Fgf1 MGI Mouse Gene Detail - MGI:95515 - fibroblast growth factor 1

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Fgf1 Gene Detail

Symbol

Fgf1
Name

fibroblast growth factor 1
Synonyms

Fgf-1, Fgfa, fibroblast growth factor 1 (acidic)

Feature Type

protein coding gene
IDs

MGI:95515
NCBI Gene: 14164
Alliance

genome feature page
Transcription Start Sites

13 TSS
Candidate for QTL

2 QTL

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Sequence Map

Chr18:38971726-39062525 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 20.74 cM
Mapping Data

25 experiments

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SNPs within 2kb

2835 from dbSNP Build 142
Strain Annotations

19
RFLP

6

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_95515	protein coding gene	Chr18:38971725-39062532 (-)
129S1/SvImJ	ENSMUSG00200041527	protein coding gene	Chr18:35970182-36060879 (-)
A/J	ENSMUSG00195033283	protein coding gene	Chr18:36122671-36213369 (-)
AKR/J	ENSMUSG00220016673	protein coding gene	Chr18:36090658-36181376 (-)
BALB/cJ	ENSMUSG00180018771	protein coding gene	Chr18:36572249-36662970 (-)
C3H/HeJ	ENSMUSG00175038210	protein coding gene	Chr18:36089544-36180328 (-)
C57BL/6NJ	ENSMUSG00215023689	protein coding gene	Chr18:35842608-35933427 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022215	protein coding gene	Chr18:36037840-36127615 (-)
CAST/EiJ	ENSTCUG00005020771	protein coding gene	Chr18:35708192-35797947 (-)
CBA/J	ENSMUSG00210020447	protein coding gene	Chr18:36114233-36204941 (-)
DBA/2J	ENSMUSG00185018891	protein coding gene	Chr18:36048780-36139477 (-)
FVB/NJ	ENSMUSG00205019905	protein coding gene	Chr18:35752029-35848344 (-)
JF1/MsJ	ENSUMUG00000023297	protein coding gene	Chr18:36185389-36275436 (-)
LP/J	ENSMUSG00230046984	protein coding gene	Chr18:38165135-38255828 (-)
NOD/ShiLtJ	ENSMUSG00190017603	protein coding gene	Chr18:35837797-35928569 (-)
NZO/HlLtJ	ENSMUSG00225046554	protein coding gene	Chr18:38070976-38161814 (-)
PWK/PhJ	ENSLUMG00010011402	protein coding gene	Chr18:36333057-36423411 (-)
SPRET/EiJ	ENSMSPG00010021106	protein coding gene	Chr18:36366617-36453335 (-)
WSB/EiJ	ENSIUOG00005007161	protein coding gene	Chr18:35830496-35921441 (-)

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Human Ortholog

FGF1, fibroblast growth factor 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FGF1, fibroblast growth factor 1
Synonyms

AFGF, ECGF, ECGFA, ECGFB, ECGF-beta, FGF-1, FGFA, FGF-alpha, GLIO703, HBGF-1, HBGF1
Links

HGNC:3665

NCBI Gene ID: 2246

UniProt: P05230
Chr Location

5q31.3; chr5:142592166-142698070 (-) GRCh38

MGI Vertebrate Homology

Fgf1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FGF1
Gene Tree

Fgf1

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Diseases

5 with human FGF1 associations

				Human Disease	Mouse Models
				brain ischemia IDs brain ischemia DOID:2316 MESH:D002545 UMLS_CUI:C0007786
				cleft lip IDs cleft lip DOID:9296 DOID:9333 EFO:0003959 ICD10CM:Q36 ICD9CM_2006:749.11 ICD9CM:749.1 ICD9CM:749.10 ICD9CM:749.11 MESH:D002971 NCI:C87175 UMLS_CUI:C0008924 UMLS_CUI:C0158651
				myocardial infarction IDs myocardial infarction DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051
				schizophrenia IDs schizophrenia DOID:5419 DOID:14734 ICD10CM:F20 ICD9CM:295 ICD9CM:295.8 ICD9CM:295.80 ICD9CM:295.9 ICD9CM:295.90 MESH:D012559 NCI:C3362 OMIM:181500 UMLS_CUI:C0036341
				urinary bladder cancer IDs urinary bladder cancer DOID:11054 DOID:5428 ICD10CM:C67 ICD9CM:188 ICD9CM:188.9 KEGG:05219 MESH:D001749 NCI:C2901 NCI:C9334 OMIM:109800 UMLS_CUI:C0005684 UMLS_CUI:C0005695

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
13 phenotype references

All Mutations and Alleles

52
Endonuclease-mediated

7
Gene trapped

41
Targeted

4
Find Mice (IMSR)

44 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele are viable, breed and develop normally, and exhibit normal brain structure and normal rates of wound healing.

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All GO Annotations

106
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1141
Tissues

317
cDNA Data

44
Literature Summary

79

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fgf1

ZFIN fgf1a, fgf1b

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All Sequences

100
RefSeq

36
UniProt

8
CCDS

CCDS29204.1

Ensembl

ENSMUSG00000036585 (Evidence)
NCBI Gene

14164

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000036585	Ensembl Gene Model \| MGI Sequence Detail	90800	C57BL/6J	± kb
	transcript	ENSMUST00000040647	Ensembl \| MGI Sequence Detail	3981	Not Applicable
	polypeptide	ENSMUSP00000045710	Ensembl \| MGI Sequence Detail	155	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000007479 fibroblast growth factor 1

(term hierarchy)
InterPro Domains

IPR008996 Cytokine IL1/FGF

IPR002209 Fibroblast growth factor family

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All nucleic 87

Genomic 12

cDNA 51

Primer pair 14

Other 10

Antibodies 2

Microarray probesets 4

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MGD-MRK-9760, MGD-MRK-9766, MGD-MRK-9773

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Summaries

All 212

Developmental Gene Expression 79

Gene Ontology 17

Phenotypes 13
Earliest

J:13138 Roberts E, A new mutation in the house mouse (Mus musculus). Science. 1931;74:569
Latest

J:381825 Ikeda S, et al., Fgf10 Gene Dosage from a Single Allele Is Insufficient for Forming Multilayered Epithelial Cells in the Murine Lacrimal Gland. Int J Mol Sci. 2026 Feb 24;27(5)

TSS for Fgf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr153067	Chr18:39062515-39062533 (-)	1 bp
Tssr153066	Chr18:39062454-39062463 (-)	66 bp
Tssr153065	Chr18:39062431-39062449 (-)	85 bp
Tssr153064	Chr18:39062226-39062252 (-)	286 bp
Tssr153063	Chr18:39062201-39062221 (-)	314 bp
Tssr153062	Chr18:39062186-39062198 (-)	333 bp
Tssr153061	Chr18:39051695-39051763 (-)	10,796 bp
Tssr153060	Chr18:39014565-39014572 (-)	47,956 bp
Tssr153059	Chr18:39014480-39014508 (-)	48,031 bp
Tssr153058	Chr18:39000134-39000145 (-)	62,385 bp
Tssr153057	Chr18:39000111-39000127 (-)	62,406 bp
Tssr153056	Chr18:39000060-39000069 (-)	62,460 bp
Tssr153055	Chr18:38999755-38999801 (-)	62,747 bp

Fgf1 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Bwq4	Chr18, 18.83 cM		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 18, Fgf1 (19 cM) shows differential expression between the restricted and unrestricted diets on the A/A background. Diabesity QTL Nidd2 (16 cM) maps near candidate gene Fgf1. Cd14 (31 cM) shows differential expression between A/a and A/A animals on the unrestricted diet. Diabesity QTL Bwq4 (28 cM) maps near candidate gene Cd14.
Nidd2	Chr18, 18.04 cM		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 18, Fgf1 (19 cM) shows differential expression between the restricted and unrestricted diets on the A/A background. Diabesity QTL Nidd2 (16 cM) maps near candidate gene Fgf1. Cd14 (31 cM) shows differential expression between A/a and A/A animals on the unrestricted diet. Diabesity QTL Bwq4 (28 cM) maps near candidate gene Cd14.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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