GO Annotations Graph

• Symbol: Crk
• Name: v-crk avian sarcoma virus CT10 oncogene homolog
• ID: MGI:88508

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008092	cytoskeletal protein binding	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0046875	ephrin receptor binding	ISO	J:164563
Molecular Function	GO:0046875	ephrin receptor binding	IPI	J:175107
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	ISO	J:155856
Molecular Function	GO:0019900	kinase binding	ISO	J:164563
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0001784	phosphotyrosine residue binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:200351
Molecular Function	GO:0005515	protein binding	IPI	J:149152
Molecular Function	GO:0005515	protein binding	IPI	J:88736
Molecular Function	GO:0005515	protein binding	IPI	J:85284
Molecular Function	GO:0005515	protein binding	IPI	J:79164
Molecular Function	GO:0005515	protein binding	IPI	J:107908
Molecular Function	GO:0005515	protein binding	IPI	J:90089
Molecular Function	GO:0005515	protein binding	IPI	J:86622
Molecular Function	GO:0005515	protein binding	IPI	J:85284
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0045309	protein phosphorylated amino acid binding	ISO	J:164563
Molecular Function	GO:0045309	protein phosphorylated amino acid binding	IDA	J:85284
Molecular Function	GO:0043621	protein self-association	ISO	J:164563
Molecular Function	GO:1990782	protein tyrosine kinase binding	ISO	J:155856
Molecular Function	GO:1990782	protein tyrosine kinase binding	ISO	J:164563
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	ISO	J:155856
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:155856
Molecular Function	GO:0042169	SH2 domain binding	ISO	J:164563
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:164563
Molecular Function	GO:0035591	signaling adaptor activity	ISO	J:164563
Molecular Function	GO:0030159	signaling receptor complex adaptor activity	IPI	J:46223
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IPI	J:46223
Cellular Component	GO:0015629	actin cytoskeleton	IDA	J:75087
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IMP	J:188792
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0031594	neuromuscular junction	IMP	J:165470
Cellular Component	GO:0031594	neuromuscular junction	IDA	J:165470
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Biological Process	GO:0030036	actin cytoskeleton organization	ISO	J:164563
Biological Process	GO:0090630	activation of GTPase activity	IGI	J:220382
Biological Process	GO:0090630	activation of GTPase activity	IGI	J:220382
Biological Process	GO:0090630	activation of GTPase activity	IGI	J:220382
Biological Process	GO:0060326	cell chemotaxis	IGI	J:220382
Biological Process	GO:0008283	cell population proliferation	IGI	J:97143
Biological Process	GO:0008283	cell population proliferation	IGI	J:97143
Biological Process	GO:1990859	cellular response to endothelin	ISO	J:155856
Biological Process	GO:1990314	cellular response to insulin-like growth factor stimulus	ISO	J:155856
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	ISO	J:155856
Biological Process	GO:0071732	cellular response to nitric oxide	ISO	J:155856
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	ISO	J:155856
Biological Process	GO:0098749	cerebellar neuron development	IGI	J:143049
Biological Process	GO:0021987	cerebral cortex development	IGI	J:143049
Biological Process	GO:0016358	dendrite development	IGI	J:143049
Biological Process	GO:0048013	ephrin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0030010	establishment of cell polarity	IGI	J:220382
Biological Process	GO:0035685	helper T cell diapedesis	IGI	J:220382
Biological Process	GO:0021766	hippocampus development	IGI	J:143049
Biological Process	GO:0006629	lipid metabolic process	IGI	J:260356
Biological Process	GO:2000146	negative regulation of cell motility	ISO	J:164563
Biological Process	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	ISO	J:155856
Biological Process	GO:0061045	negative regulation of wound healing	ISO	J:164563
Biological Process	GO:0001764	neuron migration	IGI	J:143049
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	ISO	J:155856
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	ISO	J:155856
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:0098698	postsynaptic specialization assembly	IMP	J:165470
Biological Process	GO:0098698	postsynaptic specialization assembly	IDA	J:165470
Biological Process	GO:0072657	protein localization to membrane	ISO	J:155856
Biological Process	GO:0038026	reelin-mediated signaling pathway	IGI	J:139781
Biological Process	GO:0038026	reelin-mediated signaling pathway	IGI	J:143049
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	ISO	J:164563
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	IGI	J:166211
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	IGI	J:166211
Biological Process	GO:0033628	regulation of cell adhesion mediated by integrin	IGI	J:220382
Biological Process	GO:0008360	regulation of cell shape	ISO	J:164563
Biological Process	GO:0050773	regulation of dendrite development	IGI	J:139781
Biological Process	GO:0043087	regulation of GTPase activity	ISO	J:164563
Biological Process	GO:1902531	regulation of intracellular signal transduction	ISO	J:164563
Biological Process	GO:0002685	regulation of leukocyte migration	IGI	J:220382
Biological Process	GO:0043393	regulation of protein binding	ISO	J:164563
Biological Process	GO:0035020	regulation of Rac protein signal transduction	ISO	J:155856
Biological Process	GO:0009966	regulation of signal transduction	ISO	J:164563
Biological Process	GO:2000404	regulation of T cell migration	IGI	J:220382
Biological Process	GO:0061847	response to cholecystokinin	ISO	J:155856
Biological Process	GO:0035728	response to hepatocyte growth factor	ISO	J:155856
Biological Process	GO:0042542	response to hydrogen peroxide	ISO	J:155856
Biological Process	GO:1901652	response to peptide	ISO	J:155856