About   Help   FAQ
Asl Gene Detail
Summary
  • Symbol
    Asl
  • Name
    argininosuccinate lyase
  • Synonyms
    2510006M18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:88084
    NCBI Gene: 109900
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:130040099-130053222 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 68.37 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    428 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88084
 protein coding gene Chr5:130040099-130058088 (-)
129S1/SvImJ ENSMUSG00200041768
 protein coding gene Chr5:123785649-123799417 (-)
A/J ENSMUSG00195049173
 protein coding gene Chr5:123320099-123333871 (-)
AKR/J ENSMUSG00220049394
 protein coding gene Chr5:122796320-122810085 (-)
BALB/cJ ENSMUSG00180033796
 protein coding gene Chr5:123427453-123441221 (-)
C3H/HeJ ENSMUSG00175033483
 protein coding gene Chr5:125395933-125409695 (-)
C57BL/6NJ ENSMUSG00215048361
 protein coding gene Chr5:123458049-123471826 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027794
 protein coding gene Chr5:122846199-122864130 (-)
CAST/EiJ ENSTCUG00005009344
 protein coding gene Chr5:122693171-122707009 (-)
CBA/J ENSMUSG00210007154
 protein coding gene Chr5:124146606-124160370 (-)
DBA/2J ENSMUSG00185007094
 protein coding gene Chr5:127198564-127212326 (-)
FVB/NJ ENSMUSG00205047165
 protein coding gene Chr5:123079780-123093546 (-)
JF1/MsJ ENSUMUG00000042795
 protein coding gene Chr5:130088448-130102263 (-)
LP/J ENSMUSG00230045383
 protein coding gene Chr5:131301548-131315312 (-)
NOD/ShiLtJ ENSMUSG00190039498
 protein coding gene Chr5:123101503-123115270 (-)
NZO/HlLtJ ENSMUSG00225013486
 protein coding gene Chr5:138996986-139010746 (-)
PWK/PhJ ENSLUMG00010017860
 protein coding gene Chr5:121971790-121985560 (-)
SPRET/EiJ ENSMSPG00010029392
 protein coding gene Chr5:125396166-125410215 (-)
WSB/EiJ ENSIUOG00005029545
 protein coding gene Chr5:125780517-125794285 (-)



Homology
more
  • Human Ortholog
    ASL, argininosuccinate lyase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ASL, argininosuccinate lyase
  • Synonyms
    ASAL, ASLD
  • Links
    NCBI Gene ID: 435
    UniProt: P04424

  • Chr Location
    7q11.21; chr7:66075800-66094697 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Asl mouse models; 2 with human ASL associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 3 alleles in 1 genetic background
    2 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene fed well initially but then stopped feeding and became inactive before dying within 48 hours of birth. Arginine metabolism is disrupted leading to abnormal circulating amino acid levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    704
  • Tissues
    99
  • cDNA Data
    110
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 109900 NCBI Gene Model | MGI Sequence Detail 13124 C57BL/6J ±  kb
    transcript NM_133768 RefSeq | MGI Sequence Detail 1824 ZRU/MplStud  
    polypeptide Q91YI0 UniProt | EBI | MGI Sequence Detail 464 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 114
      cDNA 112
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1420, MGI:1924052
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 4
      Diseases 2
      Gene Ontology 12
      Phenotypes 28
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:372685 Kassir MF, et al., Alzheimer's Disease-Associated Amyloid-beta Precursor Protein Prevents Aging Stress-Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity. Cancer Res. 2025 Oct 1;85(19):3791-3811
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory