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Crh Gene Detail
Summary
  • Symbol
    Crh
  • Name
    corticotropin releasing hormone
  • Synonyms
    corticotropin releasing factor, corticotropin-releasing factor, CRF, LOC383938
  • Feature Type
    protein coding gene
  • IDs
    MGI:88496
    NCBI Gene: 12918
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
  • Regulated by
    Rr609 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr3:19747565-19749560 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 5.75 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    144 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88496
 protein coding gene Chr3:19747565-19749560 (-)
129S1/SvImJ ENSMUSG00200018214
 protein coding gene Chr3:16525529-16527524 (-)
A/J ENSMUSG00195015474
 protein coding gene Chr3:16577421-16579416 (-)
AKR/J ENSMUSG00220008962
 protein coding gene Chr3:16538512-16540507 (-)
BALB/cJ ENSMUSG00180000945
 protein coding gene Chr3:16599879-16601874 (-)
C3H/HeJ ENSMUSG00175003107
 protein coding gene Chr3:16597432-16599427 (-)
C57BL/6NJ ENSMUSG00215001206
 protein coding gene Chr3:16808032-16810027 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024875
 protein coding gene Chr3:14898042-14900041 (-)
CAST/EiJ ENSTCUG00005023714
 protein coding gene Chr3:16534328-16536323 (-)
CBA/J ENSMUSG00210001537
 protein coding gene Chr3:16572713-16574708 (-)
DBA/2J ENSMUSG00185000634
 protein coding gene Chr3:16791841-16793836 (-)
FVB/NJ ENSMUSG00205002346
 protein coding gene Chr3:16094732-16096727 (-)
JF1/MsJ ENSUMUG00000015938
 protein coding gene Chr3:16377320-16379315 (-)
LP/J ENSMUSG00230004013
 protein coding gene Chr3:18697229-18699224 (-)
NOD/ShiLtJ ENSMUSG00190001854
 protein coding gene Chr3:16953509-16955504 (-)
NZO/HlLtJ ENSMUSG00225006985
 protein coding gene Chr3:21343258-21345253 (-)
PWK/PhJ ENSLUMG00010003128
 protein coding gene Chr3:16407209-16409204 (-)
SPRET/EiJ ENSMSPG00010001766
 protein coding gene Chr3:16504412-16506409 (-)
WSB/EiJ ENSIUOG00005001258
 protein coding gene Chr3:16823411-16825406 (-)



Homology
more
  • Human Ortholog
    CRH, corticotropin releasing hormone
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRH, corticotropin releasing hormone
  • Synonyms
    CRF, CRH1
  • Links
    NCBI Gene ID: 1392
    UniProt: P06850

  • Chr Location
    8q13.1; chr8:66176376-66178464 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CRH associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 5 alleles in 6 genetic backgrounds
    3 phenotypes from multigenic genotypes
    335 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have abnormal adrenal gland morphology, decreased corticosterone levels and abnormal corticosteroid responses to stress. Homozygous litters born from homozygous females display neonatal lethality, impaired lung maturation and delayedcornified and granular layer development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    127
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    871
  • Tissues
    79
  • cDNA Data
    8
  • Literature Summary
    49
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12918 NCBI Gene Model | MGI Sequence Detail 1996 C57BL/6J ±  kb
    transcript NM_205769 RefSeq | MGI Sequence Detail 1338 C57BL/6  
    polypeptide Q8CIT0 UniProt | EBI | MGI Sequence Detail 187 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 2
      cDNA 8
      Primer pair 3
      Other 6
      Antibodies 4

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-2138, MGI:2686193
    References
    more
    • Summaries
      All 469
      Developmental Gene Expression 49
      Diseases 1
      Gene Ontology 17
      Phenotypes 335
    • Earliest
      J:19717 Vale W, et al., Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science. 1981 Sep 18;213(4514):1394-7
    • Latest
      J:389402 Hines RC, et al., Ozanimod and other sphingosine-1-phosphate receptor 1 modulators normalize neuropathic injury-enhanced inhibition of central lateral amygdala neurons expressing corticotropin-releasing hormone. Neuropharmacology. 2026 Apr 9;294:110967
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory