Sequence Detail

ID/Version

P35917 (UniProt | EBI)

Last sequence update: 1994-06-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Vascular endothelial growth factor receptor 3; Short=VEGFR-3; EC=2.7.10.1;AltName: Full=Fms-like tyrosine kinase 4; Short=FLT-4;AltName: Full=Tyrosine-protein kinase receptor FLT4;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1363 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Flt4	FMS-like tyrosine kinase 4	73	139	3	21

Sequence references in MGI

J:919 Galland F, et al., Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene. Genomics. 1992 Jun;13(2):475-8
J:13199 Finnerty H, et al., Molecular cloning of murine FLT and FLT4. Oncogene. 1993 Aug;8(8):2293-8
J:50761 Dumont DJ, et al., Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. Science. 1998 Oct 30;282(5390):946-9
J:138577 Tammela T, et al., Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature. 2008 Jul 31;454(7204):656-60
J:161965 Wang Y, et al., Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature. 2010 May 27;465(7297):483-6
J:175965 Tammela T, et al., VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nat Cell Biol. 2011 Sep 11;
J:177405 Zhang L, et al., VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis. Cell Res. 2010 Dec;20(12):1319-31
J:262023 Morooka N, et al., Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling. Circ Res. 2017 Apr 14;120(8):1276-1288