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Crk Gene Detail
Summary
  • Symbol
    Crk
  • Name
    Crk proto-oncogene, adaptor protein
  • Synonyms
    Crk-I, Crk-II, Crk-III, Crko, proto-oncogene c-crk
  • Feature Type
    protein coding gene
  • IDs
    MGI:88508
    NCBI Gene: 12928
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:75570085-75597734 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 45.92 cM, cytoband A-D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    653 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88508
 protein coding gene Chr11:75570020-75599254 (+)
129S1/SvImJ ENSMUSG00200048834
 protein coding gene Chr11:72687910-72715493 (+)
A/J ENSMUSG00195040866
 protein coding gene Chr11:72566324-72593894 (+)
AKR/J ENSMUSG00220043231
 protein coding gene Chr11:72781531-72809115 (+)
BALB/cJ ENSMUSG00180032316
 protein coding gene Chr11:72754760-72782329 (+)
C3H/HeJ ENSMUSG00175038383
 protein coding gene Chr11:72724660-72752244 (+)
C57BL/6NJ ENSMUSG00215037073
 protein coding gene Chr11:72346480-72374131 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016747
 protein coding gene Chr11:70610445-70638640 (+)
CAST/EiJ ENSTCUG00005045241
 protein coding gene Chr11:72248457-72276328 (+)
CBA/J ENSMUSG00210039429
 protein coding gene Chr11:72543140-72570722 (+)
DBA/2J ENSMUSG00185034384
 protein coding gene Chr11:72813129-72840713 (+)
FVB/NJ ENSMUSG00205045775
 protein coding gene Chr11:72649678-72677333 (+)
JF1/MsJ ENSUMUG00000052032
 protein coding gene Chr11:73196373-73224178 (+)
LP/J ENSMUSG00230044126
 protein coding gene Chr11:73843753-73871335 (+)
NOD/ShiLtJ ENSMUSG00190045519
 protein coding gene Chr11:72859553-72887137 (+)
NZO/HlLtJ ENSMUSG00225038488
 protein coding gene Chr11:76017387-76044935 (+)
PWK/PhJ ENSLUMG00010020429
 protein coding gene Chr11:72714595-72742421 (+)
SPRET/EiJ ENSMSPG00010042918
 protein coding gene Chr11:73114073-73141405 (+)
WSB/EiJ ENSIUOG00005029814
 protein coding gene Chr11:72713042-72741057 (+)



Homology
more
  • Human Ortholog
    CRK, CRK proto-oncogene, adaptor protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRK, CRK proto-oncogene, adaptor protein
  • Synonyms
    CRKII, p38
  • Links
    NCBI Gene ID: 1398
    UniProt: P46108

  • Chr Location
    17p13.3; chr17:1420689-1463162 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an isoform specific knockout do not exhibit any obvious abnormalities. Mice homozygous of a null allele of both isoforms exhibit fetal and perinatal lethality associated with abnormal cardiovascular morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    151
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    748
  • Tissues
    90
  • cDNA Data
    27
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017776 Ensembl Gene Model | MGI Sequence Detail 27650 C57BL/6J ±  kb
    transcript ENSMUST00000017920 Ensembl | MGI Sequence Detail 3642 Not Applicable  
    polypeptide ENSMUSP00000017920 Ensembl | MGI Sequence Detail 304 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      Genomic 3
      cDNA 31
      Primer pair 3
      Other 2
      Antibodies 4

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-2151
    References
    more
    • Summaries
      All 126
      Developmental Gene Expression 20
      Gene Ontology 31
      Phenotypes 29
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:341382 Wu B, et al., Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development. J Am Heart Assoc. 2023 Sep 19;12(18):e029683
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory