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Flt4 Gene Detail
Summary
  • Symbol
    Flt4
  • Name
    FMS-like tyrosine kinase 4
  • Synonyms
    Flt-4, VEGFR-3, VEGFR3
  • Feature Type
    protein coding gene
  • IDs
    MGI:95561
    NCBI Gene: 14257
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:49500506-49543566 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 29.69 cM, cytoband A5-B1
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1071 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95561
 protein coding gene Chr11:49500090-49543566 (+)
129S1/SvImJ ENSMUSG00200038327
 protein coding gene Chr11:46478268-46521751 (+)
A/J ENSMUSG00195032366
 protein coding gene Chr11:46429036-46472515 (+)
AKR/J ENSMUSG00220033236
 protein coding gene Chr11:46615827-46659300 (+)
BALB/cJ ENSMUSG00180033745
 protein coding gene Chr11:46490504-46533998 (+)
C3H/HeJ ENSMUSG00175031291
 protein coding gene Chr11:46460693-46504167 (+)
C57BL/6NJ ENSMUSG00215034398
 protein coding gene Chr11:46387507-46430992 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016275
 protein coding gene Chr11:44479385-44535973 (+)
CAST/EiJ ENSTCUG00005040837
 protein coding gene Chr11:46024150-46052583 (+)
CBA/J ENSMUSG00210027762
 protein coding gene Chr11:46316658-46360130 (+)
DBA/2J ENSMUSG00185026913
 protein coding gene Chr11:46570846-46614327 (+)
FVB/NJ ENSMUSG00205020818
 protein coding gene Chr11:46373696-46401915 (+)
JF1/MsJ ENSUMUG00000032772
 protein coding gene Chr11:46825622-46869150 (+)
LP/J ENSMUSG00230028161
 protein coding gene Chr11:47710000-47753481 (+)
NOD/ShiLtJ ENSMUSG00190031237
 protein coding gene Chr11:46575291-46618764 (+)
NZO/HlLtJ ENSMUSG00225035173
 protein coding gene Chr11:49694355-49737823 (+)
PWK/PhJ ENSLUMG00010028967
 protein coding gene Chr11:46338503-46381968 (+)
SPRET/EiJ ENSMSPG00010016678
 protein coding gene Chr11:47005679-47047619 (+)
WSB/EiJ ENSIUOG00005039034
 protein coding gene Chr11:46374190-46417681 (+)



Homology
more
  • Human Ortholog
    FLT4, fms related receptor tyrosine kinase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FLT4, fms related receptor tyrosine kinase 4
  • Synonyms
    CHTD7, FLT-4, FLT41, LMPH1A, LMPHM1, PCL, VEGFR-3, VEGFR3
  • Links
    NCBI Gene ID: 2324
    UniProt: P35916

  • Chr Location
    5q35.3; chr5:180601506-180650298 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Flt4 mouse models; 1 with human FLT4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 6 alleles in 6 genetic backgrounds
    13 phenotypes from multigenic genotypes
    5 images
    126 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a targeted null mutation show growth retardation, vascular abnormalities, severe anemia and die from cardiovascular failure at embryonic day 9.5. Heterozygotes for another mutation show abdominal chylous ascites, abnormal lymphaticvessels, and lymphedema.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    98
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    968
  • Tissues
    168
  • cDNA Data
    22
  • Literature Summary
    202
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14257 NCBI Gene Model | MGI Sequence Detail 43061 C57BL/6J ±  kb
    transcript NM_008029 RefSeq | MGI Sequence Detail 5853 ZRU/MplStud  
    polypeptide P35917 UniProt | EBI | MGI Sequence Detail 1363 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      Genomic 1
      cDNA 25
      Primer pair 10
      Other 3
      Antibodies 14

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1984, MGD-MRK-9835, MGD-MRK-9839, MGI:2144119, MGI:88402
    References
    more
    • Summaries
      All 377
      Developmental Gene Expression 202
      Diseases 1
      Gene Ontology 23
      Phenotypes 126
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:391818 Lara Ochoa S, et al., PROX1 loss in adult mouse Schlemm's canal causes permanent ocular hypertension. JCI Insight. 2026 Jun 22;11(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory