H19 MGI Mouse Gene Detail - MGI:95891 - H19, imprinted maternally expressed transcript

Symbol

H19
Name

H19, imprinted maternally expressed transcript

Feature Type

lncRNA gene
IDs

MGI:95891
NCBI Gene: 14955
Alliance

genome feature page
Transcription Start Sites

28 TSS
Regulated by

Rr28, Rr563, Rr564 ... (7 regulatory regions)

Sequence Map

Chr7:142129267-142131883 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 87.97 cM
Mapping Data

38 experiments

SNPs within 2kb

93 from dbSNP Build 142
Strain Annotations

31
PCR

3
RFLP

16

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95891	lncRNA gene	Chr7:142129262-142133957 (-)
129S1/SvImJ	ENSMUSG00200040298	protein coding gene	Chr7:128695602-128698266 (-)
129S1/SvImJ	ENSMUSG00200047761	lncRNA gene	Chr7:128695639-128698263 (-)
A/J	ENSMUSG00195041171	lncRNA gene	Chr7:133177692-133180316 (-)
A/J	ENSMUSG00195038323	protein coding gene	Chr7:133177655-133180319 (-)
AKR/J	ENSMUSG00220036808	lncRNA gene	Chr7:126659919-126662543 (-)
AKR/J	ENSMUSG00220025014	protein coding gene	Chr7:126659882-126662546 (-)
BALB/cJ	ENSMUSG00180035227	protein coding gene	Chr7:129869053-129871718 (-)
BALB/cJ	ENSMUSG00180041459	lncRNA gene	Chr7:129869090-129871715 (-)
C3H/HeJ	ENSMUSG00175046176	lncRNA gene	Chr7:130598623-130601248 (-)
C3H/HeJ	ENSMUSG00175030135	protein coding gene	Chr7:130598586-130601251 (-)
C57BL/6NJ	ENSMUSG00215041834	protein coding gene	Chr7:129864926-129867591 (-)
C57BL/6NJ	ENSMUSG00215047361	lncRNA gene	Chr7:129864963-129867588 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0006643	lincRNA gene	Chr7:144776697-144779312 (-)
CAST/EiJ	ENSTCUG00005051201	lncRNA gene	Chr7:133167187-133169817 (-)
CBA/J	ENSMUSG00210027079	protein coding gene	Chr7:130356506-130359171 (-)
CBA/J	ENSMUSG00210031358	lncRNA gene	Chr7:130356543-130359168 (-)
DBA/2J	ENSMUSG00185018690	lncRNA gene	Chr7:134635123-134637747 (-)
DBA/2J	ENSMUSG00185014652	protein coding gene	Chr7:134635086-134637750 (-)
FVB/NJ	ENSMUSG00205043622	protein coding gene	Chr7:130277211-130279875 (-)
FVB/NJ	ENSMUSG00205047719	lncRNA gene	Chr7:130277248-130279872 (-)
JF1/MsJ	ENSUMUG00000048883	lncRNA gene	Chr7:139710554-139713179 (-)
LP/J	ENSMUSG00230043207	lncRNA gene	Chr7:140798459-140801083 (-)
LP/J	ENSMUSG00230039726	protein coding gene	Chr7:140798422-140801086 (-)
NOD/ShiLtJ	ENSMUSG00190030398	lncRNA gene	Chr7:130464020-130466645 (-)
NOD/ShiLtJ	ENSMUSG00190020690	protein coding gene	Chr7:130463983-130466648 (-)
NZO/HlLtJ	ENSMUSG00225051704	protein coding gene	Chr7:139007346-139010010 (-)
NZO/HlLtJ	ENSMUSG00225053012	lncRNA gene	Chr7:139007383-139010007 (-)
PWK/PhJ	ENSLUMG00010048715	lncRNA gene	Chr7:128838949-128841574 (-)
SPRET/EiJ	ENSMSPG00010044793	lncRNA gene	Chr7:130304905-130307530 (-)
WSB/EiJ	ENSIUOG00005037871	lncRNA gene	Chr7:131227299-131229923 (-)

Human Ortholog

H19, H19 imprinted maternally expressed transcript

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

H19, H19 imprinted maternally expressed transcript
Synonyms

ASM, ASM1, BWS, D11S813E, GMRSP, LINC00008, MIR675HG, NCRNA00008, WT2
Links

HGNC:4713

NCBI Gene ID: 283120
Chr Location

11p15.5; chr11:1995165-2004552 (-) GRCh38

MGI Vertebrate Homology

H19 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: H19
Gene Tree

H19

Diseases

12 with human H19 associations

				Human Disease	Mouse Models
				Beckwith-Wiedemann syndrome IDs Beckwith-Wiedemann syndrome DOID:5572 ICD10CM:Q87.3 MESH:D001506 NCI:C34415 OMIM:130650 ORDO:116 UMLS_CUI:C0004903
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
				cerebral infarction IDs cerebral infarction DOID:3526 ICD10CM:I63 MESH:D002544 NCI:C50486 OMIM:601367 UMLS_CUI:C0007785
				coronary artery disease IDs coronary artery disease DOID:3393 DOID:10506 DOID:3363 DOID:3394 DOID:9420 EFO:0001645 ICD10CM:I20-I25 ICD10CM:I25 ICD10CM:I25.10 ICD9CM:410-414.99 ICD9CM:414.0 ICD9CM:414.9 MESH:D003324 MESH:D003327 MESH:D017202 NCI:C35505 NCI:C50625 OMIM:300464 OMIM:607339 OMIM:608316 OMIM:608318 OMIM:608320 OMIM:610947 OMIM:611139 OMIM:612030 OMIM:614293 UMLS_CUI:C0010054 UMLS_CUI:C0010068 UMLS_CUI:C0151744 UMLS_CUI:C0264694
				mature T-cell and NK-cell lymphoma IDs mature T-cell and NK-cell lymphoma DOID:0050743
				nephroblastoma IDs nephroblastoma DOID:2154 DOID:5177 DOID:5180 MESH:D009396 NCI:C27730 NCI:C3267 NCI:C6180 OMIM:194070 UMLS_CUI:C0027708 UMLS_CUI:C1332219 UMLS_CUI:C1333015
				ovary epithelial cancer IDs ovary epithelial cancer DOID:2152 NCI:C4381 UMLS_CUI:C0341823
				renal Wilms' tumor IDs renal Wilms' tumor DOID:5176 NCI:C6951 UMLS_CUI:C1335062
				severe pre-eclampsia IDs severe pre-eclampsia DOID:13129 DOID:13130 DOID:13131 DOID:13132 ICD9CM:642.50 UMLS_CUI:C0156669
				Silver-Russell syndrome IDs Silver-Russell syndrome DOID:14681 ICD10CM:Q87.19 MESH:D056730 NCI:C85068 OMIM:180860 UMLS_CUI:C0175693
				teratoma IDs teratoma DOID:3307 MESH:D013724 NCI:C3403 UMLS_CUI:C0039538
				urinary bladder cancer IDs urinary bladder cancer DOID:11054 DOID:5428 ICD10CM:C67 ICD9CM:188 ICD9CM:188.9 KEGG:05219 MESH:D001749 NCI:C2901 NCI:C9334 OMIM:109800 UMLS_CUI:C0005684 UMLS_CUI:C0005695

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

8 phenotypes from 7 alleles in 9 genetic backgrounds
21 phenotypes from multigenic genotypes
61 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Endonuclease-mediated

13
Targeted

11
Transgenic

5
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased body weight. Mice heterozygous for a maternally inherited knock-out allele exhibit increased placenta and body weight. Mice heterozygous for a different knock-out allele paternally inherited exhibit decreased fetal and postnatal body weight.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1364
Tissues

240
cDNA Data

37
Literature Summary

151

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

80
RefSeq

2
UniProt

2

Ensembl

ENSMUSG00000000031 (Evidence)
NCBI Gene

14955

			Length	Strain/Species	Flank
genomic	14955	NCBI Gene Model \| MGI Sequence Detail	2617	C57BL/6J	± kb
transcript	NR_130973	RefSeq \| MGI Sequence Detail	2288	ZRU/MplStud
polypeptide	Q61639	UniProt \| EBI \| MGI Sequence Detail	147	Not Applicable

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UniProt

2 Sequences

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All nucleic 155

Genomic 47

cDNA 44

Primer pair 42

Other 22

Microarray probesets 3

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MGD-MRK-10486, MGI:2142026

Summaries

All 389

Developmental Gene Expression 151

Diseases 1

Phenotypes 61
Earliest

J:20185 Crouse HV, The controlling element in sex chromosome behavior in Sciara. Genetics. 1960;45(10):1425-43
Latest

J:390374 Hilbold EA, et al., Loss of lncRNA H19 impairs neonatal cardiac regeneration. Am J Physiol Cell Physiol. 2026 Aug 1;331(2):C358-C372

H19 expression regulated by:

Feature	Feature Type	Location	Reference
Rr28, regulatory region 28	enhancer	Chr7:142122776-142124725	J:30955
Rr563, regulatory region 563	enhancer	Chr7:142140547-142140846	J:74785
Rr564, regulatory region 564	enhancer	Chr7:142140547-142142403	J:74785
Rr562, regulatory region 562	enhancer	Chr7:142142210-142142403	J:74785
Rr128, regulatory region 128	silencer	Chr7, Syntenic	J:63213
Rr129, regulatory region 129	unclassified other genome feature	Chr7, Syntenic	J:106218
Rr695614, regulatory region 695614	enhancer	Chr7, Syntenic	J:94077

TSS for H19:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr75845	Chr7:142131876-142131891 (-)	-1 bp
Tssr75844	Chr7:142131830-142131858 (-)	39 bp
Tssr75843	Chr7:142131823-142131828 (-)	57 bp
Tssr75842	Chr7:142131816-142131822 (-)	64 bp
Tssr75841	Chr7:142131779-142131805 (-)	91 bp
Tssr75840	Chr7:142131777-142131778 (-)	105 bp
Tssr75839	Chr7:142131735-142131749 (-)	141 bp
Tssr75838	Chr7:142131722-142131727 (-)	158 bp
Tssr75837	Chr7:142131645-142131657 (-)	232 bp
Tssr75836	Chr7:142131625-142131634 (-)	253 bp
Tssr75835	Chr7:142131603-142131612 (-)	275 bp
Tssr75834	Chr7:142131567-142131580 (-)	309 bp
Tssr75828	Chr7:142130624-142130625 (-)	1,258 bp
Tssr75827	Chr7:142130480-142130493 (-)	1,396 bp
Tssr75826	Chr7:142130455-142130473 (-)	1,419 bp
Tssr75825	Chr7:142130405-142130425 (-)	1,468 bp
Tssr75824	Chr7:142130284-142130301 (-)	1,590 bp
Tssr75823	Chr7:142130229-142130268 (-)	1,634 bp
Tssr75822	Chr7:142130169-142130225 (-)	1,686 bp
Tssr75821	Chr7:142130053-142130064 (-)	1,824 bp
Tssr75820	Chr7:142130003-142130051 (-)	1,856 bp
Tssr75819	Chr7:142129958-142130000 (-)	1,904 bp
Tssr75818	Chr7:142129759-142129830 (-)	2,088 bp
Tssr75817	Chr7:142129660-142129754 (-)	2,176 bp
Tssr75816	Chr7:142129575-142129591 (-)	2,300 bp
Tssr75815	Chr7:142129516-142129530 (-)	2,360 bp
Tssr75814	Chr7:142129353-142129366 (-)	2,523 bp
Tssr75813	Chr7:142129291-142129314 (-)	2,580 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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