
C3H/HeJ ENSMUSG00175051906
 protein coding gene Chr15:73639056-73662611 (+)
C57BL/6NJ ENSMUSG00215048466
 protein coding gene Chr15:73367661-73391212 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019930
 protein coding gene Chr15:70428074-70454083 (+)
CAST/EiJ ENSTCUG00005044581
 protein coding gene Chr15:72981503-73005233 (+)
CBA/J ENSMUSG00210037398
 protein coding gene Chr15:73414266-73437820 (+)
DBA/2J ENSMUSG00185049179
 protein coding gene Chr15:73391259-73414811 (+)
FVB/NJ ENSMUSG00205044387
 protein coding gene Chr15:73143752-73167307 (+)
JF1/MsJ ENSUMUG00000049924
 protein coding gene Chr15:73043903-73068847 (+)
LP/J ENSMUSG00230052574
 protein coding gene Chr15:76756994-76780551 (+)
NOD/ShiLtJ ENSMUSG00190052100
 protein coding gene Chr15:73397547-73421057 (+)
NZO/HlLtJ ENSMUSG00225050472
 protein coding gene Chr15:77062708-77086215 (+)
PWK/PhJ ENSLUMG00010049414
 protein coding gene Chr15:73335708-73360701 (+)
SPRET/EiJ ENSMSPG00010044309
 protein coding gene Chr15:74940928-74966162 (+)
WSB/EiJ ENSIUOG00005037165
 protein coding gene Chr15:73463490-73487037 (+)



Homology
more
  • Human Ortholog
    HSF1, heat shock transcription factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSF1, heat shock transcription factor 1
  • Synonyms
    HSTF1
  • Links
    NCBI Gene ID: 3297
    UniProt: Q00613

  • Chr Location
    8q24.3; chr8:144291529-144314727 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HSF1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 5 alleles in 8 genetic backgrounds
    27 phenotypes from multigenic genotypes
    4 images
    141 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of this gene results in female infertility. Additional abnormalities observed in one line of targeted mice include placental defects, growth retardation, loss of the classical heat shock response, and impaired immune response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    185
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    117
  • cDNA Data
    60
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15499 NCBI Gene Model | MGI Sequence Detail 23794 C57BL/6J ±  kb
    transcript NM_001331152 RefSeq | MGI Sequence Detail 2434 ZRU/MplStud  
    polypeptide P38532 UniProt | EBI | MGI Sequence Detail 525 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      15 Sequences
    • Protein Ontology
      PR:000008790 heat shock factor protein 1
      (term hierarchy)
    • InterPro Domains
      IPR000232 Heat shock factor (HSF)-type, DNA-binding
      IPR010542 Vertebrate heat shock transcription factor, C-terminal domain
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    • GlyGen
      P38532 5 sites, 1 O-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 76
      Genomic 6
      cDNA 64
      Primer pair 5
      Other 1
      Antibodies 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10952, MGI:2145933
    References
    more
    • Summaries
      All 279
      Developmental Gene Expression 17
      Diseases 2
      Gene Ontology 22
      Phenotypes 141
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory