Gene Ontology Classifications

Symbol
Name
ID

Crk
Crk proto-oncogene, adaptor protein
MGI:88508

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Automated description from the Alliance of Genome Resources (Release 8.3.0)

Enables protein phosphorylated amino acid binding activity; signaling receptor complex adaptor activity; and ubiquitin protein ligase binding activity. Involved in several processes, including enzyme-linked receptor protein signaling pathway; positive regulation of Rac protein signal transduction; and postsynaptic specialization assembly. Acts upstream of or within several processes, including activation of GTPase activity; nervous system development; and reelin-mediated signaling pathway. Located in actin cytoskeleton and membrane. Is active in neuromuscular junction. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; immune system; and musculature. Orthologous to human CRK (CRK proto-oncogene, adaptor protein).

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Aspect

Category

Evidence

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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